Q9ZVN4 (Y1500_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tyrosine-protein phosphatase At1g05000
EC=3.1.3.48

Gene names

Ordered Locus Names:	At1g05000
ORF Names:	T7A14.14

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Homomultimer Probable.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protein phosphatase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9ZVN4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 215

215

Probable tyrosine-protein phosphatase At1g05000

PRO_0000094923

Regions

Compositional bias

7 – 10

4

Poly-Thr

Sites

Active site

150

1

Phosphocysteine intermediate By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

215

Helix Strand Turn

Details...

Beta strand

60 – 63

4

Beta strand

66 – 70

5

Helix

74 – 83

10

Beta strand

86 – 90

5

Helix

98 – 107

10

Beta strand

110 – 113

4

Helix

121 – 123

3

Helix

128 – 139

12

Helix

141 – 143

3

Beta strand

145 – 149

5

Beta strand

151 – 155

5

Helix

156 – 167

12

Helix

172 – 183

12

Helix

184 – 186

3

Helix

189 – 196

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 24BCB3033CBCFA3A	FASTA	215	24,537
	10 20 30 40 50 60 MKLVEKTTTT EQDNGEDFCR TIIEVSEVNR NVFQAPGGEA DPFRVVSGEE LHLIPPLNFS 70 80 90 100 110 120 MVDNGIFRSG FPDSANFSFL QTLGLRSIIY LCPEPYPESN LQFLKSNGIR LFQFGIEGNK 130 140 150 160 170 180 EPFVNIPDHK IRMALKVLLD EKNHPVLIHC KRGKHRTGCL VGCLRKLQKW CLTSIFDEYQ 190 200 210 RFAAAKARVS DQRFMEIFDV SSFSHIPMSF SCSIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"X-ray structure of a putative phosphoprotein phosphatase from Arabidopsis thaliana gene At1g05000." Center for eukaryotic structural genomics (CESG) Submitted (FEB-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 52-202.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC005322 Genomic DNA. Translation: AAC97999.1.
CP002684 Genomic DNA. Translation: AEE27777.1.
BT005210 mRNA. Translation: AAO63274.1.

IPI

IPI00541248.

PIR

G86183.

RefSeq

NP_171993.1. NM_100379.2.

UniGene

At.43231.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XRI	X-ray	3.30	A/B	52-202	[»]
2Q47	X-ray	3.30	A/B	52-202	[»]

ProteinModelPortal

Q9ZVN4.

SMR

Q9ZVN4. Positions 52-202.

ModBase

Search...

Protocols and materials databases

DNASU

839348.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblPlants

AT1G05000.1; AT1G05000.1; AT1G05000.

GeneID

839348.

KEGG

ath:AT1G05000.

Organism-specific databases

TAIR

At1g05000.

Phylogenomic databases

eggNOG

COG2365.

HOGENOM

HOG000188365.

InParanoid

Q9ZVN4.

PhylomeDB

Q9ZVN4.

ProtClustDB

CLSN2681967.

Gene expression databases

ArrayExpress

Q9ZVN4.

Genevestigator

Q9ZVN4.

GermOnline

AT1G05000. Arabidopsis thaliana.

Family and domain databases

InterPro

IPR016130. Tyr_Pase_AS.
IPR020428. Tyr_Pase_dualsp-Pase_euk.
IPR004861. Tyr_Pase_SIW14-like.
[Graphical view]

Pfam

PF03162. Y_phosphatase2. 1 hit.
[Graphical view]

PRINTS

PR01911. PFDSPHPHTASE.

PROSITE

PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. False negative.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9ZVN4.

Entry information

Entry name

Y1500_ARATH

Accession

Primary (citable) accession number: Q9ZVN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program