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Q9ZUV3 (IRX7_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucuronoxylan glucuronosyltransferase IRX7

EC=2.4.1.-
Alternative name(s):
Protein FRAGILE FIBER 8
Protein IRREGULAR XYLEM 7
Gene names
Name:IRX7
Synonyms:FRA8
Ordered Locus Names:At2g28110
ORF Names:F24D13.10
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the synthesis of the glycosyl sequence at the glucuronoxylan reducing end. Ref.1 Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Probable Ref.1.

Tissue specificity

Expressed in developing interfascicular fibers and xylem cells in stems and developing secondary xylem in roots. Ref.1

Disruption phenotype

Dwarf phenotype. Strong reduction of secondary wall thickness, collapsed xylem vessels and reduced xylan content in cell wall. Ref.1 Ref.5 Ref.8

Sequence similarities

Belongs to the glycosyltransferase 47 family.

Sequence caution

The sequence AAL91236.1 differs from that shown. Reason: Frameshift at position 215.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glucuronoxylan glucuronosyltransferase IRX7
PRO_0000407574

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain38 – 448411Lumenal Potential

Amino acid modifications

Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation2871N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZUV3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 0C71F7FDD8F0C425

FASTA44851,694
        10         20         30         40         50         60 
MTTHKHRRTE KNLCFKQYYK WILCFILTLY FFASFFVDHD QDHRSSTSIS KHLLTNHKPK 

        70         80         90        100        110        120 
LFASRAMFES KIHDHKLGFT SQQPNIKTDV FNNLKIYVYD LPSKFNKDWL ANDRCTNHLF 

       130        140        150        160        170        180 
AAEVALHKAF LSLEGDVRTE DPYEADFFFV PVYVSCNFST INGFPAIGHA RSLINDAIKL 

       190        200        210        220        230        240 
VSTQYPFWNR TSGSDHVFTA THDFGSCFHT MEDRAIADGV PIFLRNSIIL QTFGVTFNHP 

       250        260        270        280        290        300 
CQEVENVVIP PYISPESLHK TQKNIPVTKE RDIWVFFRGK MELHPKNISG RFYSKRVRTN 

       310        320        330        340        350        360 
IWRSYGGDRR FYLQRQRFAG YQSEIARSVF CLCPLGWAPW SPRLVESVAL GCVPVIIADG 

       370        380        390        400        410        420 
IRLPFPSTVR WPDISLTVAE RDVGKLGDIL EHVAATNLSV IQRNLEDPSV RRALMFNVPS 

       430        440 
REGDATWQVL EALSKKLNRS VRRSNSFL 

« Hide

References

« Hide 'large scale' references
[1]"Arabidopsis fragile fiber8, which encodes a putative glucuronyltransferase, is essential for normal secondary wall synthesis."
Zhong R., Pena M.J., Zhou G.K., Nairn C.J., Wood-Jones A., Richardson E.A., Morrison W.H. III, Darvill A.G., York W.S., Ye Z.H.
Plant Cell 17:3390-3408(2005) [PubMed: 16272433] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed: 10617197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics."
Brown D.M., Zeef L.A.H., Ellis J., Goodacre R., Turner S.R.
Plant Cell 17:2281-2295(2005) [PubMed: 15980264] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[6]"The irregular xylem9 mutant is deficient in xylan xylosyltransferase activity."
Lee C., O'Neill M.A., Tsumuraya Y., Darvill A.G., Ye Z.H.
Plant Cell Physiol. 48:1624-1634(2007) [PubMed: 17938130] [Abstract]
Cited for: FUNCTION.
[7]"The PARVUS gene is expressed in cells undergoing secondary wall thickening and is essential for glucuronoxylan biosynthesis."
Lee C., Zhong R., Richardson E.A., Himmelsbach D.S., McPhail B.T., Ye Z.H.
Plant Cell Physiol. 48:1659-1672(2007) [PubMed: 17991630] [Abstract]
Cited for: FUNCTION.
[8]"Comparison of five xylan synthesis mutants reveals new insight into the mechanisms of xylan synthesis."
Brown D.M., Goubet F., Wong V.W., Goodacre R., Stephens E., Dupree P., Turner S.R.
Plant J. 52:1154-1168(2007) [PubMed: 17944810] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ182567 mRNA. Translation: ABA60868.1.
DQ182568 Genomic DNA. Translation: ABA60869.1.
AC005851 Genomic DNA. Translation: AAC98455.1.
CP002685 Genomic DNA. Translation: AEC08081.1.
AY081347 mRNA. Translation: AAL91236.1. Frameshift.
BT006256 mRNA. Translation: AAP13364.1.
IPIIPI00528947.
PIRH84680.
RefSeqNP_850113.2. NM_179782.3.
UniGeneAt.38661.

3D structure databases

ProteinModelPortalQ9ZUV3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ZUV3.

Protein family/group databases

CAZyGT47. Glycosyltransferase Family 47.

Proteomic databases

PRIDEQ9ZUV3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G28110.1; AT2G28110.1; AT2G28110.
GeneID817357.
GenomeReviewsGene locus AT2G28110 in contig CT485783_GR.
KEGGath:AT2G28110.
NMPDRfig|3702.1.peg.9860.

Organism-specific databases

TAIRAt2g28110.

Phylogenomic databases

GeneTreeEPGT00070000030424.
InParanoidQ9ZUV3.
OMAVIPPYIS.
PhylomeDBQ9ZUV3.
ProtClustDBCLSN2681061.

Gene expression databases

GenevestigatorQ9ZUV3.

Family and domain databases

InterProIPR004263. Exostosin.
[Graphical view]
PfamPF03016. Exostosin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIRX7_ARATH
AccessionPrimary (citable) accession number: Q9ZUV3
Secondary accession number(s): Q8RXC5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 1, 1999
Last modified: December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families