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Protein

Glutathione S-transferase U1

Gene

GSTU1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT2G29490-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U1 (EC:2.5.1.18)
Short name:
AtGSTU1
Alternative name(s):
GST class-tau member 1
Glutathione S-transferase 19
Gene namesi
Name:GSTU1
Synonyms:GST19
Ordered Locus Names:At2g29490
ORF Names:F16P2.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29490
TAIRilocus:2042987 AT2G29490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135481 – 224Glutathione S-transferase U1Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZW30

Expressioni

Inductioni

By acetochlor, metolachlor and 2,4,6-trinitrotoluene (TNT).1 Publication

Gene expression databases

ExpressionAtlasiQ9ZW30 baseline and differential
GenevisibleiQ9ZW30 AT

Interactioni

Protein-protein interaction databases

BioGridi2848, 6 interactors
IntActiQ9ZW30, 6 interactors
STRINGi3702.AT2G29490.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZW30
SMRiQ9ZW30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 85GST N-terminalAdd BLAST80
Domaini90 – 217GST C-terminalAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 17Glutathione bindingBy similarity2
Regioni42 – 43Glutathione bindingBy similarity2
Regioni56 – 57Glutathione bindingBy similarity2
Regioni69 – 70Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
HOGENOMiHOG000125749
InParanoidiQ9ZW30
KOiK00799
OMAiDMIAGSM
OrthoDBiEOG09360KSR
PhylomeDBiQ9ZW30

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZW30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEESVKL LGFWASPFSR RVEMALKLKG VPYEYLEEDL PNKTPLLLEL
60 70 80 90 100
NPLHKKVPVL VHNDKILLES HLILEYIDQT WKNSPILPQD PYEKAMARFW
110 120 130 140 150
AKFIDDQILT LGFRSLVKAE KGREVAIEET RELLMFLEKE VTGKDFFGGK
160 170 180 190 200
TIGFLDMIAG SMIPFCLARL WKGIGIDMIP EEKFPELNRW IKNLEEVEAV
210 220
RGCIPPREKQ IERMTKIAET IKSA
Length:224
Mass (Da):25,914
Last modified:May 1, 1999 - v1
Checksum:i5BD722371683FED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288183 mRNA Translation: AAG30132.1
AC004561 Genomic DNA Translation: AAC95189.1
CP002685 Genomic DNA Translation: AEC08260.1
AF428387 mRNA Translation: AAL16155.1
BT010162 mRNA Translation: AAQ22631.1
PIRiA84697
RefSeqiNP_180510.1, NM_128503.3
UniGeneiAt.20874

Genome annotation databases

EnsemblPlantsiAT2G29490.1; AT2G29490.1; AT2G29490
GeneIDi817498
GrameneiAT2G29490.1; AT2G29490.1; AT2G29490
KEGGiath:AT2G29490

Similar proteinsi

Entry informationi

Entry nameiGSTU1_ARATH
AccessioniPrimary (citable) accession number: Q9ZW30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health