Q9ZVQ4 (GSTZ2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase Z2
Short name=AtGSTZ2
EC=2.5.1.18

Alternative name(s):
GST class-zeta member 2

Gene names

Name:	GSTZ2
Ordered Locus Names:	At2g02380
ORF Names:	T16F16.17

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the GST superfamily. Zeta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Biological process	Detoxification
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro response to toxin Inferred from electronic annotation. Source: UniProtKB-KW toxin catabolic process Traceable author statement Ref.3. Source: TAIR
Cellular_component	cytoplasm Non-traceable author statement Ref.3. Source: TAIR cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Glutathione S-transferase Z2		PRO_0000186030
Regions
	Domain	10 – 91	82	GST N-terminal
	Domain	96 – 221	126	GST C-terminal
	Region	20 – 25	6	Glutathione binding By similarity
	Region	20 – 21	2	Glutathione binding By similarity
	Region	49 – 50	2	Glutathione binding By similarity
	Region	62 – 63	2	Glutathione binding By similarity
	Region	75 – 76	2	Glutathione binding By similarity
	Region	119 – 121	3	Glutathione binding By similarity
Sites
	Binding site	49	1	Glutathione By similarity
	Binding site	63	1	Glutathione; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	115	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZVQ4 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: AAE7E85746610512	FASTA	223	25,352
	10 20 30 40 50 60 MSYVTDFYQA KLKLYSYWRS SCAHRVRIAL TLKGLDYEYI PVNLLKGDQS DSDFKKINPM 70 80 90 100 110 120 GTVPALVDGD VVINDSFAII MYLDDKYPEP PLLPSDYHKR AVNYQATSIV MSGIQPHQNM 130 140 150 160 170 180 ALFRYLEDKI NAEEKTAWIT NAITKGFTAL EKLLVSCAGK YATGDEVYLA DLFLAPQIHA 190 200 210 220 AFNRFHINME PFPTLARFYE SYNELPAFQN AVPEKQPDTP STI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Probing the diversity of the Arabidopsis glutathione S-transferase gene family." Wagner U., Edwards R., Dixon D.P., Mauch F. Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005312 Genomic DNA. Translation: AAC78520.1. CP002685 Genomic DNA. Translation: AEC05572.1.
IPI	IPI00516977.
PIR	A84436.
RefSeq	NP_178343.1. NM_126295.1.
UniGene	At.70421.
3D structure databases
ProteinModelPortal	Q9ZVQ4.
SMR	Q9ZVQ4. Positions 11-222.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT2G02380.1-P.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G02380.1; AT2G02380.1; AT2G02380.
GeneID	814769.
KEGG	ath:AT2G02380.
Organism-specific databases
TAIR	At2g02380.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125758.
InParanoid	Q9ZVQ4.
KO	K01800.
OMA	YLIPQLY.
PhylomeDB	Q9ZVQ4.
ProtClustDB	CLSN2683685.
Gene expression databases
Genevestigator	Q9ZVQ4.
GermOnline	AT2G02380. Arabidopsis thaliana.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR005955. Mal_ac_isom. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR01262. maiA. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTZ2_ARATH

Accession

Primary (citable) accession number: Q9ZVQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program