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Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus lutetiensis 033
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:KE3_0900Imported
OrganismiStreptococcus lutetiensis 033Imported
Taxonomic identifieri1076934 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000015268 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

S5R459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLAQLYYK YGTMNSGKTI EILKVAHNYE EQGKPVIIMT SALDTRDGYG
60 70 80 90 100
IVSSRIGMRR EAIAITNEMD VFAYVKALPE KPYCVLIDEC QFLTKKHVYE
110 120 130 140 150
LARVVDELEV PVMAFGLKND FQNELFEGSK YLLLLADKID EIKTICQFCS
160 170 180 190
KKATMVLRTE NGKPVYEGDQ IQIGGNETYI PVCRKHYFNP MISTEK
Length:196
Mass (Da):22,373
Last modified:October 16, 2013 - v1
Checksum:i5BC2D9B1F60BF112
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003025 Genomic DNA Translation: AGS05395.1

Genome annotation databases

EnsemblBacteriaiAGS05395; AGS05395; KE3_0900
KEGGislu:KE3_0900
PATRICifig|1076934.5.peg.845

Similar proteinsi

Entry informationi

Entry nameiS5R459_9STRE
AccessioniPrimary (citable) accession number: S5R459
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: May 23, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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