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Protein

Vacuolar iron transporter 1

Gene

VIT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Vacuolar iron transporter involved in the transfer of iron from the cytosol to the vacuole for intracellular iron storage. Vacuolar iron storage is required for seed embryo and seedling development.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular manganese ion homeostasis Source: GO_Central
  • cellular response to iron ion Source: GO_Central
  • intracellular sequestering of iron ion Source: TAIR
  • iron ion homeostasis Source: TAIR
  • manganese ion transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi2.A.89.1.2. the vacuolar iron transporter (vit) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar iron transporter 1
Short name:
AtVIT1
Gene namesi
Name:VIT1
Ordered Locus Names:At2g01770
ORF Names:T8O11.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G01770.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 64VacuolarSequence analysis6
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 169CytoplasmicSequence analysisAdd BLAST84
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 192VacuolarSequence analysis2
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 227CytoplasmicSequence analysisAdd BLAST14
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 250VacuolarSequence analysis2

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition, but important reduced growth and leaves with severe chlorosis when grown on soil at pH 7.9 that causes limited iron availability.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004110041 – 250Vacuolar iron transporter 1Add BLAST250

Proteomic databases

PaxDbiQ9ZUA5.

Expressioni

Tissue specificityi

Highly expressed in developing embryo and seed. Expressed in young seedlings, predominantly in the vasculature.1 Publication

Gene expression databases

GenevisibleiQ9ZUA5. AT.

Interactioni

Protein-protein interaction databases

BioGridi111. 16 interactors.
IntActiQ9ZUA5. 4 interactors.
STRINGi3702.AT2G01770.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZUA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4473. Eukaryota.
COG1814. LUCA.
HOGENOMiHOG000096548.
InParanoidiQ9ZUA5.
OMAiKWVDFMM.
OrthoDBiEOG09360MP2.
PhylomeDBiQ9ZUA5.

Family and domain databases

InterProiIPR008217. Ccc1_fam.
[Graphical view]
PfamiPF01988. VIT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZUA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEEDKITR ISIEPEKQTL LDHHTEKHFT AGEIVRDIII GVSDGLTVPF
60 70 80 90 100
ALAAGLSGAN ASSSIVLTAG IAEVAAGAIS MGLGGYLAAK SEEDHYAREM
110 120 130 140 150
KREQEEIVAV PETEAAEVAE ILAQYGIEPH EYSPVVNALR KNPQAWLDFM
160 170 180 190 200
MRFELGLEKP DPKRALQSAF TIAIAYVLGG FIPLLPYMLI PHAMDAVVAS
210 220 230 240 250
VVITLFALFI FGYAKGHFTG SKPLRSAFET AFIGAIASAA AFCLAKVVQH
Length:250
Mass (Da):26,860
Last modified:May 1, 1999 - v1
Checksum:i4B481BE5476DF348
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY316134 mRNA. Translation: AAQ87602.1.
AC006069 Genomic DNA. Translation: AAD12695.1.
CP002685 Genomic DNA. Translation: AEC05496.1.
BT028987 mRNA. Translation: ABI93896.1.
PIRiH84428.
RefSeqiNP_178286.1. NM_126238.3.
UniGeneiAt.52589.

Genome annotation databases

EnsemblPlantsiAT2G01770.1; AT2G01770.1; AT2G01770.
GeneIDi814708.
GrameneiAT2G01770.1; AT2G01770.1; AT2G01770.
KEGGiath:AT2G01770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY316134 mRNA. Translation: AAQ87602.1.
AC006069 Genomic DNA. Translation: AAD12695.1.
CP002685 Genomic DNA. Translation: AEC05496.1.
BT028987 mRNA. Translation: ABI93896.1.
PIRiH84428.
RefSeqiNP_178286.1. NM_126238.3.
UniGeneiAt.52589.

3D structure databases

ProteinModelPortaliQ9ZUA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111. 16 interactors.
IntActiQ9ZUA5. 4 interactors.
STRINGi3702.AT2G01770.1.

Protein family/group databases

TCDBi2.A.89.1.2. the vacuolar iron transporter (vit) family.

Proteomic databases

PaxDbiQ9ZUA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G01770.1; AT2G01770.1; AT2G01770.
GeneIDi814708.
GrameneiAT2G01770.1; AT2G01770.1; AT2G01770.
KEGGiath:AT2G01770.

Organism-specific databases

TAIRiAT2G01770.

Phylogenomic databases

eggNOGiKOG4473. Eukaryota.
COG1814. LUCA.
HOGENOMiHOG000096548.
InParanoidiQ9ZUA5.
OMAiKWVDFMM.
OrthoDBiEOG09360MP2.
PhylomeDBiQ9ZUA5.

Miscellaneous databases

PROiQ9ZUA5.

Gene expression databases

GenevisibleiQ9ZUA5. AT.

Family and domain databases

InterProiIPR008217. Ccc1_fam.
[Graphical view]
PfamiPF01988. VIT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIT1_ARATH
AccessioniPrimary (citable) accession number: Q9ZUA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Can mediate iron sequestration into vacuoles when expressed in the yeast ccc1 mutant. In seeds, iron is strongly localized to the provascular strands of the hypocotyl, radicle, and cotyledons, but completely absent from these cells in vit1-1 mutant.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.