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Q9ZRW8

- GSTUJ_ARATH

UniProt

Q9ZRW8 - GSTUJ_ARATH

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Protein
Glutathione S-transferase U19
Gene
GSTU19, GST8, At1g78380, F3F9.11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the glutathionylation of 12-oxophytodienoate (OPDA). In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC), and glutathione peroxidase activity toward cumene hydroperoxide.3 Publications

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione binding Source: TAIR
  2. glutathione transferase activity Source: TAIR
  3. peroxidase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to water deprivation Source: TAIR
  2. response to cadmium ion Source: TAIR
  3. response to oxidative stress Source: TAIR
  4. response to toxic substance Source: UniProtKB-KW
  5. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase, Transferase

Keywords - Biological processi

Detoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT1G78380-MONOMER.
MetaCyc:AT1G78380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U19 (EC:2.5.1.18)
Short name:
AtGSTU19
Alternative name(s):
GST class-tau member 19
Glutathione S-transferase 8
Gene namesi
Name:GSTU19
Synonyms:GST8
Ordered Locus Names:At1g78380
ORF Names:F3F9.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G78380.

Subcellular locationi

Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. chloroplast stroma Source: TAIR
  3. cytoplasm Source: TAIR
  4. cytosol Source: TAIR
  5. plasma membrane Source: TAIR
  6. vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 219218Glutathione S-transferase U19
PRO_0000413565Add
BLAST

Proteomic databases

PRIDEiQ9ZRW8.

Expressioni

Inductioni

By dehydration stress, salicylic acid, ethylene, methyl jasmonate, auxin, H2O2, copper, benoxacor, isothiocyanates and the pathogen Hyaloperonospora parasitica.6 Publications

Gene expression databases

ArrayExpressiQ9ZRW8.
GenevestigatoriQ9ZRW8.

Interactioni

Protein-protein interaction databases

BioGridi29393. 6 interactions.
IntActiQ9ZRW8. 5 interactions.
STRINGi3702.AT1G78380.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZRW8.
SMRiQ9ZRW8. Positions 4-216.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8280GST N-terminal
Add
BLAST
Domaini88 – 208121GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 142Glutathione binding By similarity
Regioni39 – 402Glutathione binding By similarity
Regioni53 – 542Glutathione binding By similarity
Regioni66 – 672Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.

Phylogenomic databases

HOGENOMiHOG000125749.
InParanoidiQ9ZRW8.
KOiK00799.
OMAiDFWANGF.
PhylomeDBiQ9ZRW8.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZRW8-1 [UniParc]FASTAAdd to Basket

« Hide

MANEVILLDF WPSMFGMRTR IALREKGVEF EYREEDLRNK SPLLLQMNPI    50
HKKIPVLIHN GKPVNESIIQ VQYIDEVWSH KNPILPSDPY LRAQARFWAD 100
FIDKKLYDAQ RKVWATKGEE QEAGKKDFIE ILKTLESELG DKPYFSGDDF 150
GYVDIALIGF YTWFPAYEKF ANFSIESEVP KLIAWVKKCL QRESVAKSLP 200
DPEKVTEFVS ELRKKFVPE 219
Length:219
Mass (Da):25,651
Last modified:May 1, 1999 - v1
Checksum:iE79AABD8C14C6F15
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161G → R in AAM64593. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012571 mRNA. Translation: CAA10060.1.
AC013430 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE36099.1.
AF385691 mRNA. Translation: AAK60284.1.
AY078012 mRNA. Translation: AAL77713.1.
AY087032 mRNA. Translation: AAM64593.1.
PIRiT51607.
RefSeqiNP_565178.1. NM_106485.3.
UniGeneiAt.25493.
At.67704.

Genome annotation databases

EnsemblPlantsiAT1G78380.1; AT1G78380.1; AT1G78380.
GeneIDi844174.
KEGGiath:AT1G78380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012571 mRNA. Translation: CAA10060.1 .
AC013430 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE36099.1 .
AF385691 mRNA. Translation: AAK60284.1 .
AY078012 mRNA. Translation: AAL77713.1 .
AY087032 mRNA. Translation: AAM64593.1 .
PIRi T51607.
RefSeqi NP_565178.1. NM_106485.3.
UniGenei At.25493.
At.67704.

3D structure databases

ProteinModelPortali Q9ZRW8.
SMRi Q9ZRW8. Positions 4-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 29393. 6 interactions.
IntActi Q9ZRW8. 5 interactions.
STRINGi 3702.AT1G78380.1-P.

Proteomic databases

PRIDEi Q9ZRW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G78380.1 ; AT1G78380.1 ; AT1G78380 .
GeneIDi 844174.
KEGGi ath:AT1G78380.

Organism-specific databases

TAIRi AT1G78380.

Phylogenomic databases

HOGENOMi HOG000125749.
InParanoidi Q9ZRW8.
KOi K00799.
OMAi DFWANGF.
PhylomeDBi Q9ZRW8.

Enzyme and pathway databases

BioCyci ARA:AT1G78380-MONOMER.
MetaCyc:AT1G78380-MONOMER.

Gene expression databases

ArrayExpressi Q9ZRW8.
Genevestigatori Q9ZRW8.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Drought regulation of GST8, encoding the Arabidopsis homologue of ParC/Nt107 glutathione transferase/peroxidase."
    Bianchi M.W., Roux C., Vartanian N.
    Physiol. Plantarum 116:96-105(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  7. "Induction of glutathione S-transferases in Arabidopsis by herbicide safeners."
    DeRidder B.P., Dixon D.P., Beussman D.J., Edwards R., Goldsbrough P.B.
    Plant Physiol. 130:1497-1505(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Proteomic analysis of Arabidopsis glutathione S-transferases from benoxacor- and copper-treated seedlings."
    Smith A.P., DeRidder B.P., Guo W.J., Seeley E.H., Regnier F.E., Goldsbrough P.B.
    J. Biol. Chem. 279:26098-26104(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "Organ-specific expression of glutathione S-transferases and the efficacy of herbicide safeners in Arabidopsis."
    DeRidder B.P., Goldsbrough P.B.
    Plant Physiol. 140:167-175(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "Selective binding of glutathione conjugates of fatty acid derivatives by plant glutathione transferases."
    Dixon D.P., Edwards R.
    J. Biol. Chem. 284:21249-21256(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
    Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
    J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "Exogenously applied isothiocyanates enhance glutathione S-transferase expression in Arabidopsis but act as herbicides at higher concentrations."
    Hara M., Yatsuzuka Y., Tabata K., Kuboi T.
    J. Plant Physiol. 167:643-649(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiGSTUJ_ARATH
AccessioniPrimary (citable) accession number: Q9ZRW8
Secondary accession number(s): Q8LBS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi