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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Cyanidioschyzon merolae (Red alga)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation
Gene namesi
Name:cox2Imported
Encoded oniMitochondrionImported
OrganismiCyanidioschyzon merolae (Red alga)Imported
Taxonomic identifieri45157 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidioschyzon

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Transmembranei90 – 11223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi45157.CMW010CT.

Structurei

3D structure databases

ProteinModelPortaliQ9ZZQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11896COX2_TMInterPro annotationAdd
BLAST
Domaini119 – 257139COX2_CUAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
OMAiPLKIFEM.
PhylomeDBiQ9ZZQ9.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZZQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVNTIVIF LITFGYEVIY NDAPVLWQTG FQDPATPVME GIINLHHDFI
60 70 80 90 100
FFFILIFVFV LWILLRAIYF FNSRVNKVAI NYSHGTLIEL IWTIIPIMIL
110 120 130 140 150
MTIAVPSFAL LYSIDEIINP AVTVKAVGHQ WYWSYEYSDY IGENGEIINF
160 170 180 190 200
DSYIIPEEDL EIGQFRLLEV DNRIIVPVNT HVRVIVTSAD VIHSWAVPSL
210 220 230 240 250
GVKCDGIPGR LNQISLFIKR EGVYYGQCSE LCGVNHGFIP IVVEAVPLDN
260
YIDWIQKKLY A
Length:261
Mass (Da):29,912
Last modified:May 1, 1999 - v1
Checksum:iD31DC51153FE71E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89861 Genomic DNA. Translation: BAA34656.1.
PIRiE58930.
RefSeqiNP_059353.1. NC_000887.3.

Genome annotation databases

EnsemblPlantsiCMW010CT; CMW010CT; CMW010C.
GeneIDi3125647.
GrameneiCMW010CT; CMW010CT; CMW010C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89861 Genomic DNA. Translation: BAA34656.1.
PIRiE58930.
RefSeqiNP_059353.1. NC_000887.3.

3D structure databases

ProteinModelPortaliQ9ZZQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi45157.CMW010CT.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiCMW010CT; CMW010CT; CMW010C.
GeneIDi3125647.
GrameneiCMW010CT; CMW010CT; CMW010C.

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
OMAiPLKIFEM.
PhylomeDBiQ9ZZQ9.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ZZQ9_CYAME
AccessioniPrimary (citable) accession number: Q9ZZQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.