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Q9ZWA6

- MGP_ARATH

UniProt

Q9ZWA6 - MGP_ARATH

Protein

Zinc finger protein MAGPIE

Gene

MGP

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Probable transcription factor that regulates tissue boundaries and asymmetric cell division. Might be involved in the sequestration of 'SHORT-ROOT' to the nucleus.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 9223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16924C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: TAIR

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: TAIR
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein MAGPIE
    Gene namesi
    Name:MGP
    Ordered Locus Names:At1g03840
    ORF Names:F11M21.23
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G03840.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Zinc finger protein MAGPIEPRO_0000337841Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZWA6.

    Expressioni

    Tissue specificityi

    Expressed in the ground tissue and stele cells of embryos and 2-days post-germination roots but not in the quiescent center. Detected only in cells that perform asymmetric cell divisions.1 Publication

    Gene expression databases

    ArrayExpressiQ9ZWA6.
    GenevestigatoriQ9ZWA6.

    Interactioni

    Subunit structurei

    Interacts with SHR, SCR and JKD, but not with itself.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    JKDQ700D23EBI-1568600,EBI-1568562
    SCRQ9M3843EBI-1568600,EBI-1250484

    Protein-protein interaction databases

    IntActiQ9ZWA6. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZWA6.
    SMRiQ9ZWA6. Positions 60-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi23 – 3210His-rich
    Compositional biasi232 – 24918Pro-richAdd
    BLAST
    Compositional biasi251 – 2555Poly-His
    Compositional biasi440 – 4434Poly-Asn
    Compositional biasi480 – 4834Poly-Gly

    Sequence similaritiesi

    Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 9223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16924C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG246610.
    HOGENOMiHOG000237608.
    InParanoidiQ9ZWA6.
    OMAiNQIVEDG.
    PhylomeDBiQ9ZWA6.

    Family and domain databases

    Gene3Di3.30.160.60. 1 hit.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ZWA6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTEDQTISS SGGYVQSSST TDHVDHHHHD QHESLNPPLV KKKRNLPGNP    50
    DPEAEVIALS PKTLMATNRF LCEICGKGFQ RDQNLQLHRR GHNLPWKLKQ 100
    RTSKEVRKRV YVCPEKSCVH HHPTRALGDL TGIKKHFCRK HGEKKWKCEK 150
    CAKRYAVQSD WKAHSKTCGT REYRCDCGTI FSRRDSFITH RAFCDALAEE 200
    TARLNAASHL KSFAATAGSN LNYHYLMGTL IPSPSLPQPP SFPFGPPQPQ 250
    HHHHHQFPIT TNNFDHQDVM KPASTLSLWS GGNINHHQQV TIEDRMAPQP 300
    HSPQEDYNWV FGNANNHGEL ITTSDSLITH DNNINIVQSK ENANGATSLS 350
    VPSLFSSVDQ ITQDANAASV AVANMSATAL LQKAAQMGAT SSTSPTTTIT 400
    TDQSAYLQSF ASKSNQIVED GGSDRFFASF GSNSVELMSN NNNGLHEIGN 450
    PRNGVTVVSG MGELQNYPWK RRRVDIGNAG GGGQTRDFLG VGVQTICHSS 500
    SINGWI 506
    Length:506
    Mass (Da):55,826
    Last modified:May 1, 1999 - v1
    Checksum:iC27006B44C77D1C7
    GO
    Isoform 2 (identifier: Q9ZWA6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         50-51: Missing.

    Note: May be due to a competing acceptor splice site.

    Show »
    Length:504
    Mass (Da):55,614
    Checksum:iE4757C11E865D056
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei50 – 512Missing in isoform 2. 1 PublicationVSP_036332

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY568648 mRNA. Translation: AAS79538.1.
    AJ630476 mRNA. Translation: CAG25849.1.
    AC003027 Genomic DNA. Translation: AAD10684.1.
    CP002684 Genomic DNA. Translation: AEE27620.1.
    CP002684 Genomic DNA. Translation: AEE27621.1.
    BT006209 mRNA. Translation: AAP12858.1.
    AK227837 mRNA. Translation: BAE99815.1.
    PIRiA86169.
    RefSeqiNP_001030951.1. NM_001035874.1. [Q9ZWA6-2]
    NP_171880.1. NM_100263.3. [Q9ZWA6-1]
    UniGeneiAt.42516.

    Genome annotation databases

    EnsemblPlantsiAT1G03840.1; AT1G03840.1; AT1G03840. [Q9ZWA6-1]
    GeneIDi839396.
    KEGGiath:AT1G03840.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY568648 mRNA. Translation: AAS79538.1 .
    AJ630476 mRNA. Translation: CAG25849.1 .
    AC003027 Genomic DNA. Translation: AAD10684.1 .
    CP002684 Genomic DNA. Translation: AEE27620.1 .
    CP002684 Genomic DNA. Translation: AEE27621.1 .
    BT006209 mRNA. Translation: AAP12858.1 .
    AK227837 mRNA. Translation: BAE99815.1 .
    PIRi A86169.
    RefSeqi NP_001030951.1. NM_001035874.1. [Q9ZWA6-2 ]
    NP_171880.1. NM_100263.3. [Q9ZWA6-1 ]
    UniGenei At.42516.

    3D structure databases

    ProteinModelPortali Q9ZWA6.
    SMRi Q9ZWA6. Positions 60-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ZWA6. 3 interactions.

    Proteomic databases

    PRIDEi Q9ZWA6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G03840.1 ; AT1G03840.1 ; AT1G03840 . [Q9ZWA6-1 ]
    GeneIDi 839396.
    KEGGi ath:AT1G03840.

    Organism-specific databases

    TAIRi AT1G03840.

    Phylogenomic databases

    eggNOGi NOG246610.
    HOGENOMi HOG000237608.
    InParanoidi Q9ZWA6.
    OMAi NQIVEDG.
    PhylomeDBi Q9ZWA6.

    Gene expression databases

    ArrayExpressi Q9ZWA6.
    Genevestigatori Q9ZWA6.

    Family and domain databases

    Gene3Di 3.30.160.60. 1 hit.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    6. Cited for: INDUCTION BY SHR.
    7. "Arabidopsis JACKDAW and MAGPIE zinc finger proteins delimit asymmetric cell division and stabilize tissue boundaries by restricting SHORT-ROOT action."
      Welch D., Hassan H., Blilou I., Immink R., Heidstra R., Scheres B.
      Genes Dev. 21:2196-2204(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH SHR; SCR AND JKD.

    Entry informationi

    Entry nameiMGP_ARATH
    AccessioniPrimary (citable) accession number: Q9ZWA6
    Secondary accession number(s): Q700E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    MGP expression is SHR- and SCR-dependent.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3