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Protein

Glutathione S-transferase U3

Gene

GSTU3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • response to toxic substance Source: UniProtKB-KW
  • toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT2G29470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U3 (EC:2.5.1.18)
Short name:
AtGSTU3
Alternative name(s):
GST class-tau member 3
Glutathione S-transferase 21
Gene namesi
Name:GSTU3
Synonyms:GST21
Ordered Locus Names:At2g29470
ORF Names:F16P2.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G29470.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135501 – 225Glutathione S-transferase U3Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZW28.

Expressioni

Gene expression databases

GenevisibleiQ9ZW28. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29470.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZW28.
SMRiQ9ZW28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 86GST N-terminalAdd BLAST81
Domaini91 – 218GST C-terminalAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 17Glutathione bindingBy similarity2
Regioni43 – 44Glutathione bindingBy similarity2
Regioni57 – 58Glutathione bindingBy similarity2
Regioni70 – 71Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9ZW28.
KOiK00799.
OMAiVVGSMIP.
OrthoDBiEOG09360KSR.
PhylomeDBiQ9ZW28.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZW28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEEGVKL IGSWASPFSR RVEMALKLKG VPYDYLDEDY LVVKSPLLLQ
60 70 80 90 100
LNPVYKKVPV LVHNGKILPE SQLILEYIDQ TWTNNPILPQ SPYDKAMARF
110 120 130 140 150
WAKFVDEQVT MIGLRSLVKS EKRIDVAIEE VQELIMLLEN QITGKKLFGG
160 170 180 190 200
ETIGFLDMVV GSMIPFCLAR AWEGMGIDMI PEEKFPELNR WIKNLKEIEI
210 220
VRECIPDREK HIEHMMKIVG RIKAV
Length:225
Mass (Da):25,941
Last modified:May 1, 1999 - v1
Checksum:i612AD3270285CD03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288185 mRNA. Translation: AAG30134.1.
AC004561 Genomic DNA. Translation: AAC95191.1.
CP002685 Genomic DNA. Translation: AEC08258.1.
AK117612 mRNA. Translation: BAC42268.1.
PIRiG84696.
RefSeqiNP_180508.1. NM_128501.4.
UniGeneiAt.12689.

Genome annotation databases

EnsemblPlantsiAT2G29470.1; AT2G29470.1; AT2G29470.
GeneIDi817496.
GrameneiAT2G29470.1; AT2G29470.1; AT2G29470.
KEGGiath:AT2G29470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288185 mRNA. Translation: AAG30134.1.
AC004561 Genomic DNA. Translation: AAC95191.1.
CP002685 Genomic DNA. Translation: AEC08258.1.
AK117612 mRNA. Translation: BAC42268.1.
PIRiG84696.
RefSeqiNP_180508.1. NM_128501.4.
UniGeneiAt.12689.

3D structure databases

ProteinModelPortaliQ9ZW28.
SMRiQ9ZW28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G29470.1.

Proteomic databases

PaxDbiQ9ZW28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G29470.1; AT2G29470.1; AT2G29470.
GeneIDi817496.
GrameneiAT2G29470.1; AT2G29470.1; AT2G29470.
KEGGiath:AT2G29470.

Organism-specific databases

TAIRiAT2G29470.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9ZW28.
KOiK00799.
OMAiVVGSMIP.
OrthoDBiEOG09360KSR.
PhylomeDBiQ9ZW28.

Enzyme and pathway databases

BioCyciARA:AT2G29470-MONOMER.

Miscellaneous databases

PROiQ9ZW28.

Gene expression databases

GenevisibleiQ9ZW28. AT.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTU3_ARATH
AccessioniPrimary (citable) accession number: Q9ZW28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.