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Q9ZTU2

- Q9ZTU2_LOLPR

UniProt

Q9ZTU2 - Q9ZTU2_LOLPR

Protein
Submitted name:

Caffeic acid O-methyltransferase

Gene

OMT1

Organism
Lolium perenne (Perennial ryegrass)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei160 – 1601S-adenosyl-L-homocysteine 1Imported
    Binding sitei181 – 1811S-adenosyl-L-homocysteine 1Imported
    Binding sitei205 – 2051S-adenosyl-L-homocysteine 1; via carbonyl oxygenImported
    Binding sitei228 – 2281S-adenosyl-L-homocysteine 1Imported
    Binding sitei228 – 2281S-adenosyl-L-homocysteine 2
    Binding sitei262 – 2621S-adenosyl-L-homocysteine 1Imported
    Binding sitei262 – 2621S-adenosyl-L-homocysteine 2
    Active sitei266 – 2661Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. catechol O-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    MethyltransferaseSAAS annotationImported, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Caffeic acid O-methyltransferaseImported (EC:2.1.1.6Imported)
    Gene namesi
    Name:OMT1Imported
    OrganismiLolium perenne (Perennial ryegrass)Imported
    Taxonomic identifieri4522 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaePoeaeLoliinaeLolium

    Organism-specific databases

    GrameneiQ9ZTU2.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3P9CX-ray1.80A1-360[»]
    3P9IX-ray1.85A/B/C/D1-360[»]
    3P9KX-ray2.25A/B/C/D1-360[»]
    ProteinModelPortaliQ9ZTU2.
    SMRiQ9ZTU2. Positions 2-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ZTU2.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni205 – 2062S-adenosyl-L-homocysteine 2 binding
    Regioni248 – 2492S-adenosyl-L-homocysteine 1 bindingImported
    Regioni248 – 2492S-adenosyl-L-homocysteine 2 binding

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.40.50.150. 1 hit.
    InterProiIPR016461. COMT.
    IPR001077. O_MeTrfase_2.
    IPR012967. Plant_MeTrfase_dimerisation.
    IPR029063. SAM-dependent_MTases-like.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF08100. Dimerisation. 1 hit.
    PF00891. Methyltransf_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005739. O-mtase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51588. SAM_MT_COMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZTU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSTAADMAA SADEDACMFA LQLASSSVLP MTLKNAIELG LLEILVAAGG    50
    KSLTPTEVAA KLPSAANPEA PDMVDRILRL LASYNVVTCL VEEGKDGRLS 100
    RSYGAAPVCK FLTPNEDGVS MAALALMNQD KVLMESWYYL KDAVLDGGIP 150
    FNKAYGMSAF EYHGTDPRFN RVFNEGMKNH SIIITKKLLE LYHGFEGLGT 200
    LVDVGGGVGA TVAAIAAHYP TIKGVNFDLP HVISEAPQFP GVTHVGGDMF 250
    KEVPSGDTIL MKWILHDWSD QHCATLLKNC YDALPAHGKV VLVQCILPVN 300
    PEANPSSQGV FHVDMIMLAH NPGGRERYER EFQALARGAG FTGVKSTYIY 350
    ANAWAIEFTK 360
    Length:360
    Mass (Da):38,769
    Last modified:May 1, 1999 - v1
    Checksum:iB018C8300962FA14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033538 mRNA. Translation: AAD10253.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033538 mRNA. Translation: AAD10253.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3P9C X-ray 1.80 A 1-360 [» ]
    3P9I X-ray 1.85 A/B/C/D 1-360 [» ]
    3P9K X-ray 2.25 A/B/C/D 1-360 [» ]
    ProteinModelPortali Q9ZTU2.
    SMRi Q9ZTU2. Positions 2-360.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q9ZTU2.

    Miscellaneous databases

    EvolutionaryTracei Q9ZTU2.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.40.50.150. 1 hit.
    InterProi IPR016461. COMT.
    IPR001077. O_MeTrfase_2.
    IPR012967. Plant_MeTrfase_dimerisation.
    IPR029063. SAM-dependent_MTases-like.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF08100. Dimerisation. 1 hit.
    PF00891. Methyltransf_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005739. O-mtase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51588. SAM_MT_COMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and differential expression of three caffeic acid O-methyltransferase homologues from Lolium perenne."
      Heath R.L., Huxley H., Stone B.A., Spangenberg G.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference."
      Louie G.V., Bowman M.E., Tu Y., Mouradov A., Spangenberg G., Noel J.P.
      Plant Cell 22:4114-4127(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

    Entry informationi

    Entry nameiQ9ZTU2_LOLPR
    AccessioniPrimary (citable) accession number: Q9ZTU2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3