ID   R7VSN8_COLLI            Unreviewed;       379 AA.
AC   R7VSN8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=NEU2 {ECO:0000313|EMBL:PKK20832.1};
GN   ORFNames=A306_00010594 {ECO:0000313|EMBL:PKK20832.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK20832.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK20832.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK20832.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKK20832.1}.
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DR   EMBL; AKCR02000099; PKK20832.1; -; Genomic_DNA.
DR   RefSeq; XP_005512782.1; XM_005512725.1.
DR   AlphaFoldDB; R7VSN8; -.
DR   STRING; 8932.R7VSN8; -.
DR   GeneID; 102098436; -.
DR   KEGG; clv:102098436; -.
DR   CTD; 4759; -.
DR   eggNOG; ENOG502QSFT; Eukaryota.
DR   InParanoid; R7VSN8; -.
DR   OrthoDB; 5482010at2759; -.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF6; SIALIDASE-2; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT   DOMAIN          46..338
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   379 AA;  43027 MW;  BA63F59C32913C05 CRC64;
     MASFPVLNQE TLFRNGTWSY RIPALLYLPR FSIILAFAEE REDLVDEHAK LIAMRRGIYN
     PITHHVQWKH MESIASAQLQ DHRSMNPTPV YDEVSGKLFL FFIAIPGQIS ELHQLRTKTN
     LVRLCYVTSM DHGCTWSNVQ DITNGTIGTE HKNWATFALG PGHGLQLLNE ARSLVIPAYA
     YRILDPNRQP IPHAFCFISS DHGVTWKMGN FVEGEGTVEC QVAEVHSCGR RVIYCNARGS
     RGARIQAVSY DDGEDFERGQ RVEKLVEPPL GCHGSVIAFP PPTYVRCRDS WLLFSHPTDP
     KSRRDLGIYL NKSPLNPSDW TKPSILFKGR CAYSDLQYMG LGPDGSPLFS CLFEYGTRQP
     YEEMIFVMFT LKQAFPSEC
//