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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Papilio xuthus (Asian swallowtail butterfly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation
Gene namesi
Name:COIIImported
Synonyms:COX2Imported
Encoded oniMitochondrionImported
OrganismiPapilio xuthus (Asian swallowtail butterfly)Imported
Taxonomic identifieri66420 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaPapilionidaePapilioninaePapilio

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4324HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8725HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

SMRiQ9ZYK3. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191COX2_TMInterPro annotationAdd
BLAST
Domaini92 – 225134COX2_CUAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATWSNFNLQ NSASPLMEQI IFFHDHTLII LIMITILVGY LMINLFFNKY
60 70 80 90 100
INRFLLEGQM IELIWTIIPT ITLIFIALPS LRLLYLLDEL NNPLITLKSI
110 120 130 140 150
GHQWYWSYEY SDFNNVEFDS YMINYDKSNI NNFRLLDVDN RIILPMNNQI
160 170 180 190 200
RIMVTATDVI HSWTIPSLGV KIDANPGRLN QTNLFINRPG IFFGQCSEIC
210 220
GANHSFMPIM IESISIKNFI NWINNYS
Length:227
Mass (Da):26,555
Last modified:May 1, 1999 - v1
Checksum:i3906BDBFC6500931
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043999 Genomic DNA. Translation: AAD15667.1.
EF621724 Genomic DNA. Translation: ABQ63451.1.
KT922004 Genomic DNA. Translation: ALT55627.1.
RefSeqiYP_009229546.1. NC_029244.1.

Genome annotation databases

GeneIDi26836885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043999 Genomic DNA. Translation: AAD15667.1.
EF621724 Genomic DNA. Translation: ABQ63451.1.
KT922004 Genomic DNA. Translation: ALT55627.1.
RefSeqiYP_009229546.1. NC_029244.1.

3D structure databases

SMRiQ9ZYK3. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26836885.

Organism-specific databases

CTDi4513.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ZYK3_PAPXU
AccessioniPrimary (citable) accession number: Q9ZYK3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.