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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Hippopotamus amphibius (Hippopotamus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiHippopotamus amphibius (Hippopotamus)
Taxonomic identifieri9833 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaHippopotamidaeHippopotamus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei211 – 233HelicalSequence analysisAdd BLAST23
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei325 – 347HelicalSequence analysisAdd BLAST23
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001180991 – 594NADH-ubiquinone oxidoreductase chain 5Add BLAST594

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZZY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFSSTTLT MLFVLTLPIM MTNTNIYKSD KYPTYVKNTV SSAFLISLVP
60 70 80 90 100
MIAFTNTGQE MIISNWHWIT IQTLKLTLSF KADYFSIVFA PVALFVTWSI
110 120 130 140 150
MEFSMWYMHS DPHINQFFKY LLLFLITMMI LVTANNLFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWHG RTDANTAAIQ AILYNRIGDV GFIMAMAWFL SNLNTWDMQQ
210 220 230 240 250
IFMINPTHSN LPLMGLILAA TGKSAQFGLH PWLPSAMEGP TPVSALLHSS
260 270 280 290 300
TMVVAGVFLL IRFYPMMENN NLMQTITMCL GAITTLFTAM CALTQNDIKK
310 320 330 340 350
IIAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL
360 370 380 390 400
NNEQDIRKMG GLFKTMPFTT TTLIVGSMAL TGVPFLTGFY SKDLIIEAAN
410 420 430 440 450
TSYSNAWALL ITLVATSLTA VYSTRIIFFA LLGHPRFPTS TLIHENNPLL
460 470 480 490 500
LNSLKRLMAG SIFAGFILSH NLPPMTTPLM TMPPYLKMTA LAVTMLGFTL
510 520 530 540 550
AFEITLNTQN LKYKHPTNSF KFSTLLGYFP TIMHRLPPHL SLTASQKLAS
560 570 580 590
SLLDSAWLEN ILPKSMAHAQ LKLSTLVSNQ KGLMKMYFSI IPYH
Length:594
Mass (Da):66,599
Last modified:May 1, 1999 - v1
Checksum:i4130499096B5A5CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010957 Genomic DNA. Translation: CAA09438.1.
RefSeqiNP_008800.1. NC_000889.1.

Genome annotation databases

GeneIDi808681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010957 Genomic DNA. Translation: CAA09438.1.
RefSeqiNP_008800.1. NC_000889.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808681.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_HIPAM
AccessioniPrimary (citable) accession number: Q9ZZY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 16, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.