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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

PP2A

Organism
Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Manganese 1By similarity
Metal bindingi56 – 561Manganese 1By similarity
Metal bindingi82 – 821Manganese 1By similarity
Metal bindingi82 – 821Manganese 2By similarity
Metal bindingi114 – 1141Manganese 2By similarity
Active sitei115 – 1151Proton donorBy similarity
Metal bindingi164 – 1641Manganese 2By similarity
Metal bindingi238 – 2381Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A
OrganismiHevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Taxonomic identifieri3981 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeCrotonoideaeMicrandreaeHevea

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Serine/threonine-protein phosphatase PP2A catalytic subunitPRO_0000058859Add
BLAST

Proteomic databases

PRIDEiQ9ZSE4.

Expressioni

Tissue specificityi

Expressed at the same level in latex as in leaves.

Structurei

3D structure databases

ProteinModelPortaliQ9ZSE4.
SMRiQ9ZSE4. Positions 6-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZSE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSHGDLDRQ IEHLMECKPL PEARGQTLCD QARAILVEEW NVQPVKCPVT
60 70 80 90 100
VCGDIHGQFY DLIELFRIGG NAPDTNYLFM GDYVDRGYYS VETVTLLVAL
110 120 130 140 150
KVRYRDRITI LRGNHESRQI TQVYGFYDEC LRKYGNANVW KYFTDLFDYL
160 170 180 190 200
PLTALIESQI FCLHGGLSPS LDTLDNIRAL DRIQEVPHEG PMCDLLWSDP
210 220 230 240 250
DDRCGWGISP RGAGYTFGQD IAAQFNHTNG LTLISRAHQL VMEGYNWCQE
260 270 280 290 300
KNVVTVFSAP NYCYRCGIMA AILEIGENMA QNFLQFDPAP RQIEPDTTRK

TPDYFL
Length:306
Mass (Da):34,969
Last modified:May 1, 1999 - v1
Checksum:iEFBE7F9DF4EB4A61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107464 mRNA. Translation: AAD09953.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107464 mRNA. Translation: AAD09953.1.

3D structure databases

ProteinModelPortaliQ9ZSE4.
SMRiQ9ZSE4. Positions 6-306.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9ZSE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of a cDNA encoding a type 2A serine/threonine protein phosphatase (PP2A) from Hevea brasiliensis."
    Shin D.H., Han K.-H.
    Plant Gene Register PGR99-011
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPP2A_HEVBR
AccessioniPrimary (citable) accession number: Q9ZSE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.