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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Squalus acanthias (Spiny dogfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiSqualus acanthias (Spiny dogfish)
Taxonomic identifieri7797 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiSqualimorphiiSqualiformesSqualidaeSqualus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence analysisAdd
BLAST
Transmembranei452 – 47221HelicalSequence analysisAdd
BLAST
Transmembranei492 – 51221HelicalSequence analysisAdd
BLAST
Transmembranei590 – 61021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610NADH-ubiquinone oxidoreductase chain 5PRO_0000118151Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZZ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMIIFNSAF LLIFIILLYP LISSLSPKEL YPNWSSSHVK TAVKTSFFIS
60 70 80 90 100
LIPLFIYLDQ GLESITTNWN WINIGPFDIN MSFKFDMYSI IFTPVALYVT
110 120 130 140 150
WSILEFALWY MHSDPNMNRF FKYLLLFLIS MIILVTANNM FQLFIGWEGV
160 170 180 190 200
GIMSFLLIGW WYSRADANTA ALQAVIYNRV GDIGLILSMA WLAMNLNSWE
210 220 230 240 250
IQQLFILSKD KDLTLPLLGL VLAAAGKSAQ FGLHPWLPSA MEGPTPVSAL
260 270 280 290 300
LHSSTMVVAG IFLLIRLHPL MQDNQLILTT CLCLGALTTL FTAACALTQN
310 320 330 340 350
DIKKIVAFST SSQLGLMMVT IGLNQPQLAF LHICTHAFFK AMLFLCSGSI
360 370 380 390 400
IHSLNDEQDI RKMGGLHKLL PFTSSSLTVG SLALTGMPFL SGFFSKDAII
410 420 430 440 450
ESMNTSHLNA WALILTLIAT SFTAIYSLRL IFFALMEYPR FPPLSPVNEN
460 470 480 490 500
NILVINPIKR LAYGSILAGL IITSNLPPMK TQIMTMTPLL KLSALLVTII
510 520 530 540 550
GLLLALELAS LTNTQLKTTP TLSTHHFSNM LGYFPMVIHR LVPKTNLKWA
560 570 580 590 600
QHISTHLIDL TWSEKIGPKS TLIQQTPLIK LSTQPQQGMI KTYLTLLFLT
610
LTLAVLIIAI
Length:610
Mass (Da):68,082
Last modified:May 1, 1999 - v1
Checksum:i87F87A229FBA2CBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18134 Genomic DNA. Translation: CAA77059.1.
PIRiT11544.
RefSeqiNP_008533.1. NC_002012.1.

Genome annotation databases

GeneIDi808380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18134 Genomic DNA. Translation: CAA77059.1.
PIRiT11544.
RefSeqiNP_008533.1. NC_002012.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808380.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_SQUAC
AccessioniPrimary (citable) accession number: Q9ZZ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 16, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.