ID   CHS2_DAUCA              Reviewed;         397 AA.
AC   Q9ZS40;
DT   08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   22-SEP-2009, entry version 55.
DE   RecName: Full=Chalcone synthase 2;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase 2;
DE   AltName: Full=DcCHS2;
GN   Name=CHS2;
OS   Daucus carota (Carrot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae;
OC   Daucinae; Daucus.
OX   NCBI_TaxID=4039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=20330993; PubMed=10872233; DOI=10.1007/s004250050708;
RA   Hirner A.A., Seitz H.U.;
RT   "Isoforms of chalcone synthase in Daucus carota L. and their
RT   differential expression in organs from the European wild carrot and in
RT   ultraviolet-A-irradiated cell cultures.";
RL   Planta 210:993-998(2000).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA +
CC       naringenin chalcone + 3 CO(2).
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the chalcone/stilbene synthases family.
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DR   EMBL; AJ006780; CAA07245.1; -; mRNA.
DR   HSSP; P30074; 1CGZ.
DR   SMR; Q9ZS40; 8-391.
DR   BRENDA; 2.3.1.74; 1081.
DR   GO; GO:0008415; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR012328; Chalcone/stilbene_synth_C.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR001099; Chalcone/stilbene_synthase_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   ProDom; PD000453; N-C_synthase; 1.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN         1    397       Chalcone synthase 2.
FT                                /FTId=PRO_0000215971.
FT   ACT_SITE    168    168       By similarity.
SQ   SEQUENCE   397 AA;  43559 MW;  9386F44B9132EDEE CRC64;
     MANHNAEIEE IRKRQRAQGP ANILAIGTAT PSNCVYQADY PDYYFRITNS EHMSDLKLKF
     KRMCEKSMIR KRYMHITEEY LKENPNVCAY EAPSLDARQD LVVVEVPRLG KEAAAKAIKE
     WGHPKSKITH LIFCTTSGVD MPGADYQLTK LLGLRPSVKR FMMYQQGCFA GGTVLRLAKD
     LAENNTGARV LVVCSEITAV TFRGPSDSHL DSLVGQALFG DGAAAVIVGS DPDLSVERPL
     FQLISAAQTI LPDSDGAIDG HLREVGLTFH LLKDVPGLIS KNIEKSLKEA FGPIGISDWN
     SLFWIAHPGG PAILDQVELK LGLKEEKMRA TRQVLSDYGN MSSACVLFIL DEMRKKSIEE
     GKATTGDGLD WGVLFGFGPG LTVETVVLHS VPATITH
//