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Q9ZU06 (CHSY_PERAE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naregenin-chalcone synthase
Gene names
Name:CHS
OrganismPersea americana (Avocado)
Taxonomic identifier3435 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaMagnoliidaeLauralesLauraceaePersea

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Chalcone synthase
PRO_0000216026

Sites

Active site1651 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZU06 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B08D286FB80BB42E

FASTA39242,480
        10         20         30         40         50         60 
MVNVEAIRKV QRAEGPATIM AIGTSTPPNA VDQSEYPDYY YFGSPTASTR PSSRRSFKRM 

        70         80         90        100        110        120 
CEKSMIKKRY MYLTETYWKR IQMFVPTWLL PLKARQDMVV VEVPKLGKEV QPKAIKGMGQ 

       130        140        150        160        170        180 
PKSKINPLVF CTTSGVDMPG ADYQLTKVFG LPPSVKRLMM YQQGCFAGGT VLRLAKDLAE 

       190        200        210        220        230        240 
NNKGARVLVV CSEITAVTFR GPSDTHLDSL VGQALFGDGA AALIVGADPV PGVENPMFEL 

       250        260        270        280        290        300 
VSAGQTILPD SDGAIDGHLR EVGLTFHLLK VVPGLISKNI EKSLVEAFEP LGISDWNSLF 

       310        320        330        340        350        360 
WIAHPGGPAI LDPGGDQTRP EARESCGNQA CFSVSMATCQ VFVCSSFSTR CEGSPKEEGL 

       370        380        390 
KTTGEGIEWG VLFGFGPGLT VETVVLHSLP TH 

« Hide

References

[1]"Involvement of epicatechin biosynthesis in the activation of the mechanism of resistance of avocado fruits to Colletotrichum gloeosporioides."
Ardi R., Kobiler I., Jacoby B., Keen N.T., Prusky D.
Physiol. Mol. Plant Pathol. 53:269-286(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AD001672 mRNA. Translation: AAC98143.1.

3D structure databases

ProteinModelPortalQ9ZU06.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 3 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_PERAE
AccessionPrimary (citable) accession number: Q9ZU06
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1999
Last modified: November 13, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways