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Protein

Annexin D4

Gene

ANN4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in osmotic stress and abscisic acid signaling in a calcium-dependent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

  • response to abscisic acid Source: TAIR
  • response to cold Source: TAIR
  • response to heat Source: TAIR
  • response to osmotic stress Source: TAIR
  • response to salt stress Source: TAIR
  • response to water deprivation Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin D4
Alternative name(s):
AnnAt4
Gene namesi
Name:ANN4
Synonyms:ANNAT4
Ordered Locus Names:At2g38750
ORF Names:T6A23.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G38750.

Subcellular locationi

GO - Cellular componenti

  • plasmodesma Source: TAIR
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Plants are hypersensitive to osmotic stress and abscisic acid (ABA) during germination and early seedling growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Annexin D4PRO_0000278818Add
BLAST

Proteomic databases

PaxDbiQ9ZVJ6.
PRIDEiQ9ZVJ6.

PTM databases

iPTMnetiQ9ZVJ6.

Expressioni

Tissue specificityi

Expressed mainly in roots and flowers. Lower in stems and leaves.1 Publication

Inductioni

Up-regulated by salt, osmotic and oxidative stresses. Up-regulated by abscisic acid (ABA) and salicylic acid (SA). Down-regulated by heat shock and dehydration stresses.2 Publications

Gene expression databases

GenevisibleiQ9ZVJ6. AT.

Interactioni

Protein-protein interaction databases

BioGridi3799. 10 interactions.
IntActiQ9ZVJ6. 7 interactions.
STRINGi3702.AT2G38750.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZVJ6.
SMRiQ9ZVJ6. Positions 3-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati90 – 15566Annexin 1Add
BLAST
Repeati173 – 23967Annexin 2Add
BLAST
Repeati245 – 31470Annexin 3Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Contains 3 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158802.
InParanoidiQ9ZVJ6.
OMAiVAYRAKD.
PhylomeDBiQ9ZVJ6.

Family and domain databases

Gene3Di1.10.220.10. 3 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
[Graphical view]
PfamiPF00191. Annexin. 3 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLELESL TEAISAGMGM GVDENALIST LGKSQKEHRK LFRKASKSFF
60 70 80 90 100
VEDEERAFEK CHDHFVRHLK LEFSRFNTAV VMWAMHPWER DARLVKKALK
110 120 130 140 150
KGEEAYNLIV EVSCTRSAED LLGARKAYHS LFDQSMEEDI ASHVHGPQRK
160 170 180 190 200
LLVGLVSAYR YEGNKVKDDS AKSDAKILAE AVASSGEEAV EKDEVVRILT
210 220 230 240 250
TRSKLHLQHL YKHFNEIKGS DLLGGVSKSS LLNEALICLL KPALYFSKIL
260 270 280 290 300
DASLNKDADK TTKKWLTRVF VTRADHSDEM NEIKEEYNNL YGETLAQRIQ
310
EKIKGNYRDF LLTLLSKSD
Length:319
Mass (Da):36,221
Last modified:May 1, 1999 - v1
Checksum:i06E38E2FA513017E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188363 mRNA. Translation: AAF14581.1.
AC005499 Genomic DNA. Translation: AAC67343.1.
CP002685 Genomic DNA. Translation: AEC09580.1.
AY087194 mRNA. Translation: AAM64750.1.
AY042835 mRNA. Translation: AAK68775.1.
AY081483 mRNA. Translation: AAM10045.1.
PIRiH84808.
RefSeqiNP_181409.1. NM_129432.2.
UniGeneiAt.20551.

Genome annotation databases

EnsemblPlantsiAT2G38750.1; AT2G38750.1; AT2G38750.
GeneIDi818457.
GrameneiAT2G38750.1; AT2G38750.1; AT2G38750.
KEGGiath:AT2G38750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188363 mRNA. Translation: AAF14581.1.
AC005499 Genomic DNA. Translation: AAC67343.1.
CP002685 Genomic DNA. Translation: AEC09580.1.
AY087194 mRNA. Translation: AAM64750.1.
AY042835 mRNA. Translation: AAK68775.1.
AY081483 mRNA. Translation: AAM10045.1.
PIRiH84808.
RefSeqiNP_181409.1. NM_129432.2.
UniGeneiAt.20551.

3D structure databases

ProteinModelPortaliQ9ZVJ6.
SMRiQ9ZVJ6. Positions 3-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3799. 10 interactions.
IntActiQ9ZVJ6. 7 interactions.
STRINGi3702.AT2G38750.1.

PTM databases

iPTMnetiQ9ZVJ6.

Proteomic databases

PaxDbiQ9ZVJ6.
PRIDEiQ9ZVJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G38750.1; AT2G38750.1; AT2G38750.
GeneIDi818457.
GrameneiAT2G38750.1; AT2G38750.1; AT2G38750.
KEGGiath:AT2G38750.

Organism-specific databases

TAIRiAT2G38750.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158802.
InParanoidiQ9ZVJ6.
OMAiVAYRAKD.
PhylomeDBiQ9ZVJ6.

Miscellaneous databases

PROiQ9ZVJ6.

Gene expression databases

GenevisibleiQ9ZVJ6. AT.

Family and domain databases

Gene3Di1.10.220.10. 3 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
[Graphical view]
PfamiPF00191. Annexin. 3 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of two novel Arabidopsis annexin cDNAs."
    Clark G.B., Rives A.E., Beauchamp L.M., Roux S.J.
    Plant Gene Register PGR99-168
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Differential expression of members of the annexin multigene family in Arabidopsis."
    Clark G.B., Sessions A., Eastburn D.J., Roux S.J.
    Plant Physiol. 126:1072-1084(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Proteomic identification of annexins, calcium-dependent membrane binding proteins that mediate osmotic stress and abscisic acid signal transduction in Arabidopsis."
    Lee S., Lee E.J., Yang E.J., Lee J.E., Park A.R., Song W.H., Park O.K.
    Plant Cell 16:1378-1391(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  8. "Expression profiling of the Arabidopsis annexin gene family during germination, de-etiolation and abiotic stress."
    Cantero A., Barthakur S., Bushart T.J., Chou S., Morgan R.O., Fernandez M.P., Clark G.B., Roux S.J.
    Plant Physiol. Biochem. 44:13-24(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, GENE FAMILY.

Entry informationi

Entry nameiANXD4_ARATH
AccessioniPrimary (citable) accession number: Q9ZVJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.