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Q9ZZ64

- COX1_CANFA

UniProt

Q9ZZ64 - COX1_CANFA

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Protein

Cytochrome c oxidase subunit 1

Gene
MT-CO1, COI, COXI, MTCO1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Mitochondrial matrix By similarityAdd
BLAST
Transmembranei12 – 4029Helical; Name=I; By similarityAdd
BLAST
Topological domaini41 – 5010Mitochondrial intermembrane By similarity
Transmembranei51 – 8636Helical; Name=II; By similarityAdd
BLAST
Topological domaini87 – 948Mitochondrial matrix By similarity
Transmembranei95 – 11723Helical; Name=III; By similarityAdd
BLAST
Topological domaini118 – 14023Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei141 – 17030Helical; Name=IV; By similarityAdd
BLAST
Topological domaini171 – 18212Mitochondrial matrix By similarityAdd
BLAST
Transmembranei183 – 21230Helical; Name=V; By similarityAdd
BLAST
Topological domaini213 – 22715Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei228 – 26134Helical; Name=VI; By similarityAdd
BLAST
Topological domaini262 – 2698Mitochondrial matrix By similarity
Transmembranei270 – 28617Helical; Name=VII; By similarityAdd
BLAST
Topological domaini287 – 29812Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei299 – 32729Helical; Name=VIII; By similarityAdd
BLAST
Topological domaini328 – 3358Mitochondrial matrix By similarity
Transmembranei336 – 35722Helical; Name=IX; By similarityAdd
BLAST
Topological domaini358 – 37013Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei371 – 40030Helical; Name=X; By similarityAdd
BLAST
Topological domaini401 – 4066Mitochondrial matrix By similarity
Transmembranei407 – 43327Helical; Name=XI; By similarityAdd
BLAST
Topological domaini434 – 44613Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei447 – 47832Helical; Name=XII; By similarityAdd
BLAST
Topological domaini479 – 51436Mitochondrial matrix By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000183299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030311.

Structurei

3D structure databases

ProteinModelPortaliQ9ZZ64.
SMRiQ9ZZ64. Positions 1-511.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
GeneTreeiENSGT00390000001518.
HOGENOMiHOG000085274.
HOVERGENiHBG003841.
InParanoidiQ9ZZ64.
KOiK02256.
OMAiGRHEIET.
OrthoDBiEOG7Q8CMW.
TreeFamiTF353096.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZZ64-1 [UniParc]FASTAAdd to Basket

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MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD    50
DQIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL 150
HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVLI TAVLLLLSLP 200
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV 350
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFAHWFPLF 400
SGYTLNDTWA KIHFTIMFVG VNMTFFPQHF LGLSGMPRRY SDYPDAYTTW 450
NTVSSMGSFI SLTAVMLMIF MIWEAFASKR EVAMVELTTT NIEWLHGCPP 500
PYHTFEEPTY VIQK 514
Length:514
Mass (Da):57,039
Last modified:August 14, 2001 - v2
Checksum:i44D2B3E8E04CBF6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96639 Genomic DNA. Translation: AAD04765.2.
AY729880 Genomic DNA. Translation: AAU12151.1.
PIRiT11495.
RefSeqiNP_008473.4. NC_002008.4.

Genome annotation databases

EnsembliENSCAFT00000034830; ENSCAFP00000030311; ENSCAFG00000022723.
GeneIDi804478.
KEGGicfa:804478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96639 Genomic DNA. Translation: AAD04765.2 .
AY729880 Genomic DNA. Translation: AAU12151.1 .
PIRi T11495.
RefSeqi NP_008473.4. NC_002008.4.

3D structure databases

ProteinModelPortali Q9ZZ64.
SMRi Q9ZZ64. Positions 1-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000030311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000034830 ; ENSCAFP00000030311 ; ENSCAFG00000022723 .
GeneIDi 804478.
KEGGi cfa:804478.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

eggNOGi COG0843.
GeneTreei ENSGT00390000001518.
HOGENOMi HOG000085274.
HOVERGENi HBG003841.
InParanoidi Q9ZZ64.
KOi K02256.
OMAi GRHEIET.
OrthoDBi EOG7Q8CMW.
TreeFami TF353096.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

NextBioi 20934083.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the domestic dog (Canis familiaris) mitochondrial genome."
    Kim K.S., Lee S.E., Jeong H.W., Ha J.H.
    Mol. Phylogenet. Evol. 10:210-220(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Kim K.S., Lee S.E., Jeong H.W., Jeong S.Y., Sohn H.S., Ha J.H.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 240; 323 AND 479.
  3. "The complete mitochondrial DNA sequence of the Beagle dog (Canis familiaris)."
    Zhu S., Xu Q., Chang H.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_CANFA
AccessioniPrimary (citable) accession number: Q9ZZ64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 14, 2001
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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