Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

NADH5

Organism
Corvus frugilegus (Rook)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Electron transport, Respiratory chainSAAS annotation, Transport

Keywords - Ligandi

NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:NADH5Imported
Encoded oniMitochondrionImported
OrganismiCorvus frugilegus (Rook)Imported
Taxonomic identifieri75140 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesCorvoideaCorvidaeCorvus

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei86 – 109HelicalSequence analysisAdd BLAST24
Transmembranei116 – 135HelicalSequence analysisAdd BLAST20
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei173 – 192HelicalSequence analysisAdd BLAST20
Transmembranei212 – 230HelicalSequence analysisAdd BLAST19
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei274 – 295HelicalSequence analysisAdd BLAST22
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei334 – 352HelicalSequence analysisAdd BLAST19
Transmembranei373 – 392HelicalSequence analysisAdd BLAST20
Transmembranei404 – 429HelicalSequence analysisAdd BLAST26
Transmembranei450 – 474HelicalSequence analysisAdd BLAST25
Transmembranei486 – 504HelicalSequence analysisAdd BLAST19
Transmembranei582 – 603HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 123Proton_antipo_NInterPro annotationAdd BLAST56
Domaini136 – 418Proton_antipo_MInterPro annotationAdd BLAST283
Domaini423 – 604NADH5_CInterPro annotationAdd BLAST182

Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZZ28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQMFILNTF MLLTLAVLCT PIIFPMLSDS LKNTPTIITN TVKTSFLISL
60 70 80 90 100
VPMTIYIHSG MDSLTSFWEW KFIMNFKIPV SLTMDFYSLT FFPIALFVSW
110 120 130 140 150
SILQFATWYM ASDPHITKFF TFLLLFLIAM LILIISNNLF LLFIGWEGVG
160 170 180 190 200
IMSFLLISWW HGRAEANTAA LQAVLYNRVG DVGLILCMAW LASTMNTWEI
210 220 230 240 250
QQISSQDQTP TLPLLGLILA AAGKSAQFGL HPWLPAAMEG PTPVSALLHS
260 270 280 290 300
STMVVAGIFL LIRTHPLFHN NPTALSLCLC LGALSTLFAA TCALTQNDIK
310 320 330 340 350
KIIAFSTSSQ LGLMMVTIGL NLPQLAFLHI STHAFFKAML FLCSGSIIHS
360 370 380 390 400
LNGEQDIRKM GGLQKMLPTT TSCLTIGNLA LMGTPFLAGF YSKDQIIESL
410 420 430 440 450
NTSYLNAWAL VLTLLATSFT AVYTIRMTLL VQTGYVRIPP LTPMNENNPA
460 470 480 490 500
VLSSITRLAL GSIVAGFLIT SYIPPATKTP PMTMPLSIKI TALVVTLLGI
510 520 530 540 550
ILALELSKMT QALILPKQNR FSNFSTTLGY FNPLVHRFIS TKLLSGGQNI
560 570 580 590 600
ASHLIDLSWY KLLGPEGLAN LQMMASKTAT TFHTGLIKAY LGSFALSIFI

ILLSTY
Length:606
Mass (Da):66,640
Last modified:May 1, 1999 - v1
Checksum:i75586E3648ECB5B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18522 Genomic DNA. Translation: CAA77205.1.
PIRiT11334.
RefSeqiNP_008546.1. NC_002069.2.

Genome annotation databases

GeneIDi808397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18522 Genomic DNA. Translation: CAA77205.1.
PIRiT11334.
RefSeqiNP_008546.1. NC_002069.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808397.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ZZ28_CORFR
AccessioniPrimary (citable) accession number: Q9ZZ28
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.