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Protein
Submitted name:

Beta-crystallin B2

Gene

CRYBB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-crystallin B2Imported
Gene namesi
Name:CRYBB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381273.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 5640Beta/gamma crystallin 'Greek key'InterPro annotationAdd
BLAST
Domaini57 – 10145Beta/gamma crystallin 'Greek key'InterPro annotationAdd
BLAST
Domaini107 – 14842Beta/gamma crystallin 'Greek key'InterPro annotationAdd
BLAST
Domaini149 – 19143Beta/gamma crystallin 'Greek key'InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IJYD. Eukaryota.
ENOG410Y7P1. LUCA.
GeneTreeiENSGT00760000118812.
OMAiHELTGPC.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033058. CRYBB2.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF11. PTHR11818:SF11. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

R4UMM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASDHQTQAG KPQSLNPKII IFEQENFQGH SHELNGPCPN LKETGVEKAG
60 70 80 90 100
SVLVQAGPWV GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI
110 120 130 140 150
KVDSQEHKII LYENPNFTGK KMEIIDDDVP SFHAHGYQEK VSSVRVQSGT
160 170 180 190 200
WVGYQYPGYR GLQYLLEKGD YKDSSDFGAP HPQVQSVRRI RDMQWHQRGA

FHPSN
Length:205
Mass (Da):23,380
Last modified:July 24, 2013 - v1
Checksum:iFD95C354724A67D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC683809 Genomic DNA. Translation: AGM34047.1.
KR052784 mRNA. Translation: AKK25301.1.
KR052788 mRNA. Translation: AKK25302.1.
KR052790 mRNA. Translation: AKK25305.1.
RefSeqiNP_000487.1. NM_000496.2.
XP_006724204.1. XM_006724141.2.
XP_011528202.1. XM_011529900.1.
XP_011528203.1. XM_011529901.1.
UniGeneiHs.373074.

Genome annotation databases

GeneIDi1415.
KEGGihsa:1415.
UCSCiuc003abp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC683809 Genomic DNA. Translation: AGM34047.1.
KR052784 mRNA. Translation: AKK25301.1.
KR052788 mRNA. Translation: AKK25302.1.
KR052790 mRNA. Translation: AKK25305.1.
RefSeqiNP_000487.1. NM_000496.2.
XP_006724204.1. XM_006724141.2.
XP_011528202.1. XM_011529900.1.
XP_011528203.1. XM_011529901.1.
UniGeneiHs.373074.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1415.
KEGGihsa:1415.
UCSCiuc003abp.2. human.

Organism-specific databases

CTDi1415.

Phylogenomic databases

eggNOGiENOG410IJYD. Eukaryota.
ENOG410Y7P1. LUCA.
GeneTreeiENSGT00760000118812.
OMAiHELTGPC.

Miscellaneous databases

ChiTaRSiCRYBB2. human.
GenomeRNAii1415.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033058. CRYBB2.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF11. PTHR11818:SF11. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Chen M., Hu Z.
    Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Functional candidate gene approach to study genetic polymorphisms in lens specific genes."
    Rajkumar S., Ekta P.A., Vidya N.G., Vasavada A.R.
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Functional candidate gene approach to study genetic polymorphisms in lens specific genes."
    Rajkumar S., Ekta P.A., Vasavada A.R.
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiR4UMM2_HUMAN
AccessioniPrimary (citable) accession number: R4UMM2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2013
Last sequence update: July 24, 2013
Last modified: June 8, 2016
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.