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Protein

Syntaxin-121

Gene

SYP121

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the secretory pathway.By similarity

GO - Molecular functioni

  • protein membrane anchor Source: TAIR
  • SNAP receptor activity Source: InterPro
  • SNARE binding Source: GO_Central

GO - Biological processi

  • defense response Source: TAIR
  • defense response to fungus Source: TAIR
  • exocytosis Source: GO_Central
  • maintenance of protein location in plasma membrane Source: TAIR
  • negative regulation of defense response Source: TAIR
  • protein targeting to membrane Source: TAIR
  • regulation of stomatal movement Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to fungus Source: TAIR
  • transpiration Source: TAIR
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central
  • vesicle-mediated transport Source: TAIR

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-121
Short name:
AtSYP121
Alternative name(s):
Syntaxin-related protein At-Syr1
Gene namesi
Name:SYP121
Synonyms:SYR1
Ordered Locus Names:At3g11820
ORF Names:F26K24.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G11820.
TAIRilocus:2081476. AT3G11820.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 285CytoplasmicSequence analysisAdd BLAST285
Transmembranei286 – 306Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini307 – 346VesicularSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102461 – 346Syntaxin-121Add BLAST346
Isoform 2 (identifier: Q9ZSD4-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Isoform 2 (identifier: Q9ZSD4-2)
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9ZSD4.
PRIDEiQ9ZSD4.

PTM databases

iPTMnetiQ9ZSD4.
SwissPalmiQ9ZSD4.

Expressioni

Inductioni

Ninefold induction within 30-min exposure to abscisic acid and after 48 hours drought stress.

Gene expression databases

ExpressionAtlasiQ9ZSD4. baseline and differential.
GenevisibleiQ9ZSD4. AT.

Interactioni

Subunit structurei

Part of the t-SNARE complex. Binds to SNAP33.

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAP33Q9S7P94EBI-4476863,EBI-603017

GO - Molecular functioni

  • protein membrane anchor Source: TAIR
  • SNAP receptor activity Source: InterPro
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi5689. 69 interactors.
DIPiDIP-59829N.
IntActiQ9ZSD4. 60 interactors.
STRINGi3702.AT3G11820.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZSD4.
SMRiQ9ZSD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 276t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 76Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 298Poly-Ile10
Compositional biasi314 – 327Gly-richAdd BLAST14

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
HOGENOMiHOG000238904.
InParanoidiQ9ZSD4.
KOiK08486.
OMAiINLWQKN.
OrthoDBiEOG09360O8W.
PhylomeDBiQ9ZSD4.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PfamiView protein in Pfam
PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
SMARTiView protein in SMART
SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q9ZSD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDLFSSSFS RFRSGEPSPR RDVAGGGDGV QMANPAGSTG GVNLDKFFED
60 70 80 90 100
VESVKEELKE LDRLNETLSS CHEQSKTLHN AKAVKDLRSK MDGDVGVALK
110 120 130 140 150
KAKMIKVKLE ALDRANAANR SLPGCGPGSS SDRTRTSVLN GLRKKLMDSM
160 170 180 190 200
DSFNRLRELI SSEYRETVQR RYFTVTGENP DERTLDRLIS TGESERFLQK
210 220 230 240 250
AIQEQGRGRV LDTINEIQER HDAVKDIEKN LRELHQVFLD MAVLVEHQGA
260 270 280 290 300
QLDDIESHVG RASSFIRGGT DQLQTARVYQ KNTRKWTCIA IIILIIIITV
310 320 330 340
VVLAVLKPWN NSSGGGGGGG GGGTTGGSQP NSGTPPNPPQ ARRLLR
Length:346
Mass (Da):37,957
Last modified:May 1, 1999 - v1
Checksum:i8A6E2390761A8446
GO
Isoform 2 (identifier: Q9ZSD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:315
Mass (Da):34,658
Checksum:iAAEE59276AFDDB53
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0579471 – 31Missing in isoform 2. CuratedAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112864 mRNA. Translation: AAD11809.1.
AC016795 Genomic DNA. Translation: AAF23198.1.
CP002686 Genomic DNA. Translation: AEE75102.1.
CP002686 Genomic DNA. Translation: AEE75103.1.
AY093151 mRNA. Translation: AAM13150.1.
BT003393 mRNA. Translation: AAO30056.1.
AY087842 mRNA. Translation: AAM65395.1.
RefSeqiNP_187788.1. NM_112015.3. [Q9ZSD4-1]
NP_974288.1. NM_202559.3. [Q9ZSD4-2]
UniGeneiAt.11000.
At.70633.

Genome annotation databases

EnsemblPlantsiAT3G11820.1; AT3G11820.1; AT3G11820. [Q9ZSD4-1]
AT3G11820.2; AT3G11820.2; AT3G11820. [Q9ZSD4-2]
GeneIDi820355.
GrameneiAT3G11820.1; AT3G11820.1; AT3G11820.
AT3G11820.2; AT3G11820.2; AT3G11820.
KEGGiath:AT3G11820.

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiSY121_ARATH
AccessioniPrimary (citable) accession number: Q9ZSD4
Secondary accession number(s): F4J7G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families