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Protein
Submitted name:

Toll-like receptor 2

Gene

TLR2

Organism
Pan troglodytes ellioti
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorSAAS annotationImported
Biological processImmunity, Innate immunitySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 2Imported
Gene namesi
Name:TLR2Imported
OrganismiPan troglodytes elliotiImported
Taxonomic identifieri756884 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei589 – 612HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500772700221 – 784Sequence analysisAdd BLAST764

Structurei

3D structure databases

ProteinModelPortaliS5PMW4.
SMRiS5PMW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini639 – 784TIRInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the Toll-like receptor family.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
PANTHERiPTHR24365:SF487. PTHR24365:SF487. 1 hit.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Complete.

S5PMW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL
60 70 80 90 100
TEAVKSLDLS NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG
110 120 130 140 150
SLEHLDLSYN YLSNLSSSWF KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK
160 170 180 190 200
LQILRVGNMD TFTKIQRKDF AGLTFLEELE IDASDLQSYE PKSLKSIQNV
210 220 230 240 250
SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFRFS ELSTGETNSL
260 270 280 290 300
IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN
310 320 330 340 350
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL
360 370 380 390 400
VPCLLSQHLK SLEYLDLSEN LIVEEYLKNS ACEDAWPSLQ TLILRQNHLA
410 420 430 440 450
SLEKTGETLL TLKNLTNVDI SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS
460 470 480 490 500
VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK ELYISRNKLM TLPDASLLPM
510 520 530 540 550
LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE FLSFTQEQQA
560 570 580 590 600
LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL
610 620 630 640 650
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER
660 670 680 690 700
DAYWVENLMV QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILILLEPI EKKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA AIKS
Length:784
Mass (Da):89,825
Last modified:October 16, 2013 - v1
Checksum:i9F46005D894F7CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF319744 Genomic DNA. Translation: AGR82448.1.
KF319745 Genomic DNA. Translation: AGR82449.1.
KF319746 Genomic DNA. Translation: AGR82450.1.
KF319747 Genomic DNA. Translation: AGR82451.1.
KF319748 Genomic DNA. Translation: AGR82452.1.
KF319749 Genomic DNA. Translation: AGR82453.1.
KF319750 Genomic DNA. Translation: AGR82454.1.
KF319751 Genomic DNA. Translation: AGR82455.1.
KF319752 Genomic DNA. Translation: AGR82456.1.
KF319753 Genomic DNA. Translation: AGR82457.1.
KF319754 Genomic DNA. Translation: AGR82458.1.
KF319755 Genomic DNA. Translation: AGR82459.1.
KF319756 Genomic DNA. Translation: AGR82460.1.

Similar proteinsi

Entry informationi

Entry nameiS5PMW4_PANTR
AccessioniPrimary (citable) accession number: S5PMW4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: August 30, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)