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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Gracilariopsis lemaneiformis (Red alga) (Gracilaria lemaneiformis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiGracilariopsis lemaneiformis (Red alga) (Gracilaria lemaneiformis)Imported
Taxonomic identifieri2782 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeGracilarialesGracilariaceaeGracilariopsis

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9ZY18.
SMRiQ9ZY18. Positions 8-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 527522COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZY18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFSFNQWVS RWIFSTNHKD IGTLYLIFGA FSGVLGGCMS MLIRMELAQP
60 70 80 90 100
GNQFLLGNHQ IYNVLITAHA FLMIFFMVMP VMIGGFGNWL VPIMIGSPDM
110 120 130 140 150
AFPRLNNISF WLLPPSLCLL LASAIVEVGV GTGWTVYPPL SSIQSHSGGA
160 170 180 190 200
VDLAIFSLHI SGASSILGAI NFISTILNMR NPGQSMYRMP LFVWSIFITA
210 220 230 240 250
FLLLLAVPVL AGAITMLLTD RNFNTTFFDP AGGGDPVLYQ HLFWFFGHPE
260 270 280 290 300
VYILILPGFG MVSHIVSTFS RKPVFGYIGM VYAMVSIGVL GFIVWAHHMY
310 320 330 340 350
TVGLDVDTRA YFTAATMIIA VPTGIKIFSW IATMWEGSIH FKTPMLFATG
360 370 380 390 400
FIFLFTIGGL TGIVLANSGL DISLHDTYYV VAHFHYVLSM GAVFAIFAGF
410 420 430 440 450
YYWFGKITGV QYPELLGQIH FWSTFIGVNL TFMPMHFLGL AGMPRRIPDY
460 470 480 490 500
PDAYAGWNLV ASYGSYMALF STLFFFYLVF VSLTSKNPCV SAPWNFEQSI
510 520 530
TKGNSTLEWV VTSPPAYHTF EEMPLICETV K
Length:531
Mass (Da):59,067
Last modified:May 1, 1999 - v1
Checksum:i4C0E66950DE377B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118119 Genomic DNA. Translation: AAD17226.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118119 Genomic DNA. Translation: AAD17226.1.

3D structure databases

ProteinModelPortaliQ9ZY18.
SMRiQ9ZY18. Positions 8-522.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Lang F.B.F., Goff L.J.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9ZY18_GRALE
AccessioniPrimary (citable) accession number: Q9ZY18
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.