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Q9ZU06

- CHSY_PERAE

UniProt

Q9ZU06 - CHSY_PERAE

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Protein

Chalcone synthase

Gene

CHS

Organism
Persea americana (Avocado)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naregenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiPersea americana (Avocado)
Taxonomic identifieri3435 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaMagnoliidaeLauralesLauraceaePersea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Chalcone synthasePRO_0000216026Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9ZU06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 3 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZU06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNVEAIRKV QRAEGPATIM AIGTSTPPNA VDQSEYPDYY YFGSPTASTR
60 70 80 90 100
PSSRRSFKRM CEKSMIKKRY MYLTETYWKR IQMFVPTWLL PLKARQDMVV
110 120 130 140 150
VEVPKLGKEV QPKAIKGMGQ PKSKINPLVF CTTSGVDMPG ADYQLTKVFG
160 170 180 190 200
LPPSVKRLMM YQQGCFAGGT VLRLAKDLAE NNKGARVLVV CSEITAVTFR
210 220 230 240 250
GPSDTHLDSL VGQALFGDGA AALIVGADPV PGVENPMFEL VSAGQTILPD
260 270 280 290 300
SDGAIDGHLR EVGLTFHLLK VVPGLISKNI EKSLVEAFEP LGISDWNSLF
310 320 330 340 350
WIAHPGGPAI LDPGGDQTRP EARESCGNQA CFSVSMATCQ VFVCSSFSTR
360 370 380 390
CEGSPKEEGL KTTGEGIEWG VLFGFGPGLT VETVVLHSLP TH
Length:392
Mass (Da):42,480
Last modified:May 1, 1999 - v1
Checksum:iB08D286FB80BB42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001672 mRNA. Translation: AAC98143.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001672 mRNA. Translation: AAC98143.1 .

3D structure databases

ProteinModelPortali Q9ZU06.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 3 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Involvement of epicatechin biosynthesis in the activation of the mechanism of resistance of avocado fruits to Colletotrichum gloeosporioides."
    Ardi R., Kobiler I., Jacoby B., Keen N.T., Prusky D.
    Physiol. Mol. Plant Pathol. 53:269-286(1998)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCHSY_PERAE
AccessioniPrimary (citable) accession number: Q9ZU06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3