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Q9ZVQ3

- GSTZ1_ARATH

UniProt

Q9ZVQ3 - GSTZ1_ARATH

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Protein

Glutathione S-transferase Z1

Gene

GSTZ1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts a maleylacetone isomerase. Also catalyzes the glutathione-dependent dehalogenation of dichloroacetic acid to glyoxylic acid. In vitro, possesses glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461GlutathioneBy similarity
Binding sitei60 – 601Glutathione; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei112 – 1121GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
  2. isomerase activity Source: UniProtKB-KW
  3. maleylacetoacetate isomerase activity Source: TAIR
  4. peroxidase activity Source: UniProtKB-KW

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
  2. homogentisate catabolic process Source: TAIR
  3. response to stress Source: UniProtKB-KW
  4. response to toxic substance Source: UniProtKB-KW
  5. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Oxidoreductase, Peroxidase, Transferase

Keywords - Biological processi

Detoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT2G02390-MONOMER.
ARA:GQT-1345-MONOMER.
ARA:GQT-1346-MONOMER.
BRENDAi5.2.1.2. 399.
ReactomeiREACT_230500. Glutathione conjugation.
REACT_258218. Phenylalanine and tyrosine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Z1 (EC:2.5.1.18)
Short name:
AtGSTZ1
Alternative name(s):
GST class-zeta member 1
Glutathione S-transferase 18
Maleylacetone isomerase (EC:5.2.1.-)
Short name:
MAI
Gene namesi
Name:GSTZ1
Synonyms:GST18, GSTZ
Ordered Locus Names:At2g02390
ORF Names:T16F16.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G02390.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytosol Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Glutathione S-transferase Z1PRO_0000186029Add
BLAST

Proteomic databases

PaxDbiQ9ZVQ3.
PRIDEiQ9ZVQ3.

Expressioni

Inductioni

By salicylic acid, methyl jasmonate, auxin, H2O2, and the pathogen Hyaloperonospora parasitica.1 Publication

Gene expression databases

ExpressionAtlasiQ9ZVQ3. baseline and differential.
GenevestigatoriQ9ZVQ3.

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
221
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 134Combined sources
Helixi18 – 2912Combined sources
Beta strandi35 – 384Combined sources
Turni41 – 444Combined sources
Helixi45 – 473Combined sources
Helixi49 – 546Combined sources
Beta strandi60 – 656Combined sources
Beta strandi68 – 725Combined sources
Helixi73 – 8311Combined sources
Helixi94 – 10916Combined sources
Helixi138 – 15114Combined sources
Beta strandi156 – 1583Combined sources
Beta strandi161 – 1633Combined sources
Helixi166 – 18217Combined sources
Helixi190 – 19910Combined sources
Helixi203 – 2086Combined sources
Helixi210 – 2123Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E6BX-ray1.65A1-221[»]
ProteinModelPortaliQ9ZVQ3.
SMRiQ9ZVQ3. Positions 8-220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZVQ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8882GST N-terminalAdd
BLAST
Domaini93 – 218126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 226Glutathione bindingBy similarity
Regioni17 – 182Glutathione bindingBy similarity
Regioni46 – 472Glutathione bindingBy similarity
Regioni59 – 602Glutathione bindingBy similarity
Regioni72 – 732Glutathione bindingBy similarity
Regioni116 – 1183Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Zeta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125758.
InParanoidiQ9ZVQ3.
KOiK01800.
OMAiDACTRLP.
PhylomeDBiQ9ZVQ3.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ZVQ3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANSGEEKLK LYSYWRSSCA HRVRIALALK GLDYEYIPVN LLKGDQFDSD
60 70 80 90 100
FKKINPMGTV PALVDGDVVI NDSFAIIMYL DEKYPEPPLL PRDLHKRAVN
110 120 130 140 150
YQAMSIVLSG IQPHQNLAVI RYIEEKINVE EKTAWVNNAI TKGFTALEKL
160 170 180 190 200
LVNCAGKHAT GDEIYLADLF LAPQIHGAIN RFQINMEPYP TLAKCYESYN
210 220
ELPAFQNALP EKQPDAPSST I
Length:221
Mass (Da):24,888
Last modified:May 1, 1999 - v1
Checksum:i106BDC8EF3E745BF
GO
Isoform 2 (identifier: Q9ZVQ3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-49: S → SVYRFDLQ

Note: No experimental confirmation available.

Show »
Length:228
Mass (Da):25,810
Checksum:i80B56ED20594C9E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei49 – 491S → SVYRFDLQ in isoform 2. 1 PublicationVSP_041936

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288182 mRNA. Translation: AAG30131.1.
AJ278293 mRNA. Translation: CAC19475.1.
AY208155 mRNA. Translation: AAO60039.1.
AC005312 Genomic DNA. Translation: AAC78521.1.
CP002685 Genomic DNA. Translation: AEC05573.1.
CP002685 Genomic DNA. Translation: AEC05575.1.
AY052332 mRNA. Translation: AAK96525.1.
AY061901 mRNA. Translation: AAL31228.1.
AK226342 mRNA. Translation: BAE98491.1.
PIRiB84436.
RefSeqiNP_178344.1. NM_126296.4. [Q9ZVQ3-1]
NP_973400.1. NM_201671.2. [Q9ZVQ3-2]
UniGeneiAt.10192.

Genome annotation databases

EnsemblPlantsiAT2G02390.1; AT2G02390.1; AT2G02390. [Q9ZVQ3-1]
GeneIDi814770.
KEGGiath:AT2G02390.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288182 mRNA. Translation: AAG30131.1 .
AJ278293 mRNA. Translation: CAC19475.1 .
AY208155 mRNA. Translation: AAO60039.1 .
AC005312 Genomic DNA. Translation: AAC78521.1 .
CP002685 Genomic DNA. Translation: AEC05573.1 .
CP002685 Genomic DNA. Translation: AEC05575.1 .
AY052332 mRNA. Translation: AAK96525.1 .
AY061901 mRNA. Translation: AAL31228.1 .
AK226342 mRNA. Translation: BAE98491.1 .
PIRi B84436.
RefSeqi NP_178344.1. NM_126296.4. [Q9ZVQ3-1 ]
NP_973400.1. NM_201671.2. [Q9ZVQ3-2 ]
UniGenei At.10192.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E6B X-ray 1.65 A 1-221 [» ]
ProteinModelPortali Q9ZVQ3.
SMRi Q9ZVQ3. Positions 8-220.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9ZVQ3.
PRIDEi Q9ZVQ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G02390.1 ; AT2G02390.1 ; AT2G02390 . [Q9ZVQ3-1 ]
GeneIDi 814770.
KEGGi ath:AT2G02390.

Organism-specific databases

TAIRi AT2G02390.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125758.
InParanoidi Q9ZVQ3.
KOi K01800.
OMAi DACTRLP.
PhylomeDBi Q9ZVQ3.

Enzyme and pathway databases

BioCyci ARA:AT2G02390-MONOMER.
ARA:GQT-1345-MONOMER.
ARA:GQT-1346-MONOMER.
BRENDAi 5.2.1.2. 399.
Reactomei REACT_230500. Glutathione conjugation.
REACT_258218. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

EvolutionaryTracei Q9ZVQ3.
PROi Q9ZVQ3.

Gene expression databases

ExpressionAtlasi Q9ZVQ3. baseline and differential.
Genevestigatori Q9ZVQ3.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01262. maiA. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Characterisation of a zeta class glutathione transferase from Arabidopsis thaliana with a putative role in tyrosine catabolism."
    Dixon D.P., Cole D.J., Edwards R.
    Arch. Biochem. Biophys. 384:407-412(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: cv. Columbia.
  3. "Arabidopsis thaliana ecotype Columbia for glutathione S-transferase zeta (AtGSTZ) mRNA."
    Chen D., Kawarasaki Y., Nakano H., Yamane T.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  5. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  7. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  8. "The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism."
    Thom R., Dixon D.P., Edwards R., Cole D.J., Lapthorn A.J.
    J. Mol. Biol. 308:949-962(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

Entry informationi

Entry nameiGSTZ1_ARATH
AccessioniPrimary (citable) accession number: Q9ZVQ3
Secondary accession number(s): Q0WWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3