Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sulfhydryl oxidase 2

Gene

QSOX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADPROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66NucleophileBy similarity1
Active sitei69NucleophileBy similarity1
Binding sitei295FADBy similarity1
Binding sitei302FADBy similarity1
Binding sitei306FADBy similarity1
Binding sitei336FADBy similarity1
Binding sitei340FADBy similarity1
Binding sitei389FADBy similarity1
Binding sitei392FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi363 – 370FADBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT2G01270-MONOMER.
ReactomeiR-ATH-114608. Platelet degranulation.
R-ATH-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin-sulfhydryl oxidase 2
Short name:
AtQSOX2
Gene namesi
Name:QSOX2
Ordered Locus Names:At2g01270
ORF Names:F10A8.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G01270.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: TAIR
  • extracellular space Source: GO_Central
  • Golgi apparatus Source: TAIR
  • integral component of Golgi membrane Source: GO_Central
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000040005116 – 495Sulfhydryl oxidase 2Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi66 ↔ 69Redox-activePROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi287 ↔ 299PROSITE-ProRule annotation
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi334 ↔ 337PROSITE-ProRule annotation
Disulfide bondi398 ↔ 401PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ZU40.

PTM databases

SwissPalmiQ9ZU40.

Expressioni

Gene expression databases

GenevisibleiQ9ZU40. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G01270.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZU40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 164ThioredoxinPROSITE-ProRule annotationAdd BLAST136
Domaini290 – 392ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiKOG1731. Eukaryota.
ENOG410XVJT. LUCA.
HOGENOMiHOG000029909.
InParanoidiQ9ZU40.
KOiK10758.
OMAiFASAKWD.
OrthoDBiEOG093607HV.
PhylomeDBiQ9ZU40.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZU40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVHLLLFA GLVIAASSSS PGSRLILREI SDQKDKAVEL NTTNFDSVLK
60 70 80 90 100
DTPAKYAVVE FFAHWCPACR NYKPHYEKVA RLFNGPDAIH PGIVLMTRVD
110 120 130 140 150
CAMKTNTKLC DKFSVSHYPM LFWGPPTKFV SGSWEPKKDK SEILVIDDGR
160 170 180 190 200
TAERLLNWIN KQIGSSYGLD DQKFKNEHAL SNLTDYNQIS QAVYDVEEAT
210 220 230 240 250
AEAFDIILAH KAIKSSETSA SFIRFIQLLA AHHLSRRCRK GAAEILVNYD
260 270 280 290 300
DLCPSGNCSY EKSGGNDTLG NFPICGKDVP RGYYMFCRGS KNDTRGFSCG
310 320 330 340 350
LWVLMHSLSV RIEDGESHFA FTTICDFVNN FFMCDECRLH FNDMCLSVKT
360 370 380 390 400
PFKKARDFVL WVWSTHNKVN ERLLKDEASL GTGDPKFPKI IWPPKELCPL
410 420 430 440 450
CYLSSNQKSI EWDHEHVYKF LKNYYGPKLV SLYKEKSVSR SKEETVSATE
460 470 480 490
DLTVATNALV VPIGAALAIA IASCAFGALA CYWRTQQKNR KPRRR
Length:495
Mass (Da):55,919
Last modified:June 1, 2002 - v2
Checksum:i2FBBFA72D9C0A95D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85G → D in AAK59679 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006200 Genomic DNA. Translation: AAD14527.2.
CP002685 Genomic DNA. Translation: AEC05425.1.
AY035175 mRNA. Translation: AAK59679.1.
AY090364 mRNA. Translation: AAL91267.1.
AY125539 mRNA. Translation: AAM78049.1.
BT000880 mRNA. Translation: AAN41280.1.
PIRiF84422.
RefSeqiNP_565258.1. NM_126188.4.
UniGeneiAt.20100.

Genome annotation databases

EnsemblPlantsiAT2G01270.1; AT2G01270.1; AT2G01270.
GeneIDi814654.
GrameneiAT2G01270.1; AT2G01270.1; AT2G01270.
KEGGiath:AT2G01270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006200 Genomic DNA. Translation: AAD14527.2.
CP002685 Genomic DNA. Translation: AEC05425.1.
AY035175 mRNA. Translation: AAK59679.1.
AY090364 mRNA. Translation: AAL91267.1.
AY125539 mRNA. Translation: AAM78049.1.
BT000880 mRNA. Translation: AAN41280.1.
PIRiF84422.
RefSeqiNP_565258.1. NM_126188.4.
UniGeneiAt.20100.

3D structure databases

ProteinModelPortaliQ9ZU40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G01270.1.

PTM databases

SwissPalmiQ9ZU40.

Proteomic databases

PaxDbiQ9ZU40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G01270.1; AT2G01270.1; AT2G01270.
GeneIDi814654.
GrameneiAT2G01270.1; AT2G01270.1; AT2G01270.
KEGGiath:AT2G01270.

Organism-specific databases

TAIRiAT2G01270.

Phylogenomic databases

eggNOGiKOG1731. Eukaryota.
ENOG410XVJT. LUCA.
HOGENOMiHOG000029909.
InParanoidiQ9ZU40.
KOiK10758.
OMAiFASAKWD.
OrthoDBiEOG093607HV.
PhylomeDBiQ9ZU40.

Enzyme and pathway databases

BioCyciARA:AT2G01270-MONOMER.
ReactomeiR-ATH-114608. Platelet degranulation.
R-ATH-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9ZU40.

Gene expression databases

GenevisibleiQ9ZU40. AT.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQSOX2_ARATH
AccessioniPrimary (citable) accession number: Q9ZU40
Secondary accession number(s): Q94C52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.