ID   R4LFH7_ACTS9            Unreviewed;       397 AA.
AC   R4LFH7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   ORFNames=L083_3658 {ECO:0000313|EMBL:AGL17168.1};
OS   Actinoplanes sp. (strain N902-109).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=649831 {ECO:0000313|EMBL:AGL17168.1, ECO:0000313|Proteomes:UP000013541};
RN   [1] {ECO:0000313|EMBL:AGL17168.1, ECO:0000313|Proteomes:UP000013541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N902-109 {ECO:0000313|EMBL:AGL17168.1,
RC   ECO:0000313|Proteomes:UP000013541};
RA   Hu H., Huang H., Lu X., Zhu B.;
RT   "Comparative analysis of rapamycin biosynthesis clusters between
RT   Streptomyces hygroscopicus ATCC 29253 and Actinoplanes sp. N902-109.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP005929; AGL17168.1; -; Genomic_DNA.
DR   RefSeq; WP_015621726.1; NC_021191.1.
DR   AlphaFoldDB; R4LFH7; -.
DR   STRING; 649831.L083_3658; -.
DR   KEGG; actn:L083_3658; -.
DR   PATRIC; fig|649831.3.peg.3604; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000013541; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:AGL17168.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013541};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          58..362
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   397 AA;  42788 MW;  CC912BA321328B5A CRC64;
     MTLILRCLVA LSLIVAGPSK GPQQHSETLL FDGGGETLNG TTYHSFRIPS LLRTTKDSLL
     AFAEGRTESN RDHGNINLMV KRSTDDGATW SGLGQVVGTG QGTWGNPTAV VDRDTGTIFL
     FVSWNAAGLS QDGADGTTRI SAWGERRVRL FTSSKDEDGT VWHGPADLTE AVTPRKHADG
     SDWAWDAVGP GAGIQTSSGR LLVPATNRTI YSDDHGKTFH SAPMARGQEV TGESTLLELT
     DGRLMRNDTA VMSTWETAKN RWVARGTIEG GFDAYAPDPH LPDPHAEASI LRYNLDTTPR
     IIFLNSASSV NRRAMTIRVS TDEGVTWPVS RRLSDAPMPA WPQLGSANVV EGGYSSLAKT
     ANKQVGALVE VNENADASDT SHRSIVFRTM NLPWITG
//