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Protein

Glutathione S-transferase T1

Gene

GSTT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrobenzyl chloride (pNBC), and glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide. May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase, Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT5G41210-MONOMER.
ReactomeiR-ATH-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase T1 (EC:2.5.1.18)
Short name:
AtGSTT1
Alternative name(s):
GST class-theta member 1
Glutathione S-transferase 10
Gene namesi
Name:GSTT1
Synonyms:GST10
Ordered Locus Names:At5g41210
ORF Names:MEE6.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G41210.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • nucleus Source: UniProtKB-SubCell
  • peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135741 – 245Glutathione S-transferase T1Add BLAST245

Proteomic databases

PaxDbiQ9ZRT5.
PRIDEiQ9ZRT5.

PTM databases

iPTMnetiQ9ZRT5.

Expressioni

Gene expression databases

GenevisibleiQ9ZRT5. AT.

Interactioni

Protein-protein interaction databases

BioGridi19374. 2 interactors.
IntActiQ9ZRT5. 1 interactor.
STRINGi3702.AT5G41210.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZRT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 83GST N-terminalAdd BLAST82
Domaini90 – 233GST C-terminalAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 13Glutathione bindingBy similarity2
Regioni41 – 42Glutathione bindingBy similarity2
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi243 – 245Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000125747.
InParanoidiQ9ZRT5.
KOiK00799.
OMAiEVHELLF.
OrthoDBiEOG09360L2Z.
PhylomeDBiQ9ZRT5.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZRT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKLKVYADR MSQPSRAVII FCKVNGIQFD EVLISLAKRQ QLSPEFKDIN
60 70 80 90 100
PLGKVPAIVD GRLKLFESHA ILIYLSSAFP SVADHWYPND LSKRAKIHSV
110 120 130 140 150
LDWHHTNLRR GAAGYVLNSV LGPALGLPLN PKAAAEAEQL LTKSLSTLET
160 170 180 190 200
FWLKGNAKFL LGSNQPSIAD LSLVCELMQL QVLDDKDRLR LLSTHKKVEQ
210 220 230 240
WIENTKKATM PHFDETHEIL FKVKEGFQKR REMGTLSKPG LQSKI
Length:245
Mass (Da):27,653
Last modified:May 1, 1999 - v1
Checksum:i6F16FE1399E793B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131580 mRNA. Translation: CAA10457.1.
AB010072 Genomic DNA. Translation: BAB09723.1.
CP002688 Genomic DNA. Translation: AED94654.1.
AY054659 mRNA. Translation: AAK96850.1.
AY072466 mRNA. Translation: AAL66881.1.
PIRiT51594.
RefSeqiNP_198937.1. NM_123486.4.
UniGeneiAt.24905.

Genome annotation databases

EnsemblPlantsiAT5G41210.1; AT5G41210.1; AT5G41210.
GeneIDi834123.
GrameneiAT5G41210.1; AT5G41210.1; AT5G41210.
KEGGiath:AT5G41210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131580 mRNA. Translation: CAA10457.1.
AB010072 Genomic DNA. Translation: BAB09723.1.
CP002688 Genomic DNA. Translation: AED94654.1.
AY054659 mRNA. Translation: AAK96850.1.
AY072466 mRNA. Translation: AAL66881.1.
PIRiT51594.
RefSeqiNP_198937.1. NM_123486.4.
UniGeneiAt.24905.

3D structure databases

ProteinModelPortaliQ9ZRT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi19374. 2 interactors.
IntActiQ9ZRT5. 1 interactor.
STRINGi3702.AT5G41210.1.

PTM databases

iPTMnetiQ9ZRT5.

Proteomic databases

PaxDbiQ9ZRT5.
PRIDEiQ9ZRT5.

Protocols and materials databases

DNASUi834123.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G41210.1; AT5G41210.1; AT5G41210.
GeneIDi834123.
GrameneiAT5G41210.1; AT5G41210.1; AT5G41210.
KEGGiath:AT5G41210.

Organism-specific databases

TAIRiAT5G41210.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000125747.
InParanoidiQ9ZRT5.
KOiK00799.
OMAiEVHELLF.
OrthoDBiEOG09360L2Z.
PhylomeDBiQ9ZRT5.

Enzyme and pathway databases

BioCyciARA:AT5G41210-MONOMER.
ReactomeiR-ATH-156590. Glutathione conjugation.

Miscellaneous databases

PROiQ9ZRT5.

Gene expression databases

GenevisibleiQ9ZRT5. AT.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTT1_ARATH
AccessioniPrimary (citable) accession number: Q9ZRT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.