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Protein

Glutathione S-transferase T1

Gene

GSTT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrobenzyl chloride (pNBC), and glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide. May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionOxidoreductase, Peroxidase, Transferase
Biological processDetoxification

Enzyme and pathway databases

BioCyciARA:AT5G41210-MONOMER
ReactomeiR-ATH-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase T1 (EC:2.5.1.18)
Short name:
AtGSTT1
Alternative name(s):
GST class-theta member 1
Glutathione S-transferase 10
Gene namesi
Name:GSTT1
Synonyms:GST10
Ordered Locus Names:At5g41210
ORF Names:MEE6.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G41210
TAIRilocus:2163096 AT5G41210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135741 – 245Glutathione S-transferase T1Add BLAST245

Proteomic databases

PaxDbiQ9ZRT5
PRIDEiQ9ZRT5

PTM databases

iPTMnetiQ9ZRT5

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZRT5 baseline and differential
GenevisibleiQ9ZRT5 AT

Interactioni

Protein-protein interaction databases

BioGridi19374, 2 interactors
IntActiQ9ZRT5, 1 interactor
STRINGi3702.AT5G41210.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZRT5
SMRiQ9ZRT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 83GST N-terminalAdd BLAST82
Domaini90 – 233GST C-terminalAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 13Glutathione bindingBy similarity2
Regioni41 – 42Glutathione bindingBy similarity2
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi243 – 245Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
HOGENOMiHOG000125747
InParanoidiQ9ZRT5
KOiK00799
OMAiSCNPHYD
OrthoDBiEOG09360L2Z
PhylomeDBiQ9ZRT5

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZRT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKLKVYADR MSQPSRAVII FCKVNGIQFD EVLISLAKRQ QLSPEFKDIN
60 70 80 90 100
PLGKVPAIVD GRLKLFESHA ILIYLSSAFP SVADHWYPND LSKRAKIHSV
110 120 130 140 150
LDWHHTNLRR GAAGYVLNSV LGPALGLPLN PKAAAEAEQL LTKSLSTLET
160 170 180 190 200
FWLKGNAKFL LGSNQPSIAD LSLVCELMQL QVLDDKDRLR LLSTHKKVEQ
210 220 230 240
WIENTKKATM PHFDETHEIL FKVKEGFQKR REMGTLSKPG LQSKI
Length:245
Mass (Da):27,653
Last modified:May 1, 1999 - v1
Checksum:i6F16FE1399E793B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131580 mRNA Translation: CAA10457.1
AB010072 Genomic DNA Translation: BAB09723.1
CP002688 Genomic DNA Translation: AED94654.1
AY054659 mRNA Translation: AAK96850.1
AY072466 mRNA Translation: AAL66881.1
PIRiT51594
RefSeqiNP_198937.1, NM_123486.4
UniGeneiAt.24905

Genome annotation databases

EnsemblPlantsiAT5G41210.1; AT5G41210.1; AT5G41210
GeneIDi834123
GrameneiAT5G41210.1; AT5G41210.1; AT5G41210
KEGGiath:AT5G41210

Similar proteinsi

Entry informationi

Entry nameiGSTT1_ARATH
AccessioniPrimary (citable) accession number: Q9ZRT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health