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Q9ZVC2

- NPR5_ARATH

UniProt

Q9ZVC2 - NPR5_ARATH

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Protein
Regulatory protein NPR5
Gene
NPR5, BOP2, At2g41370, F13H10.8
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB, YAB1/FIL and YAB3, and through positive regulation of LOB domain-containing genes LOB, LBD6/AS2 and LBD36. Promotes and maintains a developmentally determinate state in leaf cells through the negative regulation of JAG, JGL and class I KNOX genes. Is also involved in nectary development, formation of normal abscission zones and suppression of bract formation.7 Publications

Pathwayi

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. bract formation Source: UniProtKB
  2. floral meristem determinacy Source: TAIR
  3. floral organ abscission Source: UniProtKB
  4. flower morphogenesis Source: TAIR
  5. induced systemic resistance, jasmonic acid mediated signaling pathway Source: TAIR
  6. nectary development Source: TAIR
  7. polarity specification of adaxial/abaxial axis Source: TAIR
  8. protein ubiquitination Source: UniProtKB-UniPathway
  9. proximal/distal pattern formation Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein NPR5
Alternative name(s):
BTB/POZ domain-containing protein NPR5
Protein BLADE ON PETIOLE 2
Gene namesi
Name:NPR5
Synonyms:BOP2
Ordered Locus Names:At2g41370
ORF Names:F13H10.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G41370.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Defects in inflorescence and flower development. Bop1 and bop2 double mutant displays leafy petioles, loss of floral organ abscission, and asymmetric flowers subtended by a bract.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Regulatory protein NPR5
PRO_0000407994Add
BLAST

Proteomic databases

PaxDbiQ9ZVC2.
PRIDEiQ9ZVC2.

Expressioni

Tissue specificityi

Highly expressed in young floral meristem.1 Publication

Developmental stagei

Expressed during vegetative development in young leaf primordia and at the base of the rosette leaves on the adaxial side. Expressed during reproductive development in young floral buds, and at the base of the sepals and petals.1 Publication

Gene expression databases

GenevestigatoriQ9ZVC2.

Interactioni

Subunit structurei

Homodimer or heterodimer with BOP1. Interacts with PAN.2 Publications

Protein-protein interaction databases

BioGridi4072. 5 interactions.
IntActiQ9ZVC2. 4 interactions.
STRINGi3702.AT2G41370.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZVC2.
SMRiQ9ZVC2. Positions 203-423.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 11691BTB
Add
BLAST
Repeati254 – 28330ANK 1
Add
BLAST
Repeati284 – 31330ANK 2
Add
BLAST
Repeati318 – 34730ANK 3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi403 – 43533Asn-rich
Add
BLAST
Compositional biasi472 – 49019His-rich
Add
BLAST

Domaini

The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.1 Publication

Sequence similaritiesi

Contains 3 ANK repeats.
Contains 1 BTB (POZ) domain.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG298720.
HOGENOMiHOG000234377.
InParanoidiQ9ZVC2.
KOiK14508.
OMAiHYAVESC.
PhylomeDBiQ9ZVC2.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR024228. DUF3420.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF00651. BTB. 1 hit.
PF11900. DUF3420. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZVC2-1 [UniParc]FASTAAdd to Basket

« Hide

MSNLEESLRS LSLDFLNLLI NGQAFSDVTF SVEGRLVHAH RCILAARSLF    50
FRKFFCGTDS PQPVTGIDPT QHGSVPASPT RGSTAPAGII PVNSVGYEVF 100
LLLLQFLYSG QVSIVPQKHE PRPNCGERGC WHTHCSAAVD LALDTLAASR 150
YFGVEQLALL TQKQLASMVE KASIEDVMKV LIASRKQDMH QLWTTCSHLV 200
AKSGLPPEIL AKHLPIDVVT KIEELRLKSS IARRSLMPHN HHHDLSVAQD 250
LEDQKIRRMR RALDSSDVEL VKLMVMGEGL NLDESLALHY AVESCSREVV 300
KALLELGAAD VNYPAGPAGK TPLHIAAEMV SPDMVAVLLD HHADPNVRTV 350
GGITPLDILR TLTSDFLFKG AVPGLTHIEP NKLRLCLELV QSAAMVISRE 400
EGNNSNNQNN DNNTGIYPHM NEEHNSGSSG GSNNNLDSRL VYLNLGAGTG 450
QMGPGRDQGD DHNSQREGMS RHHHHHQDPS TMYHHHHQHH F 491
Length:491
Mass (Da):54,001
Last modified:May 1, 1999 - v1
Checksum:iF2E8A7133B591776
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861C → R in AAO22795. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY928830 mRNA. Translation: AAX22759.1.
AC005662 Genomic DNA. Translation: AAC78536.1.
CP002685 Genomic DNA. Translation: AEC09966.1.
BT002986 mRNA. Translation: AAO22795.1.
BT015773 mRNA. Translation: AAU90063.1.
PIRiH84840.
RefSeqiNP_181668.1. NM_129700.2.
UniGeneiAt.43967.

Genome annotation databases

EnsemblPlantsiAT2G41370.1; AT2G41370.1; AT2G41370.
GeneIDi818735.
KEGGiath:AT2G41370.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY928830 mRNA. Translation: AAX22759.1 .
AC005662 Genomic DNA. Translation: AAC78536.1 .
CP002685 Genomic DNA. Translation: AEC09966.1 .
BT002986 mRNA. Translation: AAO22795.1 .
BT015773 mRNA. Translation: AAU90063.1 .
PIRi H84840.
RefSeqi NP_181668.1. NM_129700.2.
UniGenei At.43967.

3D structure databases

ProteinModelPortali Q9ZVC2.
SMRi Q9ZVC2. Positions 203-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 4072. 5 interactions.
IntActi Q9ZVC2. 4 interactions.
STRINGi 3702.AT2G41370.1-P.

Proteomic databases

PaxDbi Q9ZVC2.
PRIDEi Q9ZVC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G41370.1 ; AT2G41370.1 ; AT2G41370 .
GeneIDi 818735.
KEGGi ath:AT2G41370.

Organism-specific databases

TAIRi AT2G41370.

Phylogenomic databases

eggNOGi NOG298720.
HOGENOMi HOG000234377.
InParanoidi Q9ZVC2.
KOi K14508.
OMAi HYAVESC.
PhylomeDBi Q9ZVC2.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Gene expression databases

Genevestigatori Q9ZVC2.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR024228. DUF3420.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF00651. BTB. 1 hit.
PF11900. DUF3420. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis."
    Hepworth S.R., Zhang Y., McKim S., Li X., Haughn G.W.
    Plant Cell 17:1434-1448(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH PAN.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis ORF clones."
    Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "The BLADE ON PETIOLE genes act redundantly to control the growth and development of lateral organs."
    Norberg M., Holmlund M., Nilsson O.
    Development 132:2203-2213(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  7. "Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis."
    Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L., Vierstra R.D.
    J. Biol. Chem. 280:18810-18821(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN BTB.
  8. "An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance."
    Liu G., Holub E.B., Alonso J.M., Ecker J.R., Fobert P.R.
    Plant J. 41:304-318(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  9. "BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes."
    Ha C.M., Jun J.H., Nam H.G., Fletcher J.C.
    Plant Cell 19:1809-1825(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  10. "The BLADE-ON-PETIOLE genes are essential for abscission zone formation in Arabidopsis."
    McKim S.M., Stenvik G.E., Butenko M.A., Kristiansen W., Cho S.K., Hepworth S.R., Aalen R.B., Haughn G.W.
    Development 135:1537-1546(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  11. "Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors."
    Ha C.M., Jun J.H., Fletcher J.C.
    Genetics 186:197-206(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "BLADE-ON-PETIOLE1 coordinates organ determinacy and axial polarity in arabidopsis by directly activating ASYMMETRIC LEAVES2."
    Jun J.H., Ha C.M., Fletcher J.C.
    Plant Cell 22:62-76(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  13. "Arabidopsis BLADE-ON-PETIOLE1 and 2 promote floral meristem fate and determinacy in a previously undefined pathway targeting APETALA1 and AGAMOUS-LIKE24."
    Xu M., Hu T., McKim S.M., Murmu J., Haughn G.W., Hepworth S.R.
    Plant J. 63:974-989(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNPR5_ARATH
AccessioniPrimary (citable) accession number: Q9ZVC2
Secondary accession number(s): Q84WN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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