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Protein

Sulfhydryl oxidase 2

Gene

QSOX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADPROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66NucleophileBy similarity1
Active sitei69NucleophileBy similarity1
Binding sitei295FADBy similarity1
Binding sitei302FADBy similarity1
Binding sitei306FADBy similarity1
Binding sitei336FADBy similarity1
Binding sitei340FADBy similarity1
Binding sitei389FADBy similarity1
Binding sitei392FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi363 – 370FADBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT2G01270-MONOMER
ReactomeiR-ATH-114608 Platelet degranulation
R-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin-sulfhydryl oxidase 2
Short name:
AtQSOX2
Gene namesi
Name:QSOX2
Ordered Locus Names:At2g01270
ORF Names:F10A8.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G01270
TAIRilocus:2038771 AT2G01270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000040005116 – 495Sulfhydryl oxidase 2Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi66 ↔ 69Redox-activePROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi287 ↔ 299PROSITE-ProRule annotation
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi334 ↔ 337PROSITE-ProRule annotation
Disulfide bondi398 ↔ 401PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ZU40

PTM databases

SwissPalmiQ9ZU40

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZU40 baseline and differential
GenevisibleiQ9ZU40 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G01270.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZU40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 164ThioredoxinPROSITE-ProRule annotationAdd BLAST136
Domaini290 – 392ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST103

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiKOG1731 Eukaryota
ENOG410XVJT LUCA
HOGENOMiHOG000029909
InParanoidiQ9ZU40
KOiK10758
OMAiKLGQHAT
OrthoDBiEOG093607HV
PhylomeDBiQ9ZU40

Family and domain databases

Gene3Di1.20.120.310, 1 hit
InterProiView protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF04777 Evr1_Alr, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF69000 SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324 ERV_ALR, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZU40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVHLLLFA GLVIAASSSS PGSRLILREI SDQKDKAVEL NTTNFDSVLK
60 70 80 90 100
DTPAKYAVVE FFAHWCPACR NYKPHYEKVA RLFNGPDAIH PGIVLMTRVD
110 120 130 140 150
CAMKTNTKLC DKFSVSHYPM LFWGPPTKFV SGSWEPKKDK SEILVIDDGR
160 170 180 190 200
TAERLLNWIN KQIGSSYGLD DQKFKNEHAL SNLTDYNQIS QAVYDVEEAT
210 220 230 240 250
AEAFDIILAH KAIKSSETSA SFIRFIQLLA AHHLSRRCRK GAAEILVNYD
260 270 280 290 300
DLCPSGNCSY EKSGGNDTLG NFPICGKDVP RGYYMFCRGS KNDTRGFSCG
310 320 330 340 350
LWVLMHSLSV RIEDGESHFA FTTICDFVNN FFMCDECRLH FNDMCLSVKT
360 370 380 390 400
PFKKARDFVL WVWSTHNKVN ERLLKDEASL GTGDPKFPKI IWPPKELCPL
410 420 430 440 450
CYLSSNQKSI EWDHEHVYKF LKNYYGPKLV SLYKEKSVSR SKEETVSATE
460 470 480 490
DLTVATNALV VPIGAALAIA IASCAFGALA CYWRTQQKNR KPRRR
Length:495
Mass (Da):55,919
Last modified:June 1, 2002 - v2
Checksum:i2FBBFA72D9C0A95D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85G → D in AAK59679 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006200 Genomic DNA Translation: AAD14527.2
CP002685 Genomic DNA Translation: AEC05425.1
AY035175 mRNA Translation: AAK59679.1
AY090364 mRNA Translation: AAL91267.1
AY125539 mRNA Translation: AAM78049.1
BT000880 mRNA Translation: AAN41280.1
PIRiF84422
RefSeqiNP_565258.1, NM_126188.4
UniGeneiAt.20100

Genome annotation databases

EnsemblPlantsiAT2G01270.1; AT2G01270.1; AT2G01270
GeneIDi814654
GrameneiAT2G01270.1; AT2G01270.1; AT2G01270
KEGGiath:AT2G01270

Similar proteinsi

Entry informationi

Entry nameiQSOX2_ARATH
AccessioniPrimary (citable) accession number: Q9ZU40
Secondary accession number(s): Q94C52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

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