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Protein
Submitted name:

E3 ubiquitin-protein ligase parkin isoform

Gene

PARK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase parkin isoformImported
Gene namesi
Name:PARK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: InterPro
  2. mitochondrion Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiS4X465. baseline and differential.

Family & Domainsi

Keywords - Domaini

Zinc-fingerSAAS annotation

Family and domain databases

InterProiIPR003977. Parkin.
IPR002867. Znf_C6HC.
[Graphical view]
PfamiPF01485. IBR. 2 hits.
[Graphical view]
PIRSFiPIRSF037880. Parkin. 1 hit.
PRINTSiPR01475. PARKIN.
SMARTiSM00647. IBR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

S4X465-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNATGGDDPR NAAGGCEREP QSLTRVDLSS SVLPGDSVGL AVILHTDSRK
60 70 80 90 100
DSPPAGSPAG RSIYNSFYVY CKGPCQRVQP GKLRVQCSTC RQATLTLTQE
110 120 130 140 150
FFFKCGAHPT SDKETSVALH LIATNSRNIT CITCTDVRSP VLVFQCNSRH
160 170 180 190 200
VICLDCFHLY CVTRLNDRQF VHDPQLGYSL PCVAGCPNSL IKELHHFRIL
210 220 230 240 250
GEEQYNRYQQ YGAEECVLQM GGVLCPRPGC GAGLLPEPDQ RKVTCEGGNG
260 270 280 290 300
LGCGFAFCRE CKEAYHEGEC SAVFEASGTT TQAYRVDERA AEQARWEAAS
310 320 330 340 350
KETIKKTTKP CPRCHVPVEK NGGCMHMKCP QPQCRLEWCW NCGCEWNRVC

MGDHWFDV
Length:358
Mass (Da):39,593
Last modified:October 16, 2013 - v1
Checksum:i1380815F8E74A7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC774171 mRNA. Translation: AGP25366.1.
UniGeneiHs.132954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC774171 mRNA. Translation: AGP25366.1.
UniGeneiHs.132954.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

ExpressionAtlasiS4X465. baseline and differential.

Family and domain databases

InterProiIPR003977. Parkin.
IPR002867. Znf_C6HC.
[Graphical view]
PfamiPF01485. IBR. 2 hits.
[Graphical view]
PIRSFiPIRSF037880. Parkin. 1 hit.
PRINTSiPR01475. PARKIN.
SMARTiSM00647. IBR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "PARK2 alternative splice variant."
    D'Agata V., La Cognata V., Iemmolo R., Cavallaro S.
    Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiS4X465_HUMAN
AccessioniPrimary (citable) accession number: S4X465
Entry historyi
Integrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: October 29, 2014
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.