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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence analysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence analysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence analysisAdd
BLAST
Transmembranei457 – 47721HelicalSequence analysisAdd
BLAST
Transmembranei488 – 50821HelicalSequence analysisAdd
BLAST
Transmembranei582 – 60221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606NADH-ubiquinone oxidoreductase chain 5PRO_0000118073Add
BLAST

Proteomic databases

PaxDbiQ9ZZ57.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030319.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4668. Eukaryota.
COG1009. LUCA.
HOGENOMiHOG000100570.
HOVERGENiHBG108343.
InParanoidiQ9ZZ57.
KOiK03883.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZZ57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMFSSCMIT ALVILTLPII MSSTKLYKNK LYPYYVKTAT SYAFMISMIP
60 70 80 90 100
TMMFIYSGQE TIFSNWHWMT IQTMKLSMSF KLNYFSMIFV PVALFVTWSI
110 120 130 140 150
MEFSMWYMHS DPYINRFFKY LLLFLITMMV LVTANNMFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWYG RTDANTAALQ AVLYNRIGDV GFIMTMAWFL LNLNTWDLQQ
210 220 230 240 250
IFITTNDNFN LPLLGLLLAA TGKSAQFGLH PWLPSAMEGP TPVSALLHSS
260 270 280 290 300
TMVVAGVFLL IRFHPLMEHN QTIQTLTLCL GAITTLFTAI CALTQNDIKE
310 320 330 340 350
IVSFSTSSQL GLMMVTIGIN QPYLAFLHIC THAFCKAMLF MCSGSVIHSL
360 370 380 390 400
NDEQDIRKMG GLFKVLPFTT TSLIIGSLAL TGMPFLTGFY SKDLIIESAN
410 420 430 440 450
TSNTNAWALL ITLVATSLTA AYSTRIMFFA LLGQPRFSPM ILINENNPLL
460 470 480 490 500
INSIKRLLIG SVFAGYIISH SITPTTIPQM TMPHYLKMTA LAVTILGFIL
510 520 530 540 550
ALELNLTTQG LKFNYPSNYF KFSSLLGYYP TIMHRLTPKT SLTISQKSAS
560 570 580 590 600
MLLDSIWLEN ILPKSISYFQ MKSSTLISNQ KGLIKLYFLS FMLTMILSLL

ILNYHE
Length:606
Mass (Da):68,465
Last modified:December 21, 2004 - v3
Checksum:i51D20BE07765702A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631F → I in AAD04773 (PubMed:9878232).Curated
Sequence conflicti83 – 831N → D in AAD04773 (PubMed:9878232).Curated
Sequence conflicti300 – 3001E → K in AAD04773 (PubMed:9878232).Curated
Sequence conflicti303 – 3031S → A in AAD04773 (PubMed:9878232).Curated
Sequence conflicti335 – 3351C → F in AAD04773 (PubMed:9878232).Curated
Sequence conflicti495 – 4951I → T in AAD04773 (PubMed:9878232).Curated
Sequence conflicti508 – 5081T → S in AAD04773 (PubMed:9878232).Curated
Sequence conflicti606 – 6061E → G in AAD04773 (PubMed:9878232).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96639 Genomic DNA. Translation: AAD04773.2.
AY729880 Genomic DNA. Translation: AAU12157.1.
PIRiT11503.
RefSeqiNP_008481.4. NC_002008.4.

Genome annotation databases

GeneIDi804484.
KEGGicfa:804484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96639 Genomic DNA. Translation: AAD04773.2.
AY729880 Genomic DNA. Translation: AAU12157.1.
PIRiT11503.
RefSeqiNP_008481.4. NC_002008.4.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030319.

Proteomic databases

PaxDbiQ9ZZ57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi804484.
KEGGicfa:804484.

Organism-specific databases

CTDi4540.

Phylogenomic databases

eggNOGiKOG4668. Eukaryota.
COG1009. LUCA.
HOGENOMiHOG000100570.
HOVERGENiHBG108343.
InParanoidiQ9ZZ57.
KOiK03883.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_CANLF
AccessioniPrimary (citable) accession number: Q9ZZ57
Secondary accession number(s): Q66QB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.