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Q9ZZ52

- COX1_SQUAC

UniProt

Q9ZZ52 - COX1_SQUAC

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Protein
Cytochrome c oxidase subunit 1
Gene
MT-CO1, COI, COXI, MTCO1
Organism
Squalus acanthias (Spiny dogfish)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi240 – 2401Copper B Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiSqualus acanthias (Spiny dogfish)
Taxonomic identifieri7797 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiSqualimorphiiSqualiformesSqualidaeSqualus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei56 – 7621Helical; Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei338 – 35821Helical; Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Cytochrome c oxidase subunit 1
PRO_0000183421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9ZZ52.
SMRiQ9ZZ52. Positions 3-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZZ52-1 [UniParc]FASTAAdd to Basket

« Hide

MAINRWFFST NHKDIGTLYL IFGAWAGMVG TALSLLIRAE LSQPGTLLGD    50
DQIYNVIVTA HAFVMIFFMV MPVMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
SFWLLPPSLL LLLASAGVEA GAGTGWTVYP PLAGNMAHAG ASVDLAIFSL 150
HLAGISSILA SINFITTIIN MKPPAISQYQ TPLFVWSILV TTILLLLSLP 200
VLAAAITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGMISHVVAY YSGKKEPFGY MGMVWAMMAI GLLGFIVWAH HMFTVGMDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGG SIKWETPLLW ALGFIFLFTV 350
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFIHWFPLF 400
SGYTLHSTWT KTQFLVMFIG VNLTFFPQHF LGLAGMPRRY SDYPDAYALW 450
NTVSSIGSLI SLVAVIMFLF IIWEAFAPSG KVLSVELPHT NVEWLHGCPP 500
PYHTYEEPAF VQVQRTYF 518
Length:518
Mass (Da):57,267
Last modified:May 1, 1999 - v1
Checksum:i4D90C32D7739ECF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18134 Genomic DNA. Translation: CAA77051.1.
PIRiT11536.
RefSeqiNP_008525.1. NC_002012.1.

Genome annotation databases

GeneIDi808385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18134 Genomic DNA. Translation: CAA77051.1 .
PIRi T11536.
RefSeqi NP_008525.1. NC_002012.1.

3D structure databases

ProteinModelPortali Q9ZZ52.
SMRi Q9ZZ52. Positions 3-514.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808385.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic studies of complete mitochondrial DNA molecules place cartilaginous fishes within the tree of bony fishes."
    Rasmussen A.S., Arnason U.
    J. Mol. Evol. 48:118-123(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_SQUAC
AccessioniPrimary (citable) accession number: Q9ZZ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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