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Q9ZW27

- GSTU4_ARATH

UniProt

Q9ZW27 - GSTU4_ARATH

Protein

Glutathione S-transferase U4

Gene

GSTU4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW
    2. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification

    Enzyme and pathway databases

    BioCyciARA:AT2G29460-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase U4 (EC:2.5.1.18)
    Short name:
    AtGSTU4
    Alternative name(s):
    GST class-tau member 4
    Glutathione S-transferase 22
    Gene namesi
    Name:GSTU4
    Synonyms:GST22
    Ordered Locus Names:At2g29460
    ORF Names:F16P2.16
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G29460.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Glutathione S-transferase U4PRO_0000413551Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9ZW27.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ZW27.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G29460.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZW27.
    SMRiQ9ZW27. Positions 6-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 8580GST N-terminalAdd
    BLAST
    Domaini90 – 217128GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni16 – 172Glutathione bindingBy similarity
    Regioni42 – 432Glutathione bindingBy similarity
    Regioni56 – 572Glutathione bindingBy similarity
    Regioni69 – 702Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Tau family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG288793.
    HOGENOMiHOG000125749.
    InParanoidiQ9ZW27.
    KOiK00799.
    OMAiEYLEQDI.
    PhylomeDBiQ9ZW27.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZW27-1 [UniParc]FASTAAdd to Basket

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    MAEKEEDVKL LGFWASPFTR RVEMAFKLKG VPYEYLEQDI VNKSPLLLQI    50
    NPVYKKVPVL VYKGKILSES HVILEYIDQI WKNNPILPQD PYEKAMALFW 100
    AKFVDEQVGP VAFMSVAKAE KGVEVAIKEA QELFMFLEKE VTGKDFFGGK 150
    TIGFLDLVAG SMIPFCLARG WEGMGIDMIP EEKFPELNRW IKNLKEIEIV 200
    RECIPPREEQ IEHMKKVVER IKSA 224
    Length:224
    Mass (Da):25,839
    Last modified:May 1, 1999 - v1
    Checksum:i3810B34656614BE0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731G → D in AAK62449. (PubMed:14593172)Curated
    Sequence conflicti173 – 1731G → D in AAO30062. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288186 mRNA. Translation: AAG30135.1.
    AC004561 Genomic DNA. Translation: AAC95192.1.
    CP002685 Genomic DNA. Translation: AEC08257.1.
    AF387004 mRNA. Translation: AAK62449.1.
    BT003399 mRNA. Translation: AAO30062.1.
    PIRiF84696.
    RefSeqiNP_180507.1. NM_128500.3.
    UniGeneiAt.12688.
    At.67637.
    At.68148.

    Genome annotation databases

    EnsemblPlantsiAT2G29460.1; AT2G29460.1; AT2G29460.
    GeneIDi817495.
    KEGGiath:AT2G29460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288186 mRNA. Translation: AAG30135.1 .
    AC004561 Genomic DNA. Translation: AAC95192.1 .
    CP002685 Genomic DNA. Translation: AEC08257.1 .
    AF387004 mRNA. Translation: AAK62449.1 .
    BT003399 mRNA. Translation: AAO30062.1 .
    PIRi F84696.
    RefSeqi NP_180507.1. NM_128500.3.
    UniGenei At.12688.
    At.67637.
    At.68148.

    3D structure databases

    ProteinModelPortali Q9ZW27.
    SMRi Q9ZW27. Positions 6-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G29460.1-P.

    Proteomic databases

    PRIDEi Q9ZW27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G29460.1 ; AT2G29460.1 ; AT2G29460 .
    GeneIDi 817495.
    KEGGi ath:AT2G29460.

    Organism-specific databases

    TAIRi AT2G29460.

    Phylogenomic databases

    eggNOGi NOG288793.
    HOGENOMi HOG000125749.
    InParanoidi Q9ZW27.
    KOi K00799.
    OMAi EYLEQDI.
    PhylomeDBi Q9ZW27.

    Enzyme and pathway databases

    BioCyci ARA:AT2G29460-MONOMER.

    Gene expression databases

    Genevestigatori Q9ZW27.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
      Strain: cv. Columbia.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
      Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
      J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiGSTU4_ARATH
    AccessioniPrimary (citable) accession number: Q9ZW27
    Secondary accession number(s): Q94EZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3