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Q9ZSB5

- UBP10_ARATH

UniProt

Q9ZSB5 - UBP10_ARATH

Protein

Ubiquitin carboxyl-terminal hydrolase 10

Gene

UBP10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei313 – 3131NucleophilePROSITE-ProRule annotation
    Active sitei853 – 8531Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. protein deubiquitination Source: InterPro
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciARA:AT4G10570-MONOMER.

    Protein family/group databases

    MEROPSiC19.A02.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 10 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 10
    Short name:
    AtUBP10
    Ubiquitin thioesterase 10
    Ubiquitin-specific-processing protease 10
    Gene namesi
    Name:UBP10
    Ordered Locus Names:At4g10570
    ORF Names:F3H7.5, T4F9.30
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G10570.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 923923Ubiquitin carboxyl-terminal hydrolase 10PRO_0000313037Add
    BLAST

    Proteomic databases

    PaxDbiQ9ZSB5.
    PRIDEiQ9ZSB5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ZSB5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZSB5.
    SMRiQ9ZSB5. Positions 29-227, 302-483, 747-894.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 134116DUSPPROSITE-ProRule annotationAdd
    BLAST
    Domaini304 – 895592USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi232 – 2376Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 DUSP domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    HOGENOMiHOG000264375.
    InParanoidiQ9ZSB5.
    KOiK11835.
    OMAiGRIKRTA.
    PhylomeDBiQ9ZSB5.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028134. USP.
    [Graphical view]
    PANTHERiPTHR24006:SF360. PTHR24006:SF360. 1 hit.
    PfamiPF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    PROSITEiPS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZSB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIPNSDFML ENGVCDLPFT PEEEKRIVSE LTSESEDNLK QGNLYFVISK    50
    RWYTSWQEYV ENSANECSTG ESSEAPRPGP IDNHDIIESD SDINDPQLRR 100
    LLVEGEDYVL VPKQVWKRLV EWYSGGPPIE RKLICQGFYT RSYSVEVYPL 150
    CLMLTDGRDE SRTVIRLGKQ ASIRELYEKV CAMTGVPQEK AHIWDYFDKR 200
    KNGLLDPLSY KSLEESSLHM DQDILVEVDG LSSSSQSAMS STGNELALVP 250
    LEPSRSIVTI AGGPTLSNGH STTSNFSLFP RITSEDDGRD SLSILGKGEK 300
    GGLAGLSNLG NTCFMNSALQ CLAHTPPIVE YFLQDYSDDI NRDNPLGMCG 350
    ELAIAFGDLL KKLWSSGRNA VAPRAFKTKL ARFAPQFSGY NQHDSQELLA 400
    FLLDGLHEDL NKVKRKPYIE LKDSDSRPDD EVAEELWNYH KARNDSVIVD 450
    VCQGQYKSTL VCPVCGKISI TFDPFMYLSV PLPSTLTRSM TITVFYCDGS 500
    RLPMPYTVIV PKQGSIRDLI TALGTACCLA EDESLLLAEV YDHKIFRYFE 550
    IPLDSLSAIK DDEHIVAYRL NQIPKGSRKA KLEILHGGQE RAVLDSVRGS 600
    DVKLFGTPFV TYVNTEPLSG TDIDAVISGF LSPLHKVHAP SKIHNGSDNG 650
    HLADATVDQA SGILSSPDTE IDNASDRELS FRIFLTDERG LNIKPLQSES 700
    SISPGTVTRV LVEWNEGEHE RYDSSYLSDL PEVHKTSFSA KKTRQESISL 750
    FSCLEAFLAE EPLGPDDMWF CPSCKEHRQA NKKLDLWKLP DILVFHLKRF 800
    TYSRYLKNKI DTFVNFPVHD LDLSKYVKNK NGQSYLYELY AVSNHYGGLG 850
    GGHYTAYAKL IDDNKWYHFD DSHVSSVNES EIRNSAAYVL FYRRVRSETE 900
    TQTAEMSTDM DYSCLNSHND KAS 923
    Length:923
    Mass (Da):103,699
    Last modified:January 15, 2008 - v2
    Checksum:iBF90A1E6CFB474AF
    GO

    Sequence cautioni

    The sequence BT004132 differs from that shown. Reason: Frameshift at position 921.
    The sequence AAD03433.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB40023.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB78180.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118222 Genomic DNA. Translation: AAD03433.1. Sequence problems.
    AL049523 Genomic DNA. Translation: CAB40023.1. Sequence problems.
    AL161517 Genomic DNA. Translation: CAB78180.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE82900.1.
    BT004132 mRNA. No translation available.
    PIRiT04192.
    RefSeqiNP_192795.3. NM_117125.3.
    UniGeneiAt.48842.

    Genome annotation databases

    EnsemblPlantsiAT4G10570.1; AT4G10570.1; AT4G10570.
    GeneIDi826649.
    KEGGiath:AT4G10570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118222 Genomic DNA. Translation: AAD03433.1 . Sequence problems.
    AL049523 Genomic DNA. Translation: CAB40023.1 . Sequence problems.
    AL161517 Genomic DNA. Translation: CAB78180.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE82900.1 .
    BT004132 mRNA. No translation available.
    PIRi T04192.
    RefSeqi NP_192795.3. NM_117125.3.
    UniGenei At.48842.

    3D structure databases

    ProteinModelPortali Q9ZSB5.
    SMRi Q9ZSB5. Positions 29-227, 302-483, 747-894.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A02.

    Proteomic databases

    PaxDbi Q9ZSB5.
    PRIDEi Q9ZSB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G10570.1 ; AT4G10570.1 ; AT4G10570 .
    GeneIDi 826649.
    KEGGi ath:AT4G10570.

    Organism-specific databases

    TAIRi AT4G10570.

    Phylogenomic databases

    eggNOGi COG5560.
    HOGENOMi HOG000264375.
    InParanoidi Q9ZSB5.
    KOi K11835.
    OMAi GRIKRTA.
    PhylomeDBi Q9ZSB5.

    Enzyme and pathway databases

    BioCyci ARA:AT4G10570-MONOMER.

    Gene expression databases

    Genevestigatori Q9ZSB5.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028134. USP.
    [Graphical view ]
    PANTHERi PTHR24006:SF360. PTHR24006:SF360. 1 hit.
    Pfami PF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    PROSITEi PS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
      Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
      Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

    Entry informationi

    Entry nameiUBP10_ARATH
    AccessioniPrimary (citable) accession number: Q9ZSB5
    Secondary accession number(s): Q9T0B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3