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Q9ZV25 (P2C23_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 23

Short name=AtPP2C23
EC=3.1.3.16
Alternative name(s):
Protein POLTERGEIST-LIKE 4
Protein phosphatase 2C PLL4
Short name=PP2C PLL4
Gene names
Name:PLL4
Ordered Locus Names:At2g28890
ORF Names:F8N16.18
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in leaf development regulation. Ref.4

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in seedlings, roots, leaves, stems, young inflorescences, flowers and siliques. Ref.4

Domain

The conserved PP2C phosphatase domain (244-643) is interrupted by an insertion of approximately 100 amino acids.

Disruption phenotype

Plants show abnormal leaves altered in shape and curling. Ref.4

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionDevelopmental protein
Hydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleaf development

Inferred from mutant phenotype Ref.4. Source: TAIR

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay PubMed 17317660. Source: TAIR

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 654654Probable protein phosphatase 2C 23
PRO_0000301262

Regions

Domain311 – 621311PP2C-like

Sites

Metal binding2801Manganese 1 By similarity
Metal binding2801Manganese 2 By similarity
Metal binding2811Manganese 1; via carbonyl oxygen By similarity
Metal binding5731Manganese 2 By similarity
Metal binding6361Manganese 2 By similarity

Amino acid modifications

Modified residue1471Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZV25 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6EEE6628C5AA060A

FASTA65472,482
        10         20         30         40         50         60 
MGNGIGKLSK CLTGGAGRNK KPELSILEPD PLDEGLGHSF CYVRPDPTRV SSSKVHSEEE 

        70         80         90        100        110        120 
TTTFRTISGA SVSANTATPL STSLYDPYGH IDRAAAFEST TSFSSIPLQP IPRSSGPIVP 

       130        140        150        160        170        180 
GSGPLERGFL SGPIERGFMS GPLDGSSGPI DGKTGSDQFQ RSFSHGLANL RVGSRKGSLV 

       190        200        210        220        230        240 
RVLRRAISKT ITRGQNSIVA PIKPVKEPDW VFGSDKTRIH QIENNLTVNS LNFSSEGSLL 

       250        260        270        280        290        300 
DDDVSLESQN LQWAQGKAGE DRVHVVVSEE HGWLFVGIYD GFNGPDAPDY LLSHLYPAVH 

       310        320        330        340        350        360 
RELKGLLWDD PKTDAKSSDE ADVENRDSSS EKKSKNWEES QRRWRCEWDR DLDRLLKDRS 

       370        380        390        400        410        420 
NGLDLDPDPN SSDVLKALSQ ALRKTEEAYL ENADMMLDEN PELALMGSCV LVMLMKGEDV 

       430        440        450        460        470        480 
YLMNVGDSRA VLGQKAESDY WIGKIKQDLE RINEETMNDF DGCGDGEGAS LVPTLSAFQL 

       490        500        510        520        530        540 
TVDHSTNVEE EVNRIRKEHP DDASAVSNER VKGSLKVTRA FGAGFLKQPK WNNALLEMFQ 

       550        560        570        580        590        600 
IDYKGTSPYI NCLPSLYHHR LGSKDQFLIL SSDGLYQYFT NEEAVSEVEL FITLQPEGDP 

       610        620        630        640        650 
AQHLVQELLF RAAKKAGMDF HELLEIPQGE RRRYHDDVSI VVISLEGRMW KSCV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"POL and related phosphatases are dosage-sensitive regulators of meristem and organ development in Arabidopsis."
Song S.-K., Clark S.E.
Dev. Biol. 285:272-284(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE, DISRUPTION PHENOTYPE.
[5]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005727 Genomic DNA. Translation: AAC79593.1.
CP002685 Genomic DNA. Translation: AEC08185.1.
AY065299 mRNA. Translation: AAL38775.1.
AY096450 mRNA. Translation: AAM20090.1.
PIRB84690.
RefSeqNP_180455.1. NM_128448.3.
UniGeneAt.27597.

3D structure databases

ProteinModelPortalQ9ZV25.
SMRQ9ZV25. Positions 403-645.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT2G28890.1-P.

Proteomic databases

PaxDbQ9ZV25.
PRIDEQ9ZV25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G28890.1; AT2G28890.1; AT2G28890.
GeneID817438.
KEGGath:AT2G28890.

Organism-specific databases

TAIRAT2G28890.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000239375.
InParanoidQ9ZV25.
OMARRWRCEW.
PhylomeDBQ9ZV25.

Enzyme and pathway databases

BioCycARA:AT2G28890-MONOMER.

Gene expression databases

GenevestigatorQ9ZV25.

Family and domain databases

Gene3D3.60.40.10. 3 hits.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 3 hits.
ProtoNetSearch...

Entry information

Entry nameP2C23_ARATH
AccessionPrimary (citable) accession number: Q9ZV25
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names