Q9ZU06 (CHSY_PERAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chalcone synthase
EC=2.3.1.74

Alternative name(s):
Naregenin-chalcone synthase

Gene names

Name:

CHS

Organism

Persea americana (Avocado)

Taxonomic identifier

3435 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › magnoliids › Laurales › Lauraceae › Persea

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
Catalytic activity	3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.
Pathway	Secondary metabolite biosynthesis; flavonoid biosynthesis.
Sequence similarities	Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
Biological process	Flavonoid biosynthesis
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological_process	flavonoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	naringenin-chalcone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Chalcone synthase		PRO_0000216026
Sites
	Active site	165	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZU06 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B08D286FB80BB42E	FASTA	392	42,480
	10 20 30 40 50 60 MVNVEAIRKV QRAEGPATIM AIGTSTPPNA VDQSEYPDYY YFGSPTASTR PSSRRSFKRM 70 80 90 100 110 120 CEKSMIKKRY MYLTETYWKR IQMFVPTWLL PLKARQDMVV VEVPKLGKEV QPKAIKGMGQ 130 140 150 160 170 180 PKSKINPLVF CTTSGVDMPG ADYQLTKVFG LPPSVKRLMM YQQGCFAGGT VLRLAKDLAE 190 200 210 220 230 240 NNKGARVLVV CSEITAVTFR GPSDTHLDSL VGQALFGDGA AALIVGADPV PGVENPMFEL 250 260 270 280 290 300 VSAGQTILPD SDGAIDGHLR EVGLTFHLLK VVPGLISKNI EKSLVEAFEP LGISDWNSLF 310 320 330 340 350 360 WIAHPGGPAI LDPGGDQTRP EARESCGNQA CFSVSMATCQ VFVCSSFSTR CEGSPKEEGL 370 380 390 KTTGEGIEWG VLFGFGPGLT VETVVLHSLP TH

References

[1]	"Involvement of epicatechin biosynthesis in the activation of the mechanism of resistance of avocado fruits to Colletotrichum gloeosporioides." Ardi R., Kobiler I., Jacoby B., Keen N.T., Prusky D. Physiol. Mol. Plant Pathol. 53:269-286(1998) Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AD001672 mRNA. Translation: AAC98143.1.
3D structure databases
ProteinModelPortal	Q9ZU06.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00154.
Family and domain databases
Gene3D	3.40.47.10. 3 hits.
InterPro	IPR012328. Chalcone/stilbene_synth_C. IPR018088. Chalcone/stilbene_synthase_AS. IPR001099. Chalcone/stilbene_synthase_N. IPR011141. Polyketide_synthase_type-III. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF02797. Chal_sti_synt_C. 1 hit. PF00195. Chal_sti_synt_N. 1 hit. [Graphical view]
PIRSF	PIRSF000451. PKS_III. 1 hit.
SUPFAM	SSF53901. Thiolase-like. 2 hits.
PROSITE	PS00441. CHALCONE_SYNTH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHSY_PERAE

Accession

Primary (citable) accession number: Q9ZU06

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	May 1, 1999
Last modified:	March 6, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program