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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Transmembranei463 – 48321HelicalSequence analysisAdd
BLAST
Transmembranei494 – 51421HelicalSequence analysisAdd
BLAST
Transmembranei591 – 61121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612NADH-ubiquinone oxidoreductase chain 5PRO_0000118146Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZZM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPTTLILSS TLLMIFALLL YPLITTLNPT PQQENWALTH VKTAIKMAFL
60 70 80 90 100
VSLLPLFIFL DQGTETIVTN WQWMNTTTFD INLSFKFDHY SIIFTPIALY
110 120 130 140 150
VTWSILEFAS WYMHADPNMN RFFKYLLLFL IAMIILVTAN NMFQLFIGWE
160 170 180 190 200
GVGIMSFLLI GWWYGRADAN TAAMQAVIYN RVGDIGLILS MAWFATNLNS
210 220 230 240 250
WEIQQMFASS KELDLTLPLM GLILAATGKS AQFGLHPWLP SAMEGPTPVS
260 270 280 290 300
ALLHSSTMVV AGIFLLIRLH PLMENNQTAL TTCLCLGALT TLFTATCALT
310 320 330 340 350
QNDIKKIVAF STSSQLGLMM VTIGLNQPQL AFLHICTHAF FKAMLFLCSG
360 370 380 390 400
SIIHSLNDEQ DIRKMGGMHN LTPFTSSCLT IGSLALTGTP FLAGFFSKDA
410 420 430 440 450
IIEALNTSHL NAWALTLTLL ATSFTAVYSL RVVFFVSMGH PRFTATAPIN
460 470 480 490 500
ENNPSVINPI KRLAWGSIIA GLLITSNFLP SKTPIMTMPL PLKLAALLVT
510 520 530 540 550
ISGLLIALEL ASLTNKQFKT TPNLITHNFS NMLGFFPAII HRLAPKLNLT
560 570 580 590 600
LGQTIASQMV DQTWFEKIGP KGVVSTHLPM VTTTSNIQQG MIKTYLTLFF
610
LSTALAVLLT LT
Length:612
Mass (Da):67,610
Last modified:May 1, 1999 - v1
Checksum:i58C99457196E405E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771V → M in AAF61388 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12143 Genomic DNA. Translation: AAD04743.1.
AF133701 Genomic DNA. Translation: AAF61388.1.
PIRiT09957.
RefSeqiNP_008455.1. NC_001960.1.

Genome annotation databases

GeneIDi808309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12143 Genomic DNA. Translation: AAD04743.1.
AF133701 Genomic DNA. Translation: AAF61388.1.
PIRiT09957.
RefSeqiNP_008455.1. NC_001960.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808309.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_SALSA
AccessioniPrimary (citable) accession number: Q9ZZM3
Secondary accession number(s): Q9MPG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 16, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.