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Q9ZRT5

- GSTT1_ARATH

UniProt

Q9ZRT5 - GSTT1_ARATH

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Protein

Glutathione S-transferase T1

Gene

GSTT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrobenzyl chloride (pNBC), and glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide. May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
  2. peroxidase activity Source: UniProtKB-KW

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
  2. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase, Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT5G41210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase T1 (EC:2.5.1.18)
Short name:
AtGSTT1
Alternative name(s):
GST class-theta member 1
Glutathione S-transferase 10
Gene namesi
Name:GSTT1
Synonyms:GST10
Ordered Locus Names:At5g41210
ORF Names:MEE6.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G41210.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: UniProtKB-KW
  3. peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Glutathione S-transferase T1PRO_0000413574Add
BLAST

Proteomic databases

PaxDbiQ9ZRT5.
PRIDEiQ9ZRT5.

Expressioni

Gene expression databases

GenevestigatoriQ9ZRT5.

Interactioni

Protein-protein interaction databases

BioGridi19374. 2 interactions.
IntActiQ9ZRT5. 1 interaction.
STRINGi3702.AT5G41210.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZRT5.
SMRiQ9ZRT5. Positions 2-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8382GST N-terminalAdd
BLAST
Domaini90 – 233144GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 132Glutathione bindingBy similarity
Regioni41 – 422Glutathione bindingBy similarity
Regioni54 – 552Glutathione bindingBy similarity
Regioni67 – 682Glutathione bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi243 – 2453Microbody targeting signalSequence Analysis

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125747.
InParanoidiQ9ZRT5.
KOiK00799.
OMAiHTNLRRG.
PhylomeDBiQ9ZRT5.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZRT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKLKVYADR MSQPSRAVII FCKVNGIQFD EVLISLAKRQ QLSPEFKDIN
60 70 80 90 100
PLGKVPAIVD GRLKLFESHA ILIYLSSAFP SVADHWYPND LSKRAKIHSV
110 120 130 140 150
LDWHHTNLRR GAAGYVLNSV LGPALGLPLN PKAAAEAEQL LTKSLSTLET
160 170 180 190 200
FWLKGNAKFL LGSNQPSIAD LSLVCELMQL QVLDDKDRLR LLSTHKKVEQ
210 220 230 240
WIENTKKATM PHFDETHEIL FKVKEGFQKR REMGTLSKPG LQSKI
Length:245
Mass (Da):27,653
Last modified:May 1, 1999 - v1
Checksum:i6F16FE1399E793B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131580 mRNA. Translation: CAA10457.1.
AB010072 Genomic DNA. Translation: BAB09723.1.
CP002688 Genomic DNA. Translation: AED94654.1.
AY054659 mRNA. Translation: AAK96850.1.
AY072466 mRNA. Translation: AAL66881.1.
PIRiT51594.
RefSeqiNP_198937.1. NM_123486.3.
UniGeneiAt.24905.

Genome annotation databases

EnsemblPlantsiAT5G41210.1; AT5G41210.1; AT5G41210.
GeneIDi834123.
KEGGiath:AT5G41210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131580 mRNA. Translation: CAA10457.1 .
AB010072 Genomic DNA. Translation: BAB09723.1 .
CP002688 Genomic DNA. Translation: AED94654.1 .
AY054659 mRNA. Translation: AAK96850.1 .
AY072466 mRNA. Translation: AAL66881.1 .
PIRi T51594.
RefSeqi NP_198937.1. NM_123486.3.
UniGenei At.24905.

3D structure databases

ProteinModelPortali Q9ZRT5.
SMRi Q9ZRT5. Positions 2-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 19374. 2 interactions.
IntActi Q9ZRT5. 1 interaction.
STRINGi 3702.AT5G41210.1-P.

Proteomic databases

PaxDbi Q9ZRT5.
PRIDEi Q9ZRT5.

Protocols and materials databases

DNASUi 834123.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G41210.1 ; AT5G41210.1 ; AT5G41210 .
GeneIDi 834123.
KEGGi ath:AT5G41210.

Organism-specific databases

TAIRi AT5G41210.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125747.
InParanoidi Q9ZRT5.
KOi K00799.
OMAi HTNLRRG.
PhylomeDBi Q9ZRT5.

Enzyme and pathway databases

BioCyci ARA:AT5G41210-MONOMER.

Gene expression databases

Genevestigatori Q9ZRT5.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of AtGST 10, members of a novel type of plant glutathione transferases."
    Dixon D.P., Cole D.J., Edwards R.
    Plant Gene Register PGR99-053
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
    Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  6. "Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
    Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
    J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGSTT1_ARATH
AccessioniPrimary (citable) accession number: Q9ZRT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3