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Q9ZVQ4

- GSTZ2_ARATH

UniProt

Q9ZVQ4 - GSTZ2_ARATH

Protein

Glutathione S-transferase Z2

Gene

GSTZ2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491GlutathioneBy similarity
    Binding sitei63 – 631Glutathione; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei115 – 1151GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro
    2. response to toxic substance Source: UniProtKB-KW
    3. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification

    Enzyme and pathway databases

    BioCyciARA:AT2G02380-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Z2 (EC:2.5.1.18)
    Short name:
    AtGSTZ2
    Alternative name(s):
    GST class-zeta member 2
    Gene namesi
    Name:GSTZ2
    Ordered Locus Names:At2g02380
    ORF Names:T16F16.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G02380.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Glutathione S-transferase Z2PRO_0000186030Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZVQ4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ZVQ4.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G02380.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZVQ4.
    SMRiQ9ZVQ4. Positions 11-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 9182GST N-terminalAdd
    BLAST
    Domaini96 – 221126GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 256Glutathione bindingBy similarity
    Regioni20 – 212Glutathione bindingBy similarity
    Regioni49 – 502Glutathione bindingBy similarity
    Regioni62 – 632Glutathione bindingBy similarity
    Regioni75 – 762Glutathione bindingBy similarity
    Regioni119 – 1213Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Zeta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125758.
    InParanoidiQ9ZVQ4.
    KOiK01800.
    OMAiRVRTFLM.
    PhylomeDBiQ9ZVQ4.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01262. maiA. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZVQ4-1 [UniParc]FASTAAdd to Basket

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    MSYVTDFYQA KLKLYSYWRS SCAHRVRIAL TLKGLDYEYI PVNLLKGDQS    50
    DSDFKKINPM GTVPALVDGD VVINDSFAII MYLDDKYPEP PLLPSDYHKR 100
    AVNYQATSIV MSGIQPHQNM ALFRYLEDKI NAEEKTAWIT NAITKGFTAL 150
    EKLLVSCAGK YATGDEVYLA DLFLAPQIHA AFNRFHINME PFPTLARFYE 200
    SYNELPAFQN AVPEKQPDTP STI 223
    Length:223
    Mass (Da):25,352
    Last modified:May 1, 1999 - v1
    Checksum:iAAE7E85746610512
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005312 Genomic DNA. Translation: AAC78520.1.
    CP002685 Genomic DNA. Translation: AEC05572.1.
    PIRiA84436.
    RefSeqiNP_178343.1. NM_126295.1.
    UniGeneiAt.70421.

    Genome annotation databases

    EnsemblPlantsiAT2G02380.1; AT2G02380.1; AT2G02380.
    GeneIDi814769.
    KEGGiath:AT2G02380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005312 Genomic DNA. Translation: AAC78520.1 .
    CP002685 Genomic DNA. Translation: AEC05572.1 .
    PIRi A84436.
    RefSeqi NP_178343.1. NM_126295.1.
    UniGenei At.70421.

    3D structure databases

    ProteinModelPortali Q9ZVQ4.
    SMRi Q9ZVQ4. Positions 11-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G02380.1-P.

    Proteomic databases

    PRIDEi Q9ZVQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G02380.1 ; AT2G02380.1 ; AT2G02380 .
    GeneIDi 814769.
    KEGGi ath:AT2G02380.

    Organism-specific databases

    TAIRi AT2G02380.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125758.
    InParanoidi Q9ZVQ4.
    KOi K01800.
    OMAi RVRTFLM.
    PhylomeDBi Q9ZVQ4.

    Enzyme and pathway databases

    BioCyci ARA:AT2G02380-MONOMER.

    Miscellaneous databases

    PROi Q9ZVQ4.

    Gene expression databases

    Genevestigatori Q9ZVQ4.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01262. maiA. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiGSTZ2_ARATH
    AccessioniPrimary (citable) accession number: Q9ZVQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3