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S5BT66

- S5BT66_ALTMA

UniProt

S5BT66 - S5BT66_ALTMA

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Protein
Thymidine kinase
Gene
tdk, I634_13705
Organism
Alteromonas macleodii str. 'Ionian Sea U8'
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi147 – 1471Zinc By similarityUniRule annotation
Metal bindingi182 – 1821Zinc By similarityUniRule annotation
Metal bindingi185 – 1851Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi87 – 904ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:I634_13705Imported
OrganismiAlteromonas macleodii str. 'Ionian Sea U8'Imported
Taxonomic identifieri1300257 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000014904: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliS5BT66.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

S5BT66-1 [UniParc]FASTAAdd to Basket

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MAQLYFYYSA MNAGKSTSLL QSAYNYRERG MHSIIYTAAL DDRYGVGKVT    50
SRIGLQADAK LYSKDDDLFT SIRLDCEKRK PDCVFIDEAQ FLTKAQVRQL 100
VEAVDELDVP VLAYGLRTDF LGETFEGSHY LLAWADKLFE LKTVCHCGRK 150
ANFVVRLDEN GNAVKNGDQV QIGGNDTYES MCRKHFKALV WDE 193
Length:193
Mass (Da):21,939
Last modified:October 16, 2013 - v1
Checksum:i61EF049E3965C857
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004852 Genomic DNA. Translation: AGP94436.1.
RefSeqiYP_008176838.1. NC_021712.1.

Genome annotation databases

EnsemblBacteriaiAGP94436; AGP94436; I634_13705.
GeneIDi16086496.
KEGGiamao:I634_13705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004852 Genomic DNA. Translation: AGP94436.1 .
RefSeqi YP_008176838.1. NC_021712.1.

3D structure databases

ProteinModelPortali S5BT66.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGP94436 ; AGP94436 ; I634_13705 .
GeneIDi 16086496.
KEGGi amao:I634_13705.

Phylogenomic databases

KOi K00857.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic Diversity of "Deep Ecotype" Alteromonas macleodii Isolates: Evidence for Pan-Mediterranean Clonal Frames."
    Lopez-Perez M., Gonzaga A., Rodriguez-Valera F.
    Genome Biol. Evol. 5:1220-1232(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ionian Sea U8Imported.

Entry informationi

Entry nameiS5BT66_ALTMA
AccessioniPrimary (citable) accession number: S5BT66
Entry historyi
Integrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: June 11, 2014
This is version 7 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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