Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ZZ08

- COX1_HAPMA

UniProt

Q9ZZ08 - COX1_HAPMA

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Hapalochlaena maculosa (Blue-ringed octopus) (Octopus maculosus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi45 – 451Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiHapalochlaena maculosa (Blue-ringed octopus) (Octopus maculosus)
    Taxonomic identifieri61716 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaOctopodiformesOctopodaIncirrataOctopodidaeHapalochlaena

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›219›219Cytochrome c oxidase subunit 1PRO_0000183342Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZZ08.
    SMRiQ9ZZ08. Positions 1-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini‹1 – 1›1Mitochondrial matrixSequence Analysis
    Topological domaini23 – 3917Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini61 – 8525Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini107 – 12822Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini150 – 16617Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini188 – 21932Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei40 – 6021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721Helical; Name=5Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9ZZ08-1 [UniParc]FASTAAdd to Basket

    « Hide

    TLYFIFGIWS GLLGTSLSLM IRTELGQPGS LLNDDQLYNV IVTAHAFVMI    50
    FFLVMPVMIG GFGNWLVPLM LGAPDMAFPR MNNMSFWLLP PSLTLLLSSA 100
    PVESGAGTGW TVYPPLSSNL AHMGPSVDLA IFSLHLAGIS SIPGAINFIT 150
    TIINMRWEGM MMERLPLFVW SVFITAILLL LSLPVLAGAI TMLLTDRNFN 200
    TTFFDPSGGG DPILYQHLF 219
    Length:219
    Mass (Da):23,945
    Last modified:May 1, 1999 - v1
    Checksum:i0D9D1CF45F2584D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei219 – 2191

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000043 Genomic DNA. Translation: AAC95088.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000043 Genomic DNA. Translation: AAC95088.1 .

    3D structure databases

    ProteinModelPortali Q9ZZ08.
    SMRi Q9ZZ08. Positions 1-219.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods."
      Carlini D.B., Graves J.E.
      Bull. Mar. Sci. 64:57-76(1999)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_HAPMA
    AccessioniPrimary (citable) accession number: Q9ZZ08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3