Q9ZV04 (PER24_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxidase 24
Short name=Atperox P24
EC=1.11.1.7

Alternative name(s):
ATP47

Gene names

Name:	PER24
Synonyms:	P24
Ordered Locus Names:	At2g39040
ORF Names:	T7F6.21

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Catalytic activity	2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity. Binds 2 calcium ions per subunit By similarity.
Subcellular location	Secreted By similarity.
Induction	Up-regulated transiently by a cold treatment. Ref.4
Miscellaneous	There are 73 peroxidase genes in A.thaliana.
Sequence similarities	Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 350	323	Peroxidase 24		PRO_0000023690
Sites
	Active site	86	1	Proton acceptor
	Metal binding	87	1	Calcium 1 By similarity
	Metal binding	90	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	92	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	94	1	Calcium 1 By similarity
	Metal binding	96	1	Calcium 1 By similarity
	Metal binding	214	1	Iron (heme axial ligand) By similarity
	Metal binding	215	1	Calcium 2 By similarity
	Metal binding	269	1	Calcium 2 By similarity
	Metal binding	277	1	Calcium 2 By similarity
	Binding site	184	1	Substrate; via carbonyl oxygen By similarity
	Site	82	1	Transition state stabilizer By similarity
Amino acid modifications
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	230	1	N-linked (GlcNAc...) Potential
	Disulfide bond	55 ↔ 135		By similarity
	Disulfide bond	88 ↔ 93		By similarity
	Disulfide bond	141 ↔ 346		By similarity
	Disulfide bond	221 ↔ 253		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZV04 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C230E2368D2C5D08	FASTA	350	38,237
	10 20 30 40 50 60 MANKSLEIRF LFPLVLFLVV KLLCVDGKGF NNNGHKIRKG RWEGKLKMNF YHNSCPGAED 70 80 90 100 110 120 IVRQIVWKKV EANRSLAPKL LRVHYHDCFV RGCDASLLLD SVAGKAVSEK EARPNLSLSG 130 140 150 160 170 180 FEIIDEIKYI LEKRCPNTVS CADILTLAAR DAVSYEFERP LWNVFTGRVD GRVSLATEAA 190 200 210 220 230 240 RDLPSAGANF TTLQKLFAES DLDVVDLVAL SGAHTIGIAH CGVFGRRLLN FTGKGDTDPS 250 260 270 280 290 300 LNPSYASFLK SECSDKSLRL NPSAVVGMDP TGPLAFDSGY FVSLLKNKGL FTSDAALLTD 310 320 330 340 350 PSAAHIASVF QNSGAFLAQF GRSMIKMSSI KVLTLGDQGG EIRKNCRLVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Arabidopsis ORF clones." Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway." Fowler S., Thomashow M.F. Plant Cell 14:1675-1690(2002) [PubMed: 12172015] [Abstract] Cited for: INDUCTION. Strain: cv. Columbia.
[5]	"Analysis and expression of the class III peroxidase large gene family in Arabidopsis thaliana." Tognolli M., Penel C., Greppin H., Simon P. Gene 288:129-138(2002) [PubMed: 12034502] [Abstract] Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005770 Genomic DNA. Translation: AAC79614.1. CP002685 Genomic DNA. Translation: AEC09629.1. BT026452 mRNA. Translation: ABH04559.1.
IPI	IPI00540929.
PIR	D84812.
RefSeq	NP_181437.1. NM_129461.2.
UniGene	At.37216.
3D structure databases
ProteinModelPortal	Q9ZV04.
SMR	Q9ZV04. Positions 45-350.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZV04.
Protein family/group databases
PeroxiBase	117. AtPrx24.
Proteomic databases
PRIDE	Q9ZV04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G39040.1; AT2G39040.1; AT2G39040.
GeneID	818490.
GenomeReviews	Gene locus AT2G39040 in contig CT485783_GR.
KEGG	ath:AT2G39040.
NMPDR	fig|3702.1.peg.11019.
Organism-specific databases
GeneFarm	1849. 61.
TAIR	At2g39040.
Phylogenomic databases
GeneTree	EPGT00050000003675.
HOGENOM	HBG597790.
InParanoid	Q9ZV04.
OMA	PSAGANF.
PhylomeDB	Q9ZV04.
ProtClustDB	CLSN2912987.
Gene expression databases
Genevestigator	Q9ZV04.
GermOnline	AT2G39040. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR000823. Peroxidase_pln. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
KO	K00430.
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00458. PEROXIDASE. PR00461. PLPEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. False negative. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PER24_ARATH

Accession

Primary (citable) accession number: Q9ZV04
Secondary accession number(s): Q0V7W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	May 1, 1999
Last modified:	December 14, 2011
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program