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Protein

Glutathione S-transferase U4

Gene

GSTU4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Enzyme and pathway databases

BioCyciARA:AT2G29460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U4 (EC:2.5.1.18)
Short name:
AtGSTU4
Alternative name(s):
GST class-tau member 4
Glutathione S-transferase 22
Gene namesi
Name:GSTU4
Synonyms:GST22
Ordered Locus Names:At2g29460
ORF Names:F16P2.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29460.
TAIRilocus:2043017. AT2G29460.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135511 – 224Glutathione S-transferase U4Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZW27.

PTM databases

iPTMnetiQ9ZW27.

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZW27. baseline and differential.
GenevisibleiQ9ZW27. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29460.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZW27.
SMRiQ9ZW27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 85GST N-terminalAdd BLAST80
Domaini90 – 217GST C-terminalAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 17Glutathione bindingBy similarity2
Regioni42 – 43Glutathione bindingBy similarity2
Regioni56 – 57Glutathione bindingBy similarity2
Regioni69 – 70Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9ZW27.
KOiK00799.
OMAiIPNREKQ.
OrthoDBiEOG09360KSR.
PhylomeDBiQ9ZW27.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZW27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEEDVKL LGFWASPFTR RVEMAFKLKG VPYEYLEQDI VNKSPLLLQI
60 70 80 90 100
NPVYKKVPVL VYKGKILSES HVILEYIDQI WKNNPILPQD PYEKAMALFW
110 120 130 140 150
AKFVDEQVGP VAFMSVAKAE KGVEVAIKEA QELFMFLEKE VTGKDFFGGK
160 170 180 190 200
TIGFLDLVAG SMIPFCLARG WEGMGIDMIP EEKFPELNRW IKNLKEIEIV
210 220
RECIPPREEQ IEHMKKVVER IKSA
Length:224
Mass (Da):25,839
Last modified:May 1, 1999 - v1
Checksum:i3810B34656614BE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173G → D in AAK62449 (PubMed:14593172).Curated1
Sequence conflicti173G → D in AAO30062 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288186 mRNA. Translation: AAG30135.1.
AC004561 Genomic DNA. Translation: AAC95192.1.
CP002685 Genomic DNA. Translation: AEC08257.1.
AF387004 mRNA. Translation: AAK62449.1.
BT003399 mRNA. Translation: AAO30062.1.
PIRiF84696.
RefSeqiNP_180507.1. NM_128500.4.
UniGeneiAt.12688.
At.67637.
At.68148.

Genome annotation databases

EnsemblPlantsiAT2G29460.1; AT2G29460.1; AT2G29460.
GeneIDi817495.
GrameneiAT2G29460.1; AT2G29460.1; AT2G29460.
KEGGiath:AT2G29460.

Similar proteinsi

Entry informationi

Entry nameiGSTU4_ARATH
AccessioniPrimary (citable) accession number: Q9ZW27
Secondary accession number(s): Q94EZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome