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Protein

NAD kinase

Gene

nadK

Organism
Lactobacillus reuteri TD1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotationSAAS annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei147NADUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei184NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi121 – 122NADUniRule annotation2
Nucleotide bindingi160 – 165NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotationSAAS annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
ORF Names:N134_03140Imported
OrganismiLactobacillus reuteri TD1Imported
Taxonomic identifieri1358027 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000015085 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliS5NAC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00858.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 2 hits.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_N.
IPR017437. ATP-NAD_kinase_PpnK-typ_C.
IPR016064. NAD/diacylglycerol_kinase_sf.
IPR002504. NADK.
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiView protein in Pfam
PF01513. NAD_kinase. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

S5NAC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGIYNNET AESQRVTKVL KTEMKRAGLT YVEKNPEVVI TIGGDGTLLS
60 70 80 90 100
AFHHYQKDLN NIRFVGIHTG HLGFYTDWRS FEIDDLVDSL VKDSGQAVSY
110 120 130 140 150
PLLAMKATYS DGQIENYIAL NESTIRNVTR TMVCDVFINN HLFENFRGDG
160 170 180 190 200
LCISTPTGST AYNKSVGGAI VDPNSVGFQL AEMASLNNRV FRTLGSPIIF
210 220 230 240 250
GADAELILRL RDENGHVLTC DRDQWMLKSE KERYLTELSY RVSKQRIYFA
260 270
QYRHNNFWNR VKDSFIGGVH
Length:270
Mass (Da):30,651
Last modified:October 16, 2013 - v1
Checksum:i1A6634E85CAD7E11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006603 Genomic DNA. Translation: AGR64003.1.
RefSeqiWP_003672236.1. NC_021872.1.

Genome annotation databases

EnsemblBacteriaiAGR64003; AGR64003; N134_03140.
KEGGilrr:N134_03140.
PATRICifig|1358027.3.peg.594.

Similar proteinsi

Entry informationi

Entry nameiS5NAC5_LACRE
AccessioniPrimary (citable) accession number: S5NAC5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: February 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported