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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:ND5
Encoded oniMitochondrion
OrganismiRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifieri34632 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence analysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552NADH-ubiquinone oxidoreductase chain 5PRO_0000118142Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZYM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFINWTMMLI SFSIVFLYMF FMTFYFNIFF IFEYNLMSIL SFEYKFYILL
60 70 80 90 100
DWMSCMFSFT VLMISSMVLW YSHSYMSSDK NKTSFCWMVL MFILSMLLLV
110 120 130 140 150
LMPNVFMLIL GWDGLGLTSY CLVIFYQSSN SYNSGMMTII SNRVGDVMVI
160 170 180 190 200
MMIIFAINFN SFELTSIKSF ELIWGLLIII AGLTKSAQIP FSAWLPAAMA
210 220 230 240 250
APTPVSALVH SSTLVTAGVY LLIRFDLLFN NNIFSAFLMK ISLMTMIMSG
260 270 280 290 300
MNAFFENDLK KIIAFSTLSQ LSIMMLTLSL SLTNLSFFHL IVHAIFKSML
310 320 330 340 350
FLCAGFVIHN LMGNQDIRFL SDFFKFSPLI LSCMMIGMFS LMGFPFIGGF
360 370 380 390 400
YSKDVIMEFF FLKSNNMIEM NMFIVGIIFT FLYNFRLFYM LLLKGTLFNM
410 420 430 440 450
MSKDSINIFM NYPIFNLTVY LLITSNLMSW LLLPEYTMIF LSFTQKLMLL
460 470 480 490 500
FLVPFCTFMF MILLKFIKFF PYLKLNFLMT MWNLSELTSF IMLSNNKFLL
510 520 530 540 550
KMSINDWTWL EMYGPLGIKS KIEHNYNFSM TKEINVITIA FSLTILMMII

VY
Length:552
Mass (Da):64,542
Last modified:May 1, 1999 - v1
Checksum:i583A74F293F4DEEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081829 Genomic DNA. Translation: AAD05525.1.
PIRiT11161.
RefSeqiNP_008518.1. NC_002074.1.

Genome annotation databases

GeneIDi808362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081829 Genomic DNA. Translation: AAD05525.1.
PIRiT11161.
RefSeqiNP_008518.1. NC_002074.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808362.

Organism-specific databases

CTDi4540.

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_RHISA
AccessioniPrimary (citable) accession number: Q9ZYM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 16, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.