UniProtKB - S5R459 (S5R459_9STRE)
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Protein
Thymidine kinase
Gene
tdk
Organism
Streptococcus lutetiensis 033
Status
Functioni
Catalytic activityi
ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 89 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 146 | ZincUniRule annotation | 1 | |
Metal bindingi | 149 | ZincUniRule annotation | 1 | |
Metal bindingi | 183 | ZincUniRule annotation | 1 | |
Metal bindingi | 186 | ZincUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 19 | ATPUniRule annotation | 8 | |
Nucleotide bindingi | 88 – 91 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- thymidine kinase activity Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | KinaseUniRule annotationImported, Transferase |
Biological process | DNA synthesisUniRule annotation |
Ligand | ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tdkUniRule annotation ORF Names:KE3_0900Imported |
Organismi | Streptococcus lutetiensis 033Imported |
Taxonomic identifieri | 1076934 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Homotetramer.UniRule annotation
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidine kinase family.UniRule annotation
Phylogenomic databases
KOi | K00857. |
OrthoDBi | POG091H0659. |
Family and domain databases
HAMAPi | MF_00124. Thymidine_kinase. 1 hit. |
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. |
PANTHERi | PTHR11441. PTHR11441. 1 hit. |
Pfami | View protein in Pfam PF00265. TK. 1 hit. |
PIRSFi | PIRSF035805. TK_cell. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS00603. TK_CELLULAR_TYPE. 1 hit. |
i Sequence
Sequence statusi: Complete.
S5R459-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLLAQLYYK YGTMNSGKTI EILKVAHNYE EQGKPVIIMT SALDTRDGYG
60 70 80 90 100
IVSSRIGMRR EAIAITNEMD VFAYVKALPE KPYCVLIDEC QFLTKKHVYE
110 120 130 140 150
LARVVDELEV PVMAFGLKND FQNELFEGSK YLLLLADKID EIKTICQFCS
160 170 180 190
KKATMVLRTE NGKPVYEGDQ IQIGGNETYI PVCRKHYFNP MISTEK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP003025 Genomic DNA. Translation: AGS05395.1. |
Genome annotation databases
EnsemblBacteriai | AGS05395; AGS05395; KE3_0900. |
KEGGi | slu:KE3_0900. |
PATRICi | fig|1076934.5.peg.845. |
Similar proteinsi
Entry informationi
Entry namei | S5R459_9STRE | |
Accessioni | S5R459Primary (citable) accession number: S5R459 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 16, 2013 |
Last sequence update: | October 16, 2013 | |
Last modified: | March 28, 2018 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |