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Protein
Submitted name:

Adenomatous polyposis coli protein

Gene

APC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Adenomatous polyposis coli proteinImported
Gene namesi
Name:APCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000134982.16
HGNCiHGNC:583 APC

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134982

PTM / Processingi

Proteomic databases

MaxQBiR4GMU6
PeptideAtlasiR4GMU6
PRIDEiR4GMU6

Expressioni

Gene expression databases

BgeeiENSG00000134982
ExpressionAtlasiR4GMU6 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati223 – 265ARMPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 113Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000063749

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026818 Apc_fam
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PANTHERiPTHR12607 PTHR12607, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 2 hits
SMARTiView protein in SMART
SM00185 ARM, 5 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

Sequencei

Sequence statusi: Fragment.

R4GMU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSFDEEHRHA MNELGRKATR GISSQELGQG LSGGLQAIAE LLQVDCEMYG
60 70 80 90 100
LTNDHYSITL RRYAGMALTN LTFGDVANKA TLCSMKGCMR ALVAQLKSES
110 120 130 140 150
EDLQQVIASV LRNLSWRADV NSKKTLREVG SVKALMECAL EVKKESTLKS
160 170 180 190 200
VLSALWNLSA HCTENKADIC AVDGALAFLV GTLTYRSQTN TLAIIESGGG
210 220 230 240 250
ILRNVSSLIA TNEDHRQILR ENNCLQTLLQ HLKSHSLTIV SNACGTLWNL
260 270
SARNPKDQEA LWDMGAVSML KN
Length:272
Mass (Da):29,737
Last modified:June 26, 2013 - v1
Checksum:iD349657B223A8A35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei272Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008575 Genomic DNA No translation available.
AC136500 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000504915; ENSP00000473355; ENSG00000134982
UCSCiuc063gas.1 human

Similar proteinsi

Entry informationi

Entry nameiR4GMU6_HUMAN
AccessioniPrimary (citable) accession number: R4GMU6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health