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Protein

Glutathione S-transferase U1

Gene

GSTU1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • response to toxic substance Source: UniProtKB-KW
  • toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT2G29490-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U1 (EC:2.5.1.18)
Short name:
AtGSTU1
Alternative name(s):
GST class-tau member 1
Glutathione S-transferase 19
Gene namesi
Name:GSTU1
Synonyms:GST19
Ordered Locus Names:At2g29490
ORF Names:F16P2.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G29490.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Glutathione S-transferase U1PRO_0000413548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZW30.
PRIDEiQ9ZW30.

Expressioni

Inductioni

By acetochlor, metolachlor and 2,4,6-trinitrotoluene (TNT).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi2848. 6 interactions.
IntActiQ9ZW30. 6 interactions.
STRINGi3702.AT2G29490.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZW30.
SMRiQ9ZW30. Positions 6-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8580GST N-terminalAdd
BLAST
Domaini90 – 217128GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 172Glutathione bindingBy similarity
Regioni42 – 432Glutathione bindingBy similarity
Regioni56 – 572Glutathione bindingBy similarity
Regioni69 – 702Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125749.
InParanoidiQ9ZW30.
KOiK00799.
OMAiDMIAGSM.
PhylomeDBiQ9ZW30.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZW30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEESVKL LGFWASPFSR RVEMALKLKG VPYEYLEEDL PNKTPLLLEL
60 70 80 90 100
NPLHKKVPVL VHNDKILLES HLILEYIDQT WKNSPILPQD PYEKAMARFW
110 120 130 140 150
AKFIDDQILT LGFRSLVKAE KGREVAIEET RELLMFLEKE VTGKDFFGGK
160 170 180 190 200
TIGFLDMIAG SMIPFCLARL WKGIGIDMIP EEKFPELNRW IKNLEEVEAV
210 220
RGCIPPREKQ IERMTKIAET IKSA
Length:224
Mass (Da):25,914
Last modified:May 1, 1999 - v1
Checksum:i5BD722371683FED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288183 mRNA. Translation: AAG30132.1.
AC004561 Genomic DNA. Translation: AAC95189.1.
CP002685 Genomic DNA. Translation: AEC08260.1.
AF428387 mRNA. Translation: AAL16155.1.
BT010162 mRNA. Translation: AAQ22631.1.
PIRiA84697.
RefSeqiNP_180510.1. NM_128503.2.
UniGeneiAt.20874.

Genome annotation databases

EnsemblPlantsiAT2G29490.1; AT2G29490.1; AT2G29490.
GeneIDi817498.
KEGGiath:AT2G29490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288183 mRNA. Translation: AAG30132.1.
AC004561 Genomic DNA. Translation: AAC95189.1.
CP002685 Genomic DNA. Translation: AEC08260.1.
AF428387 mRNA. Translation: AAL16155.1.
BT010162 mRNA. Translation: AAQ22631.1.
PIRiA84697.
RefSeqiNP_180510.1. NM_128503.2.
UniGeneiAt.20874.

3D structure databases

ProteinModelPortaliQ9ZW30.
SMRiQ9ZW30. Positions 6-221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2848. 6 interactions.
IntActiQ9ZW30. 6 interactions.
STRINGi3702.AT2G29490.1.

Proteomic databases

PaxDbiQ9ZW30.
PRIDEiQ9ZW30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G29490.1; AT2G29490.1; AT2G29490.
GeneIDi817498.
KEGGiath:AT2G29490.

Organism-specific databases

TAIRiAT2G29490.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125749.
InParanoidiQ9ZW30.
KOiK00799.
OMAiDMIAGSM.
PhylomeDBiQ9ZW30.

Enzyme and pathway databases

BioCyciARA:AT2G29490-MONOMER.

Miscellaneous databases

PROiQ9ZW30.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Gene expression and microscopic analysis of Arabidopsis exposed to chloroacetanilide herbicides and explosive compounds. A phytoremediation approach."
    Mezzari M.P., Walters K., Jelinkova M., Shih M.C., Just C.L., Schnoor J.L.
    Plant Physiol. 138:858-869(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiGSTU1_ARATH
AccessioniPrimary (citable) accession number: Q9ZW30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.