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Q9ZWM9

- RAV1_ARATH

UniProt

Q9ZWM9 - RAV1_ARATH

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Protein
AP2/ERF and B3 domain-containing transcription factor RAV1
Gene
RAV1, At1g13260, T6J4.2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds specifically to bipartite recognition sequences composed of two unrelated motifs, 5'-CAACA-3' and 5'-CACCTG-3'. May function as negative regulator of plant growth and development.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi61 – 11656AP2/ERF
Add
BLAST
DNA bindingi188 – 292105TF-B3
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: TAIR
  2. sequence-specific DNA binding transcription factor activity Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. ethylene-activated signaling pathway Source: UniProtKB-KW
  2. lateral root development Source: TAIR
  3. leaf development Source: TAIR
  4. negative regulation of flower development Source: TAIR
  5. negative regulation of transcription, DNA-templated Source: TAIR
  6. response to brassinosteroid Source: TAIR
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ethylene signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AP2/ERF and B3 domain-containing transcription factor RAV1
Alternative name(s):
Ethylene-responsive transcription factor RAV1
Protein RELATED TO ABI3/VP1 1
Gene namesi
Name:RAV1
Ordered Locus Names:At1g13260
ORF Names:T6J4.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G13260.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344AP2/ERF and B3 domain-containing transcription factor RAV1
PRO_0000112571Add
BLAST

Proteomic databases

PRIDEiQ9ZWM9.

Expressioni

Tissue specificityi

Expressed in all tissues examined: Roots, rosette leaves, cauline leaves, inflorescence stems, flowers and siliques. Highest expression in roots and rosette leaves. Very low expression in flowers.1 Publication

Inductioni

Down-regulated by brassinosteroid and zeatin.1 Publication

Gene expression databases

GenevestigatoriQ9ZWM9.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi23126. 5 interactions.
STRINGi3702.AT1G13260.1-P.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi185 – 1917
Turni194 – 1974
Beta strandi198 – 2003
Beta strandi203 – 2053
Helixi207 – 2104
Turni211 – 2133
Beta strandi226 – 2327
Turni233 – 2353
Beta strandi236 – 24510
Turni246 – 2494
Beta strandi250 – 2567
Helixi257 – 2637
Beta strandi271 – 2766
Beta strandi279 – 2813
Beta strandi284 – 2896

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WIDNMR-A182-298[»]
ProteinModelPortaliQ9ZWM9.
SMRiQ9ZWM9. Positions 62-115, 182-298.

Miscellaneous databases

EvolutionaryTraceiQ9ZWM9.

Family & Domainsi

Domaini

Contains two distinct DNA-binding domains. One is located in the N-terminal region and binds to the 5'-CAACA-3' motif. The second is located in the C-terminal region and binds to the 5'-CACCTG-3' motif.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG266118.
HOGENOMiHOG000237484.
InParanoidiQ9ZWM9.
KOiK09287.
OMAiICETPAI.
PhylomeDBiQ9ZWM9.

Family and domain databases

Gene3Di2.40.330.10. 1 hit.
3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR003340. B3_DNA-bd.
IPR016177. DNA-bd_dom.
IPR015300. DNA-bd_pseudobarrel.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
PF02362. B3. 1 hit.
[Graphical view]
SMARTiSM00380. AP2. 1 hit.
SM01019. B3. 1 hit.
[Graphical view]
SUPFAMiSSF101936. SSF101936. 1 hit.
SSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
PS50863. B3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZWM9-1 [UniParc]FASTAAdd to Basket

« Hide

MESSSVDEST TSTGSICETP AITPAKKSSV GNLYRMGSGS SVVLDSENGV    50
EAESRKLPSS KYKGVVPQPN GRWGAQIYEK HQRVWLGTFN EEDEAARAYD 100
VAVHRFRRRD AVTNFKDVKM DEDEVDFLNS HSKSEIVDML RKHTYNEELE 150
QSKRRRNGNG NMTRTLLTSG LSNDGVSTTG FRSAEALFEK AVTPSDVGKL 200
NRLVIPKHHA EKHFPLPSSN VSVKGVLLNF EDVNGKVWRF RYSYWNSSQS 250
YVLTKGWSRF VKEKNLRAGD VVSFSRSNGQ DQQLYIGWKS RSGSDLDAGR 300
VLRLFGVNIS PESSRNDVVG NKRVNDTEML SLVCSKKQRI FHAS 344
Length:344
Mass (Da):38,597
Last modified:May 1, 1999 - v1
Checksum:i7349B640B3505823
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013886 mRNA. Translation: BAA34250.1.
AC011810 Genomic DNA. Translation: AAG09554.1.
CP002684 Genomic DNA. Translation: AEE28991.1.
AY063855 mRNA. Translation: AAL36211.1.
AY091291 mRNA. Translation: AAM14230.1.
PIRiT51329.
RefSeqiNP_172784.1. NM_101197.3.
UniGeneiAt.20558.

Genome annotation databases

EnsemblPlantsiAT1G13260.1; AT1G13260.1; AT1G13260.
GeneIDi837886.
KEGGiath:AT1G13260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013886 mRNA. Translation: BAA34250.1 .
AC011810 Genomic DNA. Translation: AAG09554.1 .
CP002684 Genomic DNA. Translation: AEE28991.1 .
AY063855 mRNA. Translation: AAL36211.1 .
AY091291 mRNA. Translation: AAM14230.1 .
PIRi T51329.
RefSeqi NP_172784.1. NM_101197.3.
UniGenei At.20558.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WID NMR - A 182-298 [» ]
ProteinModelPortali Q9ZWM9.
SMRi Q9ZWM9. Positions 62-115, 182-298.
ModBasei Search...

Protein-protein interaction databases

BioGridi 23126. 5 interactions.
STRINGi 3702.AT1G13260.1-P.

Proteomic databases

PRIDEi Q9ZWM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G13260.1 ; AT1G13260.1 ; AT1G13260 .
GeneIDi 837886.
KEGGi ath:AT1G13260.

Organism-specific databases

TAIRi AT1G13260.

Phylogenomic databases

eggNOGi NOG266118.
HOGENOMi HOG000237484.
InParanoidi Q9ZWM9.
KOi K09287.
OMAi ICETPAI.
PhylomeDBi Q9ZWM9.

Miscellaneous databases

EvolutionaryTracei Q9ZWM9.

Gene expression databases

Genevestigatori Q9ZWM9.

Family and domain databases

Gene3Di 2.40.330.10. 1 hit.
3.30.730.10. 1 hit.
InterProi IPR001471. AP2/ERF_dom.
IPR003340. B3_DNA-bd.
IPR016177. DNA-bd_dom.
IPR015300. DNA-bd_pseudobarrel.
[Graphical view ]
Pfami PF00847. AP2. 1 hit.
PF02362. B3. 1 hit.
[Graphical view ]
SMARTi SM00380. AP2. 1 hit.
SM01019. B3. 1 hit.
[Graphical view ]
SUPFAMi SSF101936. SSF101936. 1 hit.
SSF54171. SSF54171. 1 hit.
PROSITEi PS51032. AP2_ERF. 1 hit.
PS50863. B3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plants."
    Kagaya Y., Ohmiya K., Hattori T.
    Nucleic Acids Res. 27:470-478(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: cv. Columbia.
    Tissue: Seedling.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. Cited for: GENE FAMILY.
  6. "Solution structure of the B3 DNA binding domain of the Arabidopsis cold-responsive transcription factor RAV1."
    Yamasaki K., Kigawa T., Inoue M., Tateno M., Yamasaki T., Yabuki T., Aoki M., Seki E., Matsuda T., Tomo Y., Hayami N., Terada T., Shirouzu M., Osanai T., Tanaka A., Seki M., Shinozaki K., Yokoyama S.
    Plant Cell 16:3448-3459(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 182-298.
  7. "Genome-wide analysis of the ERF gene family in Arabidopsis and rice."
    Nakano T., Suzuki K., Fujimura T., Shinshi H.
    Plant Physiol. 140:411-432(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  8. "Arabidopsis RAV1 is down-regulated by brassinosteroid and may act as a negative regulator during plant development."
    Hu Y.X., Wang Y.H., Liu X.F., Li J.Y.
    Cell Res. 14:8-15(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiRAV1_ARATH
AccessioniPrimary (citable) accession number: Q9ZWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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