Reviewed, UniProtKB/Swiss-Prot Q9ZSZ8 (FIP37_ARATH)

Names and origin

Protein names

Recommended name:
    FKBP12-interacting protein of 37 kDa
      Short name=FIP-37
Alternative name(s):
    Immunophilin-interacting protein AtFIP37

Gene names

Name:	FIP37
Ordered Locus Names:	At3g54170
ORF Names:	F24B22.130

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especially in trichomes. May play a role in splicing events. Ref.4
Subunit structure	Its interaction with FKBP12 is inhibited by the immunosuppressive drug FK506.
Subcellular location	Nucleus speckle. Note: Nuclear with a speckled distribution pattern. Ref.4
Tissue specificity	Ubiquitously expressed with higer levels in primary and lateral roots, leaves, trichomes, and in pollen grains (at protein level). Ref.4
Disruption phenotype	Embryogenesis arrest at the midglobular stage. Ref.4
Sequence similarities	Belongs to the fl(2)d family.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EMB1706	O82486	3	EBI-1641243,EBI-1797380
FKBP12	Q8LGG0	3	EBI-1641243,EBI-1641228

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	FKBP12-interacting protein of 37 kDa		PRO_0000087258
Regions
	Coiled coil	56 – 308	253	Potential
	Compositional bias	224 – 330	107	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9ZSZ8-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6B4070D5AD332004	FASTA	330	37,215
	10 20 30 40 50 60 MEFSSQDDDF GGDDSAANAT RASGNRRSFG DLEDDEDDIF GSTTVAPGVR TGMILSLRGS 70 80 90 100 110 120 LKNCKDDLAS CQNELESAKT EIQKWKSAFQ NESFVPAGKS PEPRFLIDYI QNLKSSEKSL 130 140 150 160 170 180 KEQLEIAKRK EASCIVQYAK REQEMAELKS AVRDLKSQLK PASMQARRLL LDPAIHEEFS 190 200 210 220 230 240 RLKNLVEEKD KKIKELQDNI AAVTFTPQSK NGKMLMAKCR TLQEENEEIG HQAAEGKIHE 250 260 270 280 290 300 LAIKLAMQKS QNAELRSQFE GLYKHMEELT NDVERSNETV IILQEKLEEK EKEIERVKKG 310 320 330 LEIVSELVGD KKDEVDEIDE DAKEEIAGGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506." Faure J.-D., Gingerich D., Howell S.H. Plant J. 15:783-789(1998) [PubMed: 9807817] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH FKBP12. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication." Vespa L., Vachon G., Berger F., Perazza D., Faure J.-D., Herzog M. Plant Physiol. 134:1283-1292(2004) [PubMed: 15047892] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF084570 mRNA. Translation: AAC72922.1. AL132957 Genomic DNA. Translation: CAB70991.1. AY063940 mRNA. Translation: AAL36296.1. AY113943 mRNA. Translation: AAM44991.1.
IPI	IPI00547351.
PIR	T47576.
RefSeq	NP_190985.1.
UniGene	At.930
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ZSZ8. 2 interactions.
STRING	Q9ZSZ8.
Proteomic databases
PRIDE	Q9ZSZ8.
Genome annotation databases
GeneID	824584.
GenomeReviews	Gene locus AT3G54170 in contig BA000014_GR.
KEGG	ath:AT3G54170.
NMPDR	fig|3702.1.peg.16716.
Organism-specific databases
GeneFarm	5057.
TAIR	At3g54170.
Phylogenomic databases
OMA	FIVTFAK
Gene expression databases
ArrayExpress	Q9ZSZ8.
Genevestigator	Q9ZSZ8.
GermOnline	AT3G54170. Arabidopsis thaliana.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

FIP37_ARATH

Accession

Primary (citable) accession number: Q9ZSZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)