Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytidine deaminase

Gene

cdd

Organism
Escherichia coli KTE33
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotationSAAS annotation

Catalytic activityi

2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotationSAAS annotation
Cytidine + H2O = uridine + NH3.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Zinc; catalyticUniRule annotation1
Active sitei104Proton donorUniRule annotation1
Metal bindingi129Zinc; catalyticUniRule annotation1
Metal bindingi132Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
Alternative name(s):
Cytidine aminohydrolaseUniRule annotation
Short name:
CDAUniRule annotation
Gene namesi
Name:cddUniRule annotation
ORF Names:WEW_01300Imported
OrganismiEscherichia coli KTE33Imported
Taxonomic identifieri1169351 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000013993 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 168CMP/dCMP-type deaminaseInterPro annotationAdd BLAST121
Domaini186 – 294CMP/dCMP-type deaminaseInterPro annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 91Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01558. Cyt_deam. 1 hit.
InterProiView protein in InterPro
IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_dom.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
PfamiView protein in Pfam
PF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
SUPFAMiSSF53927. SSF53927. 2 hits.
TIGRFAMsiTIGR01355. cyt_deam_dimer. 1 hit.
PROSITEiView protein in PROSITE
PS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.

Sequencei

Sequence statusi: Complete.

R8XNH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRFQTAFA QLADNLQSAL EPILADKYFP ALLTKEQVSS LKSATGLDED
60 70 80 90 100
ALAFALLPLA AACARTPLSN FNVGAIARGV SGTWYFGANM EFIGATMQQT
110 120 130 140 150
VHAEQSAISH AWLSGEKALA AITVNYTPCG HCRQFMNELN SGLDLRIHLP
160 170 180 190 200
GREAHALRDY LPDAFGPKDL EIKTLLMDEQ DHGFALTGDA LSQAAIAAAN
210 220 230 240 250
RSHMPYSKSP SGVALECKDG RIFSGSYAEN AAFNPTLPPL QGALILLNLK
260 270 280 290
GYDYPDIQRA ILAEKADAPL IQWDATSATL KALGCNNIDR VLLA
Length:294
Mass (Da):31,613
Last modified:July 24, 2013 - v1
Checksum:iF2A318E701259459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ASQM01000123 Genomic DNA. Translation: EOQ58743.1.
RefSeqiWP_000553573.1. NZ_KB976076.1.

Genome annotation databases

EnsemblBacteriaiEOQ58743; EOQ58743; WEW_01300.
PATRICifig|1169351.3.peg.1226.

Similar proteinsi

Entry informationi

Entry nameiR8XNH4_ECOLX
AccessioniPrimary (citable) accession number: R8XNH4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: January 31, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported