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Q9ZU40

- QSOX2_ARATH

UniProt

Q9ZU40 - QSOX2_ARATH

Protein

Sulfhydryl oxidase 2

Gene

QSOX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.By similarity

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    FAD.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661NucleophileBy similarity
    Active sitei69 – 691NucleophileBy similarity
    Binding sitei295 – 2951FADBy similarity
    Binding sitei302 – 3021FADBy similarity
    Binding sitei306 – 3061FADBy similarity
    Binding sitei336 – 3361FADBy similarity
    Binding sitei340 – 3401FADBy similarity
    Binding sitei389 – 3891FADBy similarity
    Binding sitei392 – 3921FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi363 – 3708FADBy similarity

    GO - Molecular functioni

    1. thiol oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciARA:AT2G01270-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfhydryl oxidase 2 (EC:1.8.3.2)
    Alternative name(s):
    Quiescin-sulfhydryl oxidase 2
    Short name:
    AtQSOX2
    Gene namesi
    Name:QSOX2
    Ordered Locus Names:At2g01270
    ORF Names:F10A8.15
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G01270.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. endosome Source: TAIR
    2. extracellular region Source: UniProtKB-SubCell
    3. Golgi apparatus Source: TAIR
    4. trans-Golgi network Source: TAIR

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 495480Sulfhydryl oxidase 2PRO_0000400051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi66 ↔ 69Redox-activePROSITE-ProRule annotation
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi287 ↔ 299PROSITE-ProRule annotation
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi334 ↔ 337PROSITE-ProRule annotation
    Disulfide bondi398 ↔ 401PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9ZU40.
    PRIDEiQ9ZU40.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ZU40.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G01270.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZU40.
    SMRiQ9ZU40. Positions 38-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 164136ThioredoxinPROSITE-ProRule annotationAdd
    BLAST
    Domaini290 – 392103ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Signal

    Phylogenomic databases

    eggNOGiNOG237986.
    HOGENOMiHOG000029909.
    InParanoidiQ9ZU40.
    OMAiSGSWEPK.
    PhylomeDBiQ9ZU40.

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ZU40-1 [UniParc]FASTAAdd to Basket

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    MSLVHLLLFA GLVIAASSSS PGSRLILREI SDQKDKAVEL NTTNFDSVLK    50
    DTPAKYAVVE FFAHWCPACR NYKPHYEKVA RLFNGPDAIH PGIVLMTRVD 100
    CAMKTNTKLC DKFSVSHYPM LFWGPPTKFV SGSWEPKKDK SEILVIDDGR 150
    TAERLLNWIN KQIGSSYGLD DQKFKNEHAL SNLTDYNQIS QAVYDVEEAT 200
    AEAFDIILAH KAIKSSETSA SFIRFIQLLA AHHLSRRCRK GAAEILVNYD 250
    DLCPSGNCSY EKSGGNDTLG NFPICGKDVP RGYYMFCRGS KNDTRGFSCG 300
    LWVLMHSLSV RIEDGESHFA FTTICDFVNN FFMCDECRLH FNDMCLSVKT 350
    PFKKARDFVL WVWSTHNKVN ERLLKDEASL GTGDPKFPKI IWPPKELCPL 400
    CYLSSNQKSI EWDHEHVYKF LKNYYGPKLV SLYKEKSVSR SKEETVSATE 450
    DLTVATNALV VPIGAALAIA IASCAFGALA CYWRTQQKNR KPRRR 495
    Length:495
    Mass (Da):55,919
    Last modified:June 1, 2002 - v2
    Checksum:i2FBBFA72D9C0A95D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851G → D in AAK59679. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006200 Genomic DNA. Translation: AAD14527.2.
    CP002685 Genomic DNA. Translation: AEC05425.1.
    AY035175 mRNA. Translation: AAK59679.1.
    AY090364 mRNA. Translation: AAL91267.1.
    AY125539 mRNA. Translation: AAM78049.1.
    BT000880 mRNA. Translation: AAN41280.1.
    PIRiF84422.
    RefSeqiNP_565258.1. NM_126188.3.
    UniGeneiAt.20100.

    Genome annotation databases

    EnsemblPlantsiAT2G01270.1; AT2G01270.1; AT2G01270.
    GeneIDi814654.
    KEGGiath:AT2G01270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006200 Genomic DNA. Translation: AAD14527.2 .
    CP002685 Genomic DNA. Translation: AEC05425.1 .
    AY035175 mRNA. Translation: AAK59679.1 .
    AY090364 mRNA. Translation: AAL91267.1 .
    AY125539 mRNA. Translation: AAM78049.1 .
    BT000880 mRNA. Translation: AAN41280.1 .
    PIRi F84422.
    RefSeqi NP_565258.1. NM_126188.3.
    UniGenei At.20100.

    3D structure databases

    ProteinModelPortali Q9ZU40.
    SMRi Q9ZU40. Positions 38-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G01270.1-P.

    Proteomic databases

    PaxDbi Q9ZU40.
    PRIDEi Q9ZU40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G01270.1 ; AT2G01270.1 ; AT2G01270 .
    GeneIDi 814654.
    KEGGi ath:AT2G01270.

    Organism-specific databases

    TAIRi AT2G01270.

    Phylogenomic databases

    eggNOGi NOG237986.
    HOGENOMi HOG000029909.
    InParanoidi Q9ZU40.
    OMAi SGSWEPK.
    PhylomeDBi Q9ZU40.

    Enzyme and pathway databases

    BioCyci ARA:AT2G01270-MONOMER.

    Gene expression databases

    Genevestigatori Q9ZU40.

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiQSOX2_ARATH
    AccessioniPrimary (citable) accession number: Q9ZU40
    Secondary accession number(s): Q94C52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3