ID   S5UUD7_STRC3            Unreviewed;       406 AA.
AC   S5UUD7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   ORFNames=B446_13015 {ECO:0000313|EMBL:AGS69421.1};
OS   Streptomyces collinus (strain DSM 40733 / Tue 365).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1214242 {ECO:0000313|EMBL:AGS69421.1, ECO:0000313|Proteomes:UP000015423};
RN   [1] {ECO:0000313|Proteomes:UP000015423}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RA   Ruckert C., Szczepanowski R., Goesmann A., Pross E.K., Musiol E.M.,
RA   Blin K., Wohlleben W., Puhler A., Weber T., Kalinowski J.;
RT   "The complete genome sequence of Streptomyces collinus Tu 365.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AGS69421.1, ECO:0000313|Proteomes:UP000015423}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RX   PubMed=24140291; DOI=10.1016/j.jbiotec.2013.10.004;
RA   Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Iftime D.,
RA   Musiol E.M., Blin K., Wohlleben W., Puhler A., Kalinowski J., Weber T.;
RT   "Complete genome sequence of the kirromycin producer Streptomyces collinus
RT   Tu 365 consisting of a linear chromosome and two linear plasmids.";
RL   J. Biotechnol. 168:739-740(2013).
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DR   EMBL; CP006259; AGS69421.1; -; Genomic_DNA.
DR   RefSeq; WP_020939895.1; NC_021985.1.
DR   AlphaFoldDB; S5UUD7; -.
DR   STRING; 1214242.B446_13015; -.
DR   KEGG; sci:B446_13015; -.
DR   PATRIC; fig|1214242.5.peg.2667; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_0_11; -.
DR   Proteomes; UP000015423; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015423};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..406
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004533067"
FT   DOMAIN          63..371
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          258..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  43132 MW;  7A6EEF94EFE9E01D CRC64;
     MTPLSRVLLA ATALLTPLTT AHPARPAPPA RLASGCVSSV PYTAGQGGYA TYRIPATVVT
     RRGTVLAFAE GRHDGAGDSG DIDVLLRRST DGGCTWGPQT VVAAGEGDTR GNPAPVVDPR
     TGAIVLLTSY NGGSVTEAQI MRGEAAPDRG RRVFVQRSMD DGRGFTRPRD ITAEVKPAHW
     RWYATGPGHA LALTRGPHAG RLLIPADHST APPAGSSDTG QEPRYYGAHA LCSDDGGHTW
     HLGFTDTTHD GRVNANETTA TQLDDGRVYF TSRDQNGTSP GNRVDTYSSD GGATLDRPWR
     PQPALDGVPV VEASVLQLDG PGAPLLFSAP STPTARRAMT LWRSPDAGRT FAELLTLSPR
     PAGYSDLAQL DRHRVGILYE TGEKGPYERI EFARVRLDES VAMPRG
//