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Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Iron (heme A axial ligand)Curated1
Metal bindingi244Copper BCurated1
Metal bindingi290Copper BCurated1
Metal bindingi291Copper BCurated1
Metal bindingi376Iron (heme A3 axial ligand)Curated1
Metal bindingi378Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei12 – 40Helical; Name=IBy similarityAdd BLAST29
Topological domaini41 – 50Mitochondrial intermembraneBy similarity10
Transmembranei51 – 86Helical; Name=IIBy similarityAdd BLAST36
Topological domaini87 – 94Mitochondrial matrixBy similarity8
Transmembranei95 – 117Helical; Name=IIIBy similarityAdd BLAST23
Topological domaini118 – 140Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei141 – 170Helical; Name=IVBy similarityAdd BLAST30
Topological domaini171 – 182Mitochondrial matrixBy similarityAdd BLAST12
Transmembranei183 – 212Helical; Name=VBy similarityAdd BLAST30
Topological domaini213 – 227Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei228 – 261Helical; Name=VIBy similarityAdd BLAST34
Topological domaini262 – 269Mitochondrial matrixBy similarity8
Transmembranei270 – 286Helical; Name=VIIBy similarityAdd BLAST17
Topological domaini287 – 298Mitochondrial intermembraneBy similarityAdd BLAST12
Transmembranei299 – 327Helical; Name=VIIIBy similarityAdd BLAST29
Topological domaini328 – 335Mitochondrial matrixBy similarity8
Transmembranei336 – 357Helical; Name=IXBy similarityAdd BLAST22
Topological domaini358 – 370Mitochondrial intermembraneBy similarityAdd BLAST13
Transmembranei371 – 400Helical; Name=XBy similarityAdd BLAST30
Topological domaini401 – 406Mitochondrial matrixBy similarity6
Transmembranei407 – 433Helical; Name=XIBy similarityAdd BLAST27
Topological domaini434 – 446Mitochondrial intermembraneBy similarityAdd BLAST13
Transmembranei447 – 478Helical; Name=XIIBy similarityAdd BLAST32
Topological domaini479 – 514Mitochondrial matrixBy similarityAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832991 – 514Cytochrome c oxidase subunit 1Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiQ9ZZ64.

Interactioni

Subunit structurei

As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030311.

Structurei

3D structure databases

ProteinModelPortaliQ9ZZ64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4769. Eukaryota.
COG0843. LUCA.
GeneTreeiENSGT00390000001518.
HOGENOMiHOG000085274.
HOVERGENiHBG003841.
InParanoidiQ9ZZ64.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG091G035B.
TreeFamiTF353096.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZZ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD
60 70 80 90 100
DQIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL
160 170 180 190 200
HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVLI TAVLLLLSLP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFAHWFPLF
410 420 430 440 450
SGYTLNDTWA KIHFTIMFVG VNMTFFPQHF LGLSGMPRRY SDYPDAYTTW
460 470 480 490 500
NTVSSMGSFI SLTAVMLMIF MIWEAFASKR EVAMVELTTT NIEWLHGCPP
510
PYHTFEEPTY VIQK
Length:514
Mass (Da):57,039
Last modified:August 14, 2001 - v2
Checksum:i44D2B3E8E04CBF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96639 Genomic DNA. Translation: AAD04765.2.
AY729880 Genomic DNA. Translation: AAU12151.1.
PIRiT11495.
RefSeqiNP_008473.4. NC_002008.4.

Genome annotation databases

EnsembliENSCAFT00000034830; ENSCAFP00000030311; ENSCAFG00000022723.
GeneIDi804478.
KEGGicfa:804478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96639 Genomic DNA. Translation: AAD04765.2.
AY729880 Genomic DNA. Translation: AAU12151.1.
PIRiT11495.
RefSeqiNP_008473.4. NC_002008.4.

3D structure databases

ProteinModelPortaliQ9ZZ64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030311.

Proteomic databases

PaxDbiQ9ZZ64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000034830; ENSCAFP00000030311; ENSCAFG00000022723.
GeneIDi804478.
KEGGicfa:804478.

Organism-specific databases

CTDi4512.

Phylogenomic databases

eggNOGiKOG4769. Eukaryota.
COG0843. LUCA.
GeneTreeiENSGT00390000001518.
HOGENOMiHOG000085274.
HOVERGENiHBG003841.
InParanoidiQ9ZZ64.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG091G035B.
TreeFamiTF353096.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_CANLF
AccessioniPrimary (citable) accession number: Q9ZZ64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 14, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.