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Q9ZVN4

- Y1500_ARATH

UniProt

Q9ZVN4 - Y1500_ARATH

Protein

Probable tyrosine-protein phosphatase At1g05000

Gene

At1g05000

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei150 – 1501Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciARA:GQT-352-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable tyrosine-protein phosphatase At1g05000 (EC:3.1.3.48)
    Gene namesi
    Ordered Locus Names:At1g05000
    ORF Names:T7A14.14
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G05000.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Probable tyrosine-protein phosphatase At1g05000PRO_0000094923Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZVN4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ZVN4.
    GenevestigatoriQ9ZVN4.

    Interactioni

    Subunit structurei

    Homomultimer.Curated

    Protein-protein interaction databases

    BioGridi24583. 17 interactions.

    Structurei

    Secondary structure

    1
    215
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi60 – 634
    Beta strandi66 – 705
    Helixi74 – 8310
    Beta strandi86 – 905
    Helixi98 – 10710
    Beta strandi110 – 1134
    Helixi121 – 1233
    Helixi128 – 13912
    Helixi141 – 1433
    Beta strandi145 – 1495
    Beta strandi151 – 1555
    Helixi156 – 16712
    Helixi172 – 18312
    Helixi184 – 1863
    Helixi189 – 1968

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XRIX-ray3.30A/B52-202[»]
    2Q47X-ray3.30A/B52-202[»]
    ProteinModelPortaliQ9ZVN4.
    SMRiQ9ZVN4. Positions 52-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ZVN4.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 104Poly-Thr

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2365.
    HOGENOMiHOG000188365.
    InParanoidiQ9ZVN4.
    KOiK18045.
    PhylomeDBiQ9ZVN4.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR020428. Tyr_Pase_dualsp-Pase_euk.
    IPR004861. Tyr_Pase_SIW14-like.
    [Graphical view]
    PfamiPF03162. Y_phosphatase2. 1 hit.
    [Graphical view]
    PRINTSiPR01911. PFDSPHPHTASE.
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9ZVN4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLVEKTTTT EQDNGEDFCR TIIEVSEVNR NVFQAPGGEA DPFRVVSGEE    50
    LHLIPPLNFS MVDNGIFRSG FPDSANFSFL QTLGLRSIIY LCPEPYPESN 100
    LQFLKSNGIR LFQFGIEGNK EPFVNIPDHK IRMALKVLLD EKNHPVLIHC 150
    KRGKHRTGCL VGCLRKLQKW CLTSIFDEYQ RFAAAKARVS DQRFMEIFDV 200
    SSFSHIPMSF SCSIR 215
    Length:215
    Mass (Da):24,537
    Last modified:May 1, 1999 - v1
    Checksum:i24BCB3033CBCFA3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005322 Genomic DNA. Translation: AAC97999.1.
    CP002684 Genomic DNA. Translation: AEE27777.1.
    BT005210 mRNA. Translation: AAO63274.1.
    PIRiG86183.
    RefSeqiNP_171993.1. NM_100379.2. [Q9ZVN4-1]
    UniGeneiAt.43231.

    Genome annotation databases

    EnsemblPlantsiAT1G05000.1; AT1G05000.1; AT1G05000. [Q9ZVN4-1]
    GeneIDi839348.
    KEGGiath:AT1G05000.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005322 Genomic DNA. Translation: AAC97999.1 .
    CP002684 Genomic DNA. Translation: AEE27777.1 .
    BT005210 mRNA. Translation: AAO63274.1 .
    PIRi G86183.
    RefSeqi NP_171993.1. NM_100379.2. [Q9ZVN4-1 ]
    UniGenei At.43231.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XRI X-ray 3.30 A/B 52-202 [» ]
    2Q47 X-ray 3.30 A/B 52-202 [» ]
    ProteinModelPortali Q9ZVN4.
    SMRi Q9ZVN4. Positions 52-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 24583. 17 interactions.

    Proteomic databases

    PRIDEi Q9ZVN4.

    Protocols and materials databases

    DNASUi 839348.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G05000.1 ; AT1G05000.1 ; AT1G05000 . [Q9ZVN4-1 ]
    GeneIDi 839348.
    KEGGi ath:AT1G05000.

    Organism-specific databases

    TAIRi AT1G05000.

    Phylogenomic databases

    eggNOGi COG2365.
    HOGENOMi HOG000188365.
    InParanoidi Q9ZVN4.
    KOi K18045.
    PhylomeDBi Q9ZVN4.

    Enzyme and pathway databases

    BioCyci ARA:GQT-352-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9ZVN4.

    Gene expression databases

    ArrayExpressi Q9ZVN4.
    Genevestigatori Q9ZVN4.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR020428. Tyr_Pase_dualsp-Pase_euk.
    IPR004861. Tyr_Pase_SIW14-like.
    [Graphical view ]
    Pfami PF03162. Y_phosphatase2. 1 hit.
    [Graphical view ]
    PRINTSi PR01911. PFDSPHPHTASE.
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "X-ray structure of a putative phosphoprotein phosphatase from Arabidopsis thaliana gene At1g05000."
      Center for eukaryotic structural genomics (CESG)
      Submitted (FEB-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 52-202.

    Entry informationi

    Entry nameiY1500_ARATH
    AccessioniPrimary (citable) accession number: Q9ZVN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3