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Protein

Glutathione S-transferase U3

Gene

GSTU3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
  2. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT2G29470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U3 (EC:2.5.1.18)
Short name:
AtGSTU3
Alternative name(s):
GST class-tau member 3
Glutathione S-transferase 21
Gene namesi
Name:GSTU3
Synonyms:GST21
Ordered Locus Names:At2g29470
ORF Names:F16P2.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G29470.

Subcellular locationi

Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Glutathione S-transferase U3PRO_0000413550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei152 – 1521PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZW28.
PRIDEiQ9ZW28.

Expressioni

Gene expression databases

GenevestigatoriQ9ZW28.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29470.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZW28.
SMRiQ9ZW28. Positions 6-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8681GST N-terminalAdd
BLAST
Domaini91 – 218128GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 172Glutathione bindingBy similarity
Regioni43 – 442Glutathione bindingBy similarity
Regioni57 – 582Glutathione bindingBy similarity
Regioni70 – 712Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG274516.
HOGENOMiHOG000125749.
InParanoidiQ9ZW28.
KOiK00799.
OMAiICESIII.
PhylomeDBiQ9ZW28.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZW28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEEGVKL IGSWASPFSR RVEMALKLKG VPYDYLDEDY LVVKSPLLLQ
60 70 80 90 100
LNPVYKKVPV LVHNGKILPE SQLILEYIDQ TWTNNPILPQ SPYDKAMARF
110 120 130 140 150
WAKFVDEQVT MIGLRSLVKS EKRIDVAIEE VQELIMLLEN QITGKKLFGG
160 170 180 190 200
ETIGFLDMVV GSMIPFCLAR AWEGMGIDMI PEEKFPELNR WIKNLKEIEI
210 220
VRECIPDREK HIEHMMKIVG RIKAV
Length:225
Mass (Da):25,941
Last modified:May 1, 1999 - v1
Checksum:i612AD3270285CD03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288185 mRNA. Translation: AAG30134.1.
AC004561 Genomic DNA. Translation: AAC95191.1.
CP002685 Genomic DNA. Translation: AEC08258.1.
AK117612 mRNA. Translation: BAC42268.1.
PIRiG84696.
RefSeqiNP_180508.1. NM_128501.3.
UniGeneiAt.12689.

Genome annotation databases

EnsemblPlantsiAT2G29470.1; AT2G29470.1; AT2G29470.
GeneIDi817496.
KEGGiath:AT2G29470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288185 mRNA. Translation: AAG30134.1.
AC004561 Genomic DNA. Translation: AAC95191.1.
CP002685 Genomic DNA. Translation: AEC08258.1.
AK117612 mRNA. Translation: BAC42268.1.
PIRiG84696.
RefSeqiNP_180508.1. NM_128501.3.
UniGeneiAt.12689.

3D structure databases

ProteinModelPortaliQ9ZW28.
SMRiQ9ZW28. Positions 6-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G29470.1-P.

Proteomic databases

PaxDbiQ9ZW28.
PRIDEiQ9ZW28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G29470.1; AT2G29470.1; AT2G29470.
GeneIDi817496.
KEGGiath:AT2G29470.

Organism-specific databases

TAIRiAT2G29470.

Phylogenomic databases

eggNOGiNOG274516.
HOGENOMiHOG000125749.
InParanoidiQ9ZW28.
KOiK00799.
OMAiICESIII.
PhylomeDBiQ9ZW28.

Enzyme and pathway databases

BioCyciARA:AT2G29470-MONOMER.

Gene expression databases

GenevestigatoriQ9ZW28.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiGSTU3_ARATH
AccessioniPrimary (citable) accession number: Q9ZW28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.