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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223HelicalSequence analysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11320HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13923HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Transmembranei285 – 30420HelicalSequence analysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence analysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence analysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence analysisAdd
BLAST
Transmembranei436 – 45621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460NADH-ubiquinone oxidoreductase chain 4PRO_0000117984Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZZM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKILIPTLM LFPTIWFSPA KWLWTTSIAQ SLVIALASLS WLKWSSETGW
60 70 80 90 100
SSSNLYLATD PLSTPLLVLT CWLLPLMVLA SQNHISPEPL NRQRTYISLL
110 120 130 140 150
VSLQMFLILA FGATEIIMFY IMFEATLLPT LIIITRWGNQ TERLNAGTYF
160 170 180 190 200
LFYTLAGSLP LLVALLLLQN DSGTLSMFTL QYTQPMHLLT WGNKLWWAAC
210 220 230 240 250
LLAFLVKMPV YGVHLWLPKA HVEAPIAGSM ILAAVLLKLG GYGMMRMMVM
260 270 280 290 300
LDPLTKELAY PFIVLALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAG
310 320 330 340 350
GILIQTPWGF TGAIILMIAH GLASSALFCL ANTSYERTHS RTMLLARGMQ
360 370 380 390 400
MILPLMTTWW FVASLANLAL PPLPNLMGEL MIITSMFNWS HWTLLLTGLG
410 420 430 440 450
TLITASYSLY LFLMTQRGPL PSHIIALEPT HTREHLLITL HLIPIILLIL
460
KPELMWGWCF
Length:460
Mass (Da):51,552
Last modified:May 1, 1999 - v1
Checksum:i2919547E0DDC72EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931N → D in AAF61387 (Ref. 2) Curated
Sequence conflicti210 – 2101V → L in AAF61387 (Ref. 2) Curated
Sequence conflicti353 – 3531L → V in AAF61387 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12143 Genomic DNA. Translation: AAD04742.1.
AF133701 Genomic DNA. Translation: AAF61387.1.
PIRiT09956.
RefSeqiNP_008454.1. NC_001960.1.

Genome annotation databases

GeneIDi808305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12143 Genomic DNA. Translation: AAD04742.1.
AF133701 Genomic DNA. Translation: AAF61387.1.
PIRiT09956.
RefSeqiNP_008454.1. NC_001960.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808305.

Organism-specific databases

CTDi4538.

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo salar."
    Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.
    Gene 239:237-242(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "The complete mitochondrial genome sequence of a teleost, Salmo salar, and comparisons with other salmoniformes."
    Arnason U., Johnsson E., Rasmussen A.S.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU4M_SALSA
AccessioniPrimary (citable) accession number: Q9ZZM4
Secondary accession number(s): Q9MPG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 16, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.