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Protein

Cytochrome c oxidase subunit 2

Gene

COX-II

Organism
Amblyraja radiata (Thorny skate) (Raja radiata)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotationSAAS annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation
Gene namesi
Name:COX-IIImported
Encoded oniMitochondrionImported
OrganismiAmblyraja radiata (Thorny skate) (Raja radiata)Imported
Taxonomic identifieri386614 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaRajiformesRajidaeAmblyraja

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 5125HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8523HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9ZY42.
SMRiQ9ZY42. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191COX2_TMInterPro annotationAdd
BLAST
Domaini92 – 225134COX2_CUAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZY42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPAQLGFQ DAASPIMEEL LHFHDHTLMI VFLISTLVLY IIVAMVTTKL
60 70 80 90 100
TNKYILDSQE IEIVWTILPA IILIMIALPS LRILYLMDEI NDPHITIKAL
110 120 130 140 150
GHQWYWSYEY TDYENLEFDS YMIQTEDLYP GQFRLLETDH RMVVPMESPI
160 170 180 190 200
RVLVTAEDVL HSWTIPALGV KMDAVPGRLN QTAFIISRPG VYYGQCSEIC
210 220 230
GANHSFMPIV VEAVPLEHFE NWSSLMLEEV
Length:230
Mass (Da):26,440
Last modified:May 1, 1999 - v1
Checksum:i9D500DA155030D50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106038 Genomic DNA. Translation: AAD19932.1.
PIRiT11290.
RefSeqiNP_008059.1. NC_000893.1.

Genome annotation databases

GeneIDi808715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106038 Genomic DNA. Translation: AAD19932.1.
PIRiT11290.
RefSeqiNP_008059.1. NC_000893.1.

3D structure databases

ProteinModelPortaliQ9ZY42.
SMRiQ9ZY42. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808715.

Organism-specific databases

CTDi4513.

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Rasmussen A.-S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. "Molecular studies suggest that cartilaginous fishes have a terminal position in the piscine tree."
    Rasmussen A.S., Arnason U.
    Proc. Natl. Acad. Sci. U.S.A. 96:2177-2182(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ9ZY42_AMBRA
AccessioniPrimary (citable) accession number: Q9ZY42
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.