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Protein

Sulfhydryl oxidase 2

Gene

QSOX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADPROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661NucleophileBy similarity
Active sitei69 – 691NucleophileBy similarity
Binding sitei295 – 2951FADBy similarity
Binding sitei302 – 3021FADBy similarity
Binding sitei306 – 3061FADBy similarity
Binding sitei336 – 3361FADBy similarity
Binding sitei340 – 3401FADBy similarity
Binding sitei389 – 3891FADBy similarity
Binding sitei392 – 3921FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi363 – 3708FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT2G01270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin-sulfhydryl oxidase 2
Short name:
AtQSOX2
Gene namesi
Name:QSOX2
Ordered Locus Names:At2g01270
ORF Names:F10A8.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G01270.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: TAIR
  • extracellular space Source: GO_Central
  • Golgi apparatus Source: TAIR
  • integral component of Golgi membrane Source: GO_Central
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 495480Sulfhydryl oxidase 2PRO_0000400051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi66 ↔ 69Redox-activePROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi287 ↔ 299PROSITE-ProRule annotation
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi334 ↔ 337PROSITE-ProRule annotation
Disulfide bondi398 ↔ 401PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ZU40.
PRIDEiQ9ZU40.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G01270.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZU40.
SMRiQ9ZU40. Positions 38-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 164136ThioredoxinPROSITE-ProRule annotationAdd
BLAST
Domaini290 – 392103ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiNOG237986.
HOGENOMiHOG000029909.
InParanoidiQ9ZU40.
KOiK10758.
OMAiPKVTWPP.
PhylomeDBiQ9ZU40.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZU40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVHLLLFA GLVIAASSSS PGSRLILREI SDQKDKAVEL NTTNFDSVLK
60 70 80 90 100
DTPAKYAVVE FFAHWCPACR NYKPHYEKVA RLFNGPDAIH PGIVLMTRVD
110 120 130 140 150
CAMKTNTKLC DKFSVSHYPM LFWGPPTKFV SGSWEPKKDK SEILVIDDGR
160 170 180 190 200
TAERLLNWIN KQIGSSYGLD DQKFKNEHAL SNLTDYNQIS QAVYDVEEAT
210 220 230 240 250
AEAFDIILAH KAIKSSETSA SFIRFIQLLA AHHLSRRCRK GAAEILVNYD
260 270 280 290 300
DLCPSGNCSY EKSGGNDTLG NFPICGKDVP RGYYMFCRGS KNDTRGFSCG
310 320 330 340 350
LWVLMHSLSV RIEDGESHFA FTTICDFVNN FFMCDECRLH FNDMCLSVKT
360 370 380 390 400
PFKKARDFVL WVWSTHNKVN ERLLKDEASL GTGDPKFPKI IWPPKELCPL
410 420 430 440 450
CYLSSNQKSI EWDHEHVYKF LKNYYGPKLV SLYKEKSVSR SKEETVSATE
460 470 480 490
DLTVATNALV VPIGAALAIA IASCAFGALA CYWRTQQKNR KPRRR
Length:495
Mass (Da):55,919
Last modified:June 1, 2002 - v2
Checksum:i2FBBFA72D9C0A95D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851G → D in AAK59679 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006200 Genomic DNA. Translation: AAD14527.2.
CP002685 Genomic DNA. Translation: AEC05425.1.
AY035175 mRNA. Translation: AAK59679.1.
AY090364 mRNA. Translation: AAL91267.1.
AY125539 mRNA. Translation: AAM78049.1.
BT000880 mRNA. Translation: AAN41280.1.
PIRiF84422.
RefSeqiNP_565258.1. NM_126188.3.
UniGeneiAt.20100.

Genome annotation databases

EnsemblPlantsiAT2G01270.1; AT2G01270.1; AT2G01270.
GeneIDi814654.
KEGGiath:AT2G01270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006200 Genomic DNA. Translation: AAD14527.2.
CP002685 Genomic DNA. Translation: AEC05425.1.
AY035175 mRNA. Translation: AAK59679.1.
AY090364 mRNA. Translation: AAL91267.1.
AY125539 mRNA. Translation: AAM78049.1.
BT000880 mRNA. Translation: AAN41280.1.
PIRiF84422.
RefSeqiNP_565258.1. NM_126188.3.
UniGeneiAt.20100.

3D structure databases

ProteinModelPortaliQ9ZU40.
SMRiQ9ZU40. Positions 38-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G01270.1.

Proteomic databases

PaxDbiQ9ZU40.
PRIDEiQ9ZU40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G01270.1; AT2G01270.1; AT2G01270.
GeneIDi814654.
KEGGiath:AT2G01270.

Organism-specific databases

TAIRiAT2G01270.

Phylogenomic databases

eggNOGiNOG237986.
HOGENOMiHOG000029909.
InParanoidiQ9ZU40.
KOiK10758.
OMAiPKVTWPP.
PhylomeDBiQ9ZU40.

Enzyme and pathway databases

BioCyciARA:AT2G01270-MONOMER.

Miscellaneous databases

PROiQ9ZU40.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiQSOX2_ARATH
AccessioniPrimary (citable) accession number: Q9ZU40
Secondary accession number(s): Q94C52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 1, 2002
Last modified: June 24, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.