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Q9ZZ08 (COX1_HAPMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismHapalochlaena maculosa (Blue-ringed octopus) (Octopus maculosus)
Taxonomic identifier61716 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaOctopodiformesOctopodaIncirrataOctopodidaeHapalochlaena

Protein attributes

Sequence length219 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›219›219Cytochrome c oxidase subunit 1
PRO_0000183342

Regions

Topological domain‹1›1Mitochondrial matrix Potential
Transmembrane2 – 2221Helical; Name=1; Potential
Topological domain23 – 3917Mitochondrial intermembrane Potential
Transmembrane40 – 6021Helical; Name=2; Potential
Topological domain61 – 8525Mitochondrial matrix Potential
Transmembrane86 – 10621Helical; Name=3; Potential
Topological domain107 – 12822Mitochondrial intermembrane Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 16617Mitochondrial matrix Potential
Transmembrane167 – 18721Helical; Name=5; Potential
Topological domain188 – 21932Mitochondrial intermembrane Potential

Sites

Metal binding451Iron (heme A axial ligand) Probable

Experimental info

Non-terminal residue11
Non-terminal residue2191

Sequences

Sequence LengthMass (Da)Tools
Q9ZZ08 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 0D9D1CF45F2584D9

FASTA21923,945
        10         20         30         40         50         60 
TLYFIFGIWS GLLGTSLSLM IRTELGQPGS LLNDDQLYNV IVTAHAFVMI FFLVMPVMIG 

        70         80         90        100        110        120 
GFGNWLVPLM LGAPDMAFPR MNNMSFWLLP PSLTLLLSSA PVESGAGTGW TVYPPLSSNL 

       130        140        150        160        170        180 
AHMGPSVDLA IFSLHLAGIS SIPGAINFIT TIINMRWEGM MMERLPLFVW SVFITAILLL 

       190        200        210 
LSLPVLAGAI TMLLTDRNFN TTFFDPSGGG DPILYQHLF 

« Hide

References

[1]"Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods."
Carlini D.B., Graves J.E.
Bull. Mar. Sci. 64:57-76(1999)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000043 Genomic DNA. Translation: AAC95088.1.

3D structure databases

ProteinModelPortalQ9ZZ08.
SMRQ9ZZ08. Positions 1-219.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_HAPMA
AccessionPrimary (citable) accession number: Q9ZZ08
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways