S5R459 (S5R459_9STRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP-Rule MF_00124 RuleBase RU000544
EC=2.7.1.21 HAMAP-Rule MF_00124 RuleBase RU000544

Gene names

Name:	tdk HAMAP-Rule MF_00124
ORF Names:	KE3_0900 EMBL AGS05395.1

Organism

Streptococcus lutetiensis 033 [Complete proteome] EMBL AGS05395.1

Taxonomic identifier

1076934 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus lutetiensis

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00124 SAAS SAAS020634
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00124 SAAS SAAS020634.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP-Rule MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634
Cellular component	Cytoplasm HAMAP-Rule MF_00124 SAAS SAAS020634
Ligand	ATP-binding HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634 Metal-binding HAMAP-Rule MF_00124 SAAS SAAS020634 Nucleotide-binding Zinc HAMAP-Rule MF_00124 SAAS SAAS020634
Molecular function	Kinase HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634 EMBL AGS05395.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-HAMAP thymidine kinase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	12 – 19	8	ATP By similarity HAMAP-Rule MF_00124
	Nucleotide binding	88 – 91	4	ATP By similarity HAMAP-Rule MF_00124
Sites
	Active site	89	1	Proton acceptor By similarity HAMAP-Rule MF_00124
	Metal binding	146	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	149	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	183	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	186	1	Zinc By similarity HAMAP-Rule MF_00124

Sequences

	Sequence		Length	Mass (Da)
	S5R459 [UniParc]. Last modified October 16, 2013. Version 1. Checksum: 5BC2D9B1F60BF112	FASTA	196	22,373
	10 20 30 40 50 60 MSLLAQLYYK YGTMNSGKTI EILKVAHNYE EQGKPVIIMT SALDTRDGYG IVSSRIGMRR 70 80 90 100 110 120 EAIAITNEMD VFAYVKALPE KPYCVLIDEC QFLTKKHVYE LARVVDELEV PVMAFGLKND 130 140 150 160 170 180 FQNELFEGSK YLLLLADKID EIKTICQFCS KKATMVLRTE NGKPVYEGDQ IQIGGNETYI 190 PVCRKHYFNP MISTEK

References

[1]

"Dynamics of fecal microbial communities in children with diarrhea of unknown etiology and genomic analysis of associated Streptococcus lutetiensis." Jin D., Chen C., Li L., Lu S., Li Z., Zhou Z., Jing H., Xu Y., Du P., Wang H., Xiong Y., Zheng H., Bai X., Sun H., Wang L., Ye C., Gottschalk M., Xu J. BMC Microbiol. 13:141-141(2013) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 033 EMBL AGS05395.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003025 Genomic DNA. Translation: AGS05395.1.
RefSeq	YP_008356203.1. NC_021900.1.
3D structure databases
ModBase	Search...
MobiDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AGS05395; AGS05395; KE3_0900.
GeneID	16434565.
KEGG	slu:KE3_0900.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00857.
Family and domain databases
Gene3D	3.40.50.300. 1 hit.
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

S5R459_9STRE

Accession

Primary (citable) accession number: S5R459

Entry history

Integrated into UniProtKB/TrEMBL:	October 16, 2013
Last sequence update:	October 16, 2013
Last modified:	June 11, 2014
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)