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Q9ZRT5

- GSTT1_ARATH

UniProt

Q9ZRT5 - GSTT1_ARATH

Protein

Glutathione S-transferase T1

Gene

GSTT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrobenzyl chloride (pNBC), and glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide. May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC
    2. peroxidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW
    2. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase, Transferase

    Keywords - Biological processi

    Detoxification

    Enzyme and pathway databases

    BioCyciARA:AT5G41210-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase T1 (EC:2.5.1.18)
    Short name:
    AtGSTT1
    Alternative name(s):
    GST class-theta member 1
    Glutathione S-transferase 10
    Gene namesi
    Name:GSTT1
    Synonyms:GST10
    Ordered Locus Names:At5g41210
    ORF Names:MEE6.28
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G41210.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. nucleus Source: UniProtKB-SubCell
    3. peroxisome Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Glutathione S-transferase T1PRO_0000413574Add
    BLAST

    Proteomic databases

    PaxDbiQ9ZRT5.
    PRIDEiQ9ZRT5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ZRT5.

    Interactioni

    Protein-protein interaction databases

    BioGridi19374. 2 interactions.
    IntActiQ9ZRT5. 1 interaction.
    STRINGi3702.AT5G41210.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZRT5.
    SMRiQ9ZRT5. Positions 2-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8382GST N-terminalAdd
    BLAST
    Domaini90 – 233144GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni12 – 132Glutathione bindingBy similarity
    Regioni41 – 422Glutathione bindingBy similarity
    Regioni54 – 552Glutathione bindingBy similarity
    Regioni67 – 682Glutathione bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi243 – 2453Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125747.
    InParanoidiQ9ZRT5.
    KOiK00799.
    OMAiHTNLRRG.
    PhylomeDBiQ9ZRT5.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZRT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKLKVYADR MSQPSRAVII FCKVNGIQFD EVLISLAKRQ QLSPEFKDIN    50
    PLGKVPAIVD GRLKLFESHA ILIYLSSAFP SVADHWYPND LSKRAKIHSV 100
    LDWHHTNLRR GAAGYVLNSV LGPALGLPLN PKAAAEAEQL LTKSLSTLET 150
    FWLKGNAKFL LGSNQPSIAD LSLVCELMQL QVLDDKDRLR LLSTHKKVEQ 200
    WIENTKKATM PHFDETHEIL FKVKEGFQKR REMGTLSKPG LQSKI 245
    Length:245
    Mass (Da):27,653
    Last modified:May 1, 1999 - v1
    Checksum:i6F16FE1399E793B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ131580 mRNA. Translation: CAA10457.1.
    AB010072 Genomic DNA. Translation: BAB09723.1.
    CP002688 Genomic DNA. Translation: AED94654.1.
    AY054659 mRNA. Translation: AAK96850.1.
    AY072466 mRNA. Translation: AAL66881.1.
    PIRiT51594.
    RefSeqiNP_198937.1. NM_123486.3.
    UniGeneiAt.24905.

    Genome annotation databases

    EnsemblPlantsiAT5G41210.1; AT5G41210.1; AT5G41210.
    GeneIDi834123.
    KEGGiath:AT5G41210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ131580 mRNA. Translation: CAA10457.1 .
    AB010072 Genomic DNA. Translation: BAB09723.1 .
    CP002688 Genomic DNA. Translation: AED94654.1 .
    AY054659 mRNA. Translation: AAK96850.1 .
    AY072466 mRNA. Translation: AAL66881.1 .
    PIRi T51594.
    RefSeqi NP_198937.1. NM_123486.3.
    UniGenei At.24905.

    3D structure databases

    ProteinModelPortali Q9ZRT5.
    SMRi Q9ZRT5. Positions 2-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 19374. 2 interactions.
    IntActi Q9ZRT5. 1 interaction.
    STRINGi 3702.AT5G41210.1-P.

    Proteomic databases

    PaxDbi Q9ZRT5.
    PRIDEi Q9ZRT5.

    Protocols and materials databases

    DNASUi 834123.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G41210.1 ; AT5G41210.1 ; AT5G41210 .
    GeneIDi 834123.
    KEGGi ath:AT5G41210.

    Organism-specific databases

    TAIRi AT5G41210.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125747.
    InParanoidi Q9ZRT5.
    KOi K00799.
    OMAi HTNLRRG.
    PhylomeDBi Q9ZRT5.

    Enzyme and pathway databases

    BioCyci ARA:AT5G41210-MONOMER.

    Gene expression databases

    Genevestigatori Q9ZRT5.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of AtGST 10, members of a novel type of plant glutathione transferases."
      Dixon D.P., Cole D.J., Edwards R.
      Plant Gene Register PGR99-053
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
      Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
      DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GENE FAMILY, NOMENCLATURE.
      Strain: cv. Columbia.
    6. "Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
      Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
      J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiGSTT1_ARATH
    AccessioniPrimary (citable) accession number: Q9ZRT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3