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Protein

Probable tyrosine-protein phosphatase At1g05000

Gene

At1g05000

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciARA:GQT-352-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein phosphatase At1g05000 (EC:3.1.3.48)
Gene namesi
Ordered Locus Names:At1g05000
ORF Names:T7A14.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G05000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Probable tyrosine-protein phosphatase At1g05000PRO_0000094923Add
BLAST

Proteomic databases

PRIDEiQ9ZVN4.

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZVN4. baseline and differential.

Interactioni

Subunit structurei

Homomultimer.Curated

Protein-protein interaction databases

BioGridi24583. 17 interactions.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi60 – 634Combined sources
Beta strandi66 – 705Combined sources
Helixi74 – 8310Combined sources
Beta strandi86 – 905Combined sources
Helixi98 – 10710Combined sources
Beta strandi110 – 1134Combined sources
Helixi121 – 1233Combined sources
Helixi128 – 13912Combined sources
Helixi141 – 1433Combined sources
Beta strandi145 – 1495Combined sources
Beta strandi151 – 1555Combined sources
Helixi156 – 16712Combined sources
Helixi172 – 18312Combined sources
Helixi184 – 1863Combined sources
Helixi189 – 1968Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XRIX-ray3.30A/B52-202[»]
2Q47X-ray3.30A/B52-202[»]
ProteinModelPortaliQ9ZVN4.
SMRiQ9ZVN4. Positions 52-202.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZVN4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 104Poly-Thr

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2365.
HOGENOMiHOG000188365.
InParanoidiQ9ZVN4.
KOiK18045.
PhylomeDBiQ9ZVN4.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR020428. Tyr_Pase_dualsp-Pase_euk.
IPR004861. Tyr_Pase_SIW14-like.
[Graphical view]
PfamiPF03162. Y_phosphatase2. 1 hit.
[Graphical view]
PRINTSiPR01911. PFDSPHPHTASE.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9ZVN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLVEKTTTT EQDNGEDFCR TIIEVSEVNR NVFQAPGGEA DPFRVVSGEE
60 70 80 90 100
LHLIPPLNFS MVDNGIFRSG FPDSANFSFL QTLGLRSIIY LCPEPYPESN
110 120 130 140 150
LQFLKSNGIR LFQFGIEGNK EPFVNIPDHK IRMALKVLLD EKNHPVLIHC
160 170 180 190 200
KRGKHRTGCL VGCLRKLQKW CLTSIFDEYQ RFAAAKARVS DQRFMEIFDV
210
SSFSHIPMSF SCSIR
Length:215
Mass (Da):24,537
Last modified:May 1, 1999 - v1
Checksum:i24BCB3033CBCFA3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005322 Genomic DNA. Translation: AAC97999.1.
CP002684 Genomic DNA. Translation: AEE27777.1.
BT005210 mRNA. Translation: AAO63274.1.
PIRiG86183.
RefSeqiNP_171993.1. NM_100379.2. [Q9ZVN4-1]
UniGeneiAt.43231.

Genome annotation databases

EnsemblPlantsiAT1G05000.1; AT1G05000.1; AT1G05000. [Q9ZVN4-1]
GeneIDi839348.
KEGGiath:AT1G05000.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005322 Genomic DNA. Translation: AAC97999.1.
CP002684 Genomic DNA. Translation: AEE27777.1.
BT005210 mRNA. Translation: AAO63274.1.
PIRiG86183.
RefSeqiNP_171993.1. NM_100379.2. [Q9ZVN4-1]
UniGeneiAt.43231.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XRIX-ray3.30A/B52-202[»]
2Q47X-ray3.30A/B52-202[»]
ProteinModelPortaliQ9ZVN4.
SMRiQ9ZVN4. Positions 52-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24583. 17 interactions.

Proteomic databases

PRIDEiQ9ZVN4.

Protocols and materials databases

DNASUi839348.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G05000.1; AT1G05000.1; AT1G05000. [Q9ZVN4-1]
GeneIDi839348.
KEGGiath:AT1G05000.

Organism-specific databases

TAIRiAT1G05000.

Phylogenomic databases

eggNOGiCOG2365.
HOGENOMiHOG000188365.
InParanoidiQ9ZVN4.
KOiK18045.
PhylomeDBiQ9ZVN4.

Enzyme and pathway databases

BioCyciARA:GQT-352-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9ZVN4.
PROiQ9ZVN4.

Gene expression databases

ExpressionAtlasiQ9ZVN4. baseline and differential.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR020428. Tyr_Pase_dualsp-Pase_euk.
IPR004861. Tyr_Pase_SIW14-like.
[Graphical view]
PfamiPF03162. Y_phosphatase2. 1 hit.
[Graphical view]
PRINTSiPR01911. PFDSPHPHTASE.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "X-ray structure of a putative phosphoprotein phosphatase from Arabidopsis thaliana gene At1g05000."
    Center for eukaryotic structural genomics (CESG)
    Submitted (FEB-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 52-202.

Entry informationi

Entry nameiY1500_ARATH
AccessioniPrimary (citable) accession number: Q9ZVN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.