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Q9ZVQ4 (GSTZ2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase Z2

Short name=AtGSTZ2
EC=2.5.1.18
Alternative name(s):
GST class-zeta member 2
Gene names
Name:GSTZ2
Ordered Locus Names:At2g02380
ORF Names:T16F16.17
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the GST superfamily. Zeta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Biological processDetoxification
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family metabolic process

Inferred from electronic annotation. Source: InterPro

response to toxic substance

Inferred from electronic annotation. Source: UniProtKB-KW

toxin catabolic process

Traceable author statement Ref.3. Source: TAIR

   Cellular_componentcytoplasm

Non-traceable author statement Ref.3. Source: TAIR

cytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Glutathione S-transferase Z2
PRO_0000186030

Regions

Domain10 – 9182GST N-terminal
Domain96 – 221126GST C-terminal
Region20 – 256Glutathione binding By similarity
Region20 – 212Glutathione binding By similarity
Region49 – 502Glutathione binding By similarity
Region62 – 632Glutathione binding By similarity
Region75 – 762Glutathione binding By similarity
Region119 – 1213Glutathione binding By similarity

Sites

Binding site491Glutathione By similarity
Binding site631Glutathione; via amide nitrogen and carbonyl oxygen By similarity
Binding site1151Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZVQ4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: AAE7E85746610512

FASTA22325,352
        10         20         30         40         50         60 
MSYVTDFYQA KLKLYSYWRS SCAHRVRIAL TLKGLDYEYI PVNLLKGDQS DSDFKKINPM 

        70         80         90        100        110        120 
GTVPALVDGD VVINDSFAII MYLDDKYPEP PLLPSDYHKR AVNYQATSIV MSGIQPHQNM 

       130        140        150        160        170        180 
ALFRYLEDKI NAEEKTAWIT NAITKGFTAL EKLLVSCAGK YATGDEVYLA DLFLAPQIHA 

       190        200        210        220 
AFNRFHINME PFPTLARFYE SYNELPAFQN AVPEKQPDTP STI 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
Wagner U., Edwards R., Dixon D.P., Mauch F.
Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005312 Genomic DNA. Translation: AAC78520.1.
CP002685 Genomic DNA. Translation: AEC05572.1.
PIRA84436.
RefSeqNP_178343.1. NM_126295.1.
UniGeneAt.70421.

3D structure databases

ProteinModelPortalQ9ZVQ4.
SMRQ9ZVQ4. Positions 11-222.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT2G02380.1-P.

Proteomic databases

PRIDEQ9ZVQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G02380.1; AT2G02380.1; AT2G02380.
GeneID814769.
KEGGath:AT2G02380.

Organism-specific databases

TAIRAT2G02380.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000125758.
InParanoidQ9ZVQ4.
KOK01800.
OMAAWCATWI.
PhylomeDBQ9ZVQ4.
ProtClustDBCLSN2683685.

Enzyme and pathway databases

BioCycARA:AT2G02380-MONOMER.

Gene expression databases

GenevestigatorQ9ZVQ4.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01262. maiA. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9ZVQ4.

Entry information

Entry nameGSTZ2_ARATH
AccessionPrimary (citable) accession number: Q9ZVQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names