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Protein

Annexin D4

Gene

ANN4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in osmotic stress and abscisic acid signaling in a calcium-dependent manner.1 Publication

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro
  • mRNA binding Source: TAIR

GO - Biological processi

  • response to abscisic acid Source: TAIR
  • response to cold Source: TAIR
  • response to heat Source: TAIR
  • response to osmotic stress Source: TAIR
  • response to salt stress Source: TAIR
  • response to water deprivation Source: TAIR

Keywordsi

Biological processStress response
LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-ATH-114608 Platelet degranulation
R-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin D4
Alternative name(s):
AnnAt4
Gene namesi
Name:ANN4
Synonyms:ANNAT4
Ordered Locus Names:At2g38750
ORF Names:T6A23.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G38750
TAIRilocus:2064222 AT2G38750

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Plants are hypersensitive to osmotic stress and abscisic acid (ABA) during germination and early seedling growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002788181 – 319Annexin D4Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphothreonineBy similarity1
Modified residuei159PhosphotyrosineBy similarity1
Modified residuei211Phosphotyrosine1 Publication1
Modified residuei277Phosphoserine1 Publication1
Modified residuei287PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZVJ6
PRIDEiQ9ZVJ6

PTM databases

iPTMnetiQ9ZVJ6

Expressioni

Tissue specificityi

Expressed mainly in roots and flowers. Lower in stems and leaves.1 Publication

Inductioni

Up-regulated by salt, osmotic and oxidative stresses. Up-regulated by abscisic acid (ABA) and salicylic acid (SA). Down-regulated by heat shock and dehydration stresses.2 Publications

Gene expression databases

ExpressionAtlasiQ9ZVJ6 baseline and differential
GenevisibleiQ9ZVJ6 AT

Interactioni

Protein-protein interaction databases

BioGridi3799, 10 interactors
IntActiQ9ZVJ6, 7 interactors
MINTiQ9ZVJ6
STRINGi3702.AT2G38750.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZVJ6
SMRiQ9ZVJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati90 – 155Annexin 1Add BLAST66
Repeati173 – 239Annexin 2Add BLAST67
Repeati245 – 314Annexin 3Add BLAST70

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
HOGENOMiHOG000158802
InParanoidiQ9ZVJ6
KOiK17098
OMAiDALDSEC
OrthoDBiEOG09360GXW
PhylomeDBiQ9ZVJ6

Family and domain databases

Gene3Di1.10.220.10, 3 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR037104 Annexin_sf
PfamiView protein in Pfam
PF00191 Annexin, 3 hits
PRINTSiPR00196 ANNEXIN
SMARTiView protein in SMART
SM00335 ANX, 2 hits

Sequencei

Sequence statusi: Complete.

Q9ZVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLELESL TEAISAGMGM GVDENALIST LGKSQKEHRK LFRKASKSFF
60 70 80 90 100
VEDEERAFEK CHDHFVRHLK LEFSRFNTAV VMWAMHPWER DARLVKKALK
110 120 130 140 150
KGEEAYNLIV EVSCTRSAED LLGARKAYHS LFDQSMEEDI ASHVHGPQRK
160 170 180 190 200
LLVGLVSAYR YEGNKVKDDS AKSDAKILAE AVASSGEEAV EKDEVVRILT
210 220 230 240 250
TRSKLHLQHL YKHFNEIKGS DLLGGVSKSS LLNEALICLL KPALYFSKIL
260 270 280 290 300
DASLNKDADK TTKKWLTRVF VTRADHSDEM NEIKEEYNNL YGETLAQRIQ
310
EKIKGNYRDF LLTLLSKSD
Length:319
Mass (Da):36,221
Last modified:May 1, 1999 - v1
Checksum:i06E38E2FA513017E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188363 mRNA Translation: AAF14581.1
AC005499 Genomic DNA Translation: AAC67343.1
CP002685 Genomic DNA Translation: AEC09580.1
AY087194 mRNA Translation: AAM64750.1
AY042835 mRNA Translation: AAK68775.1
AY081483 mRNA Translation: AAM10045.1
PIRiH84808
RefSeqiNP_181409.1, NM_129432.3
UniGeneiAt.20551

Genome annotation databases

EnsemblPlantsiAT2G38750.1; AT2G38750.1; AT2G38750
GeneIDi818457
GrameneiAT2G38750.1; AT2G38750.1; AT2G38750
KEGGiath:AT2G38750

Similar proteinsi

Entry informationi

Entry nameiANXD4_ARATH
AccessioniPrimary (citable) accession number: Q9ZVJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health