Q9ZW26 (GSTU6_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase U6
Short name=AtGSTU6
EC=2.5.1.18

Alternative name(s):
GST class-tau member 6
Glutathione S-transferase 24

Gene names

Name:	GSTU6
Synonyms:	GST24
Ordered Locus Names:	At2g29440
ORF Names:	F16P2.18

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subcellular location	Cytoplasm › cytosol Probable.
Sequence similarities	Belongs to the GST superfamily. Tau family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Biological process	Detoxification
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to toxin Inferred from electronic annotation. Source: UniProtKB-KW toxin catabolic process Traceable author statement Ref.1. Source: TAIR
Cellular_component	cytosol Inferred from direct assay PubMed 21166475. Source: TAIR
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Glutathione S-transferase U6		PRO_0000413552
Regions
	Domain	5 – 84	80	GST N-terminal
	Domain	89 – 216	128	GST C-terminal
	Region	15 – 16	2	Glutathione binding By similarity
	Region	41 – 42	2	Glutathione binding By similarity
	Region	55 – 56	2	Glutathione binding By similarity
	Region	68 – 69	2	Glutathione binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZW26 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: AD15D4CD0C91B95F	FASTA	223	25,618
	10 20 30 40 50 60 MGKNEEVKLL GIWASPFSRR IEMALKLKGV PYEYLEEDLE NKSSLLLALS PIHKKIPVLV 70 80 90 100 110 120 HNGKTIIESH VILEYIDETW KHNPILPQDP FQRSKARVLA KLVDEKIVNV GFASLAKTEK 130 140 150 160 170 180 GREVLIEQTR ELIMCLEKEL AGKDYFGGKT VGFLDFVAGS MIPFCLERAW EGMGVEMITE 190 200 210 220 KKFPEYNKWV KKLKEVEIVV DCIPLREKHI EHMNNMAEKI RSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Probing the diversity of the Arabidopsis glutathione S-transferase gene family." Wagner U., Edwards R., Dixon D.P., Mauch F. Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Arabidopsis ORF clones." Kim C.J., Chen H., Shinn P., Ecker J.R. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF288187 mRNA. Translation: AAG30136.1. AC004561 Genomic DNA. Translation: AAC95194.1. CP002685 Genomic DNA. Translation: AEC08254.1. BT024843 mRNA. Translation: ABD60726.1. AK229012 mRNA. Translation: BAF00899.1.
IPI	IPI00525848.
PIR	D84696.
RefSeq	NP_180505.1. NM_128498.4.
UniGene	At.12687.
3D structure databases
HSSP	HSSP built from PDB template 1OYJ based on UniProtKB O65032.
ProteinModelPortal	Q9ZW26.
SMR	Q9ZW26. Positions 5-210.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT2G29440.1-P.
Proteomic databases
PaxDb	Q9ZW26.
PRIDE	Q9ZW26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G29440.1; AT2G29440.1; AT2G29440.
GeneID	817493.
KEGG	ath:AT2G29440.
Organism-specific databases
TAIR	At2g29440.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125749.
InParanoid	Q9ZW26.
KO	K00799.
OMA	RIEMALK.
PhylomeDB	Q9ZW26.
ProtClustDB	CLSN2913215.
Gene expression databases
Genevestigator	Q9ZW26.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTU6_ARATH

Accession

Primary (citable) accession number: Q9ZW26

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program