Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ZVQ3

- GSTZ1_ARATH

UniProt

Q9ZVQ3 - GSTZ1_ARATH

Protein

Glutathione S-transferase Z1

Gene

GSTZ1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts a maleylacetone isomerase. Also catalyzes the glutathione-dependent dehalogenation of dichloroacetic acid to glyoxylic acid. In vitro, possesses glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461GlutathioneBy similarity
    Binding sitei60 – 601Glutathione; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei112 – 1121GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC
    2. isomerase activity Source: UniProtKB-KW
    3. maleylacetoacetate isomerase activity Source: TAIR
    4. peroxidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro
    2. homogentisate catabolic process Source: TAIR
    3. response to stress Source: UniProtKB-KW
    4. response to toxic substance Source: UniProtKB-KW
    5. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Isomerase, Oxidoreductase, Peroxidase, Transferase

    Keywords - Biological processi

    Detoxification, Stress response

    Enzyme and pathway databases

    BioCyciARA:AT2G02390-MONOMER.
    ARA:GQT-1345-MONOMER.
    ARA:GQT-1346-MONOMER.
    BRENDAi5.2.1.2. 399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Z1 (EC:2.5.1.18)
    Short name:
    AtGSTZ1
    Alternative name(s):
    GST class-zeta member 1
    Glutathione S-transferase 18
    Maleylacetone isomerase (EC:5.2.1.-)
    Short name:
    MAI
    Gene namesi
    Name:GSTZ1
    Synonyms:GST18, GSTZ
    Ordered Locus Names:At2g02390
    ORF Names:T16F16.18
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G02390.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. cytosol Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Glutathione S-transferase Z1PRO_0000186029Add
    BLAST

    Proteomic databases

    PaxDbiQ9ZVQ3.
    PRIDEiQ9ZVQ3.

    Expressioni

    Inductioni

    By salicylic acid, methyl jasmonate, auxin, H2O2, and the pathogen Hyaloperonospora parasitica.1 Publication

    Gene expression databases

    ArrayExpressiQ9ZVQ3.
    GenevestigatoriQ9ZVQ3.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    Secondary structure

    1
    221
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 134
    Helixi18 – 2912
    Beta strandi35 – 384
    Turni41 – 444
    Helixi45 – 473
    Helixi49 – 546
    Beta strandi60 – 656
    Beta strandi68 – 725
    Helixi73 – 8311
    Helixi94 – 10916
    Helixi138 – 15114
    Beta strandi156 – 1583
    Beta strandi161 – 1633
    Helixi166 – 18217
    Helixi190 – 19910
    Helixi203 – 2086
    Helixi210 – 2123

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1E6BX-ray1.65A1-221[»]
    ProteinModelPortaliQ9ZVQ3.
    SMRiQ9ZVQ3. Positions 8-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ZVQ3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 8882GST N-terminalAdd
    BLAST
    Domaini93 – 218126GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 226Glutathione bindingBy similarity
    Regioni17 – 182Glutathione bindingBy similarity
    Regioni46 – 472Glutathione bindingBy similarity
    Regioni59 – 602Glutathione bindingBy similarity
    Regioni72 – 732Glutathione bindingBy similarity
    Regioni116 – 1183Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Zeta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125758.
    InParanoidiQ9ZVQ3.
    KOiK01800.
    OMAiDACTRLP.
    PhylomeDBiQ9ZVQ3.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01262. maiA. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ZVQ3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANSGEEKLK LYSYWRSSCA HRVRIALALK GLDYEYIPVN LLKGDQFDSD    50
    FKKINPMGTV PALVDGDVVI NDSFAIIMYL DEKYPEPPLL PRDLHKRAVN 100
    YQAMSIVLSG IQPHQNLAVI RYIEEKINVE EKTAWVNNAI TKGFTALEKL 150
    LVNCAGKHAT GDEIYLADLF LAPQIHGAIN RFQINMEPYP TLAKCYESYN 200
    ELPAFQNALP EKQPDAPSST I 221
    Length:221
    Mass (Da):24,888
    Last modified:May 1, 1999 - v1
    Checksum:i106BDC8EF3E745BF
    GO
    Isoform 2 (identifier: Q9ZVQ3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         49-49: S → SVYRFDLQ

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):25,810
    Checksum:i80B56ED20594C9E8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei49 – 491S → SVYRFDLQ in isoform 2. 1 PublicationVSP_041936

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288182 mRNA. Translation: AAG30131.1.
    AJ278293 mRNA. Translation: CAC19475.1.
    AY208155 mRNA. Translation: AAO60039.1.
    AC005312 Genomic DNA. Translation: AAC78521.1.
    CP002685 Genomic DNA. Translation: AEC05573.1.
    CP002685 Genomic DNA. Translation: AEC05575.1.
    AY052332 mRNA. Translation: AAK96525.1.
    AY061901 mRNA. Translation: AAL31228.1.
    AK226342 mRNA. Translation: BAE98491.1.
    PIRiB84436.
    RefSeqiNP_178344.1. NM_126296.4. [Q9ZVQ3-1]
    NP_973400.1. NM_201671.2. [Q9ZVQ3-2]
    UniGeneiAt.10192.

    Genome annotation databases

    EnsemblPlantsiAT2G02390.1; AT2G02390.1; AT2G02390. [Q9ZVQ3-1]
    GeneIDi814770.
    KEGGiath:AT2G02390.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288182 mRNA. Translation: AAG30131.1 .
    AJ278293 mRNA. Translation: CAC19475.1 .
    AY208155 mRNA. Translation: AAO60039.1 .
    AC005312 Genomic DNA. Translation: AAC78521.1 .
    CP002685 Genomic DNA. Translation: AEC05573.1 .
    CP002685 Genomic DNA. Translation: AEC05575.1 .
    AY052332 mRNA. Translation: AAK96525.1 .
    AY061901 mRNA. Translation: AAL31228.1 .
    AK226342 mRNA. Translation: BAE98491.1 .
    PIRi B84436.
    RefSeqi NP_178344.1. NM_126296.4. [Q9ZVQ3-1 ]
    NP_973400.1. NM_201671.2. [Q9ZVQ3-2 ]
    UniGenei At.10192.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1E6B X-ray 1.65 A 1-221 [» ]
    ProteinModelPortali Q9ZVQ3.
    SMRi Q9ZVQ3. Positions 8-220.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9ZVQ3.
    PRIDEi Q9ZVQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G02390.1 ; AT2G02390.1 ; AT2G02390 . [Q9ZVQ3-1 ]
    GeneIDi 814770.
    KEGGi ath:AT2G02390.

    Organism-specific databases

    TAIRi AT2G02390.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125758.
    InParanoidi Q9ZVQ3.
    KOi K01800.
    OMAi DACTRLP.
    PhylomeDBi Q9ZVQ3.

    Enzyme and pathway databases

    BioCyci ARA:AT2G02390-MONOMER.
    ARA:GQT-1345-MONOMER.
    ARA:GQT-1346-MONOMER.
    BRENDAi 5.2.1.2. 399.

    Miscellaneous databases

    EvolutionaryTracei Q9ZVQ3.
    PROi Q9ZVQ3.

    Gene expression databases

    ArrayExpressi Q9ZVQ3.
    Genevestigatori Q9ZVQ3.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01262. maiA. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, GENE FAMILY, NOMENCLATURE.
      Strain: cv. Columbia.
    2. "Characterisation of a zeta class glutathione transferase from Arabidopsis thaliana with a putative role in tyrosine catabolism."
      Dixon D.P., Cole D.J., Edwards R.
      Arch. Biochem. Biophys. 384:407-412(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: cv. Columbia.
    3. "Arabidopsis thaliana ecotype Columbia for glutathione S-transferase zeta (AtGSTZ) mRNA."
      Chen D., Kawarasaki Y., Nakano H., Yamane T.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    5. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    7. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    8. "The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism."
      Thom R., Dixon D.P., Edwards R., Cole D.J., Lapthorn A.J.
      J. Mol. Biol. 308:949-962(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

    Entry informationi

    Entry nameiGSTZ1_ARATH
    AccessioniPrimary (citable) accession number: Q9ZVQ3
    Secondary accession number(s): Q0WWK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3