Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ZSE4

- PP2A_HEVBR

UniProt

Q9ZSE4 - PP2A_HEVBR

Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

PP2A

Organism
Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Manganese 1By similarity
    Metal bindingi56 – 561Manganese 1By similarity
    Metal bindingi82 – 821Manganese 1By similarity
    Metal bindingi82 – 821Manganese 2By similarity
    Metal bindingi114 – 1141Manganese 2By similarity
    Active sitei115 – 1151Proton donorBy similarity
    Metal bindingi164 – 1641Manganese 2By similarity
    Metal bindingi238 – 2381Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
    Gene namesi
    Name:PP2A
    OrganismiHevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
    Taxonomic identifieri3981 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeCrotonoideaeMicrandreaeHevea

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Serine/threonine-protein phosphatase PP2A catalytic subunitPRO_0000058859Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZSE4.

    Expressioni

    Tissue specificityi

    Expressed at the same level in latex as in leaves.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZSE4.
    SMRiQ9ZSE4. Positions 6-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZSE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSHGDLDRQ IEHLMECKPL PEARGQTLCD QARAILVEEW NVQPVKCPVT    50
    VCGDIHGQFY DLIELFRIGG NAPDTNYLFM GDYVDRGYYS VETVTLLVAL 100
    KVRYRDRITI LRGNHESRQI TQVYGFYDEC LRKYGNANVW KYFTDLFDYL 150
    PLTALIESQI FCLHGGLSPS LDTLDNIRAL DRIQEVPHEG PMCDLLWSDP 200
    DDRCGWGISP RGAGYTFGQD IAAQFNHTNG LTLISRAHQL VMEGYNWCQE 250
    KNVVTVFSAP NYCYRCGIMA AILEIGENMA QNFLQFDPAP RQIEPDTTRK 300
    TPDYFL 306
    Length:306
    Mass (Da):34,969
    Last modified:May 1, 1999 - v1
    Checksum:iEFBE7F9DF4EB4A61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107464 mRNA. Translation: AAD09953.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107464 mRNA. Translation: AAD09953.1 .

    3D structure databases

    ProteinModelPortali Q9ZSE4.
    SMRi Q9ZSE4. Positions 6-306.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9ZSE4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA encoding a type 2A serine/threonine protein phosphatase (PP2A) from Hevea brasiliensis."
      Shin D.H., Han K.-H.
      Plant Gene Register PGR99-011
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPP2A_HEVBR
    AccessioniPrimary (citable) accession number: Q9ZSE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3